Relationship between exposure to air pollutants and development of systemic autoimmune rheumatic diseases: a nationwide population-based case–control study

Tang, Kuo‐Tung; Tsuang, Ben‐Jei; Ku, Kai Chen; Chen, Yi Hsing; Lin, Ching Heng; Chen, Der Yuan

doi:10.1136/annrheumdis-2019-215230

Cited by 13 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[6] A recent Taiwanese study discovered a positive association of NO 2 exposure with the development of SLE in adults. [29] A recent Brazilian study revealed that exposure to inhalable ne particles increases airway in ammation and systemic in ammation in cSLE patients. Although the exact mode of onset and disease progression of SLE remains elusive, the urban-rural difference in prevalence, clustering of disease prevalence around polluted regions, and low concordance rates among monozygotic twins with SLE (around 24%) indicate that environment has a strong impact on SLE.…”

Section: Discussionmentioning

confidence: 99%

Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus

Mai¹,

Shih²,

Lin³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background:Fine particulate matter (PM2.5) has been linked to induction of oxidative stress as well as pulmonary and systemic inflammation. We hypothesized that ambient PM2.5 variation would be associated with the occurrence of childhood-onset systemic lupus erythematosus (cSLE). Methods:We collected data from the Taiwan National health insurance research database and linked these data to the Taiwan Air Quality-Monitoring Database. Children <18 years old, identified from January 1, 2000 were followed up until the first diagnosis of cSLE was made or until December 31, 2012. The daily average PM2.5 was categorized into four quartile-based groups (Q1-Q4). We measured the incidence rate, hazard ratios (HRs), and 95% confidence intervals for cSLE stratified by the quartiles of PM2.5 concentration using Cox proportional hazards models adjusted for age, sex, monthly income, and urbanization. Results:A total of 394 children (0.16%) were newly diagnosed with cSLE during the observation period. The incidence rate for cSLE increased with PM2.5 levels, from 4.7 (Q1) to 21.9 (Q4) per 100,000 person-years. Compared with those exposed to the concentrations in the Q1 level, the adjusted HR from Q2 to Q4 for cSLE increased with PM2.5 exposure concentrations from 2.74 to 4.23. Conclusions:The present study provides evidence that long-term variations in PM2.5 levels are risk factors for the development of cSLE.

show abstract

Section: Discussionmentioning

confidence: 99%

Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus

Mai¹,

Shih²,

Lin³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The increased air pollutant concentration levels are positively correlated with the risk of SLE, NO2, SO2, CO, O3 and so on in the air are all considered to be potential risk factors for systemic inflammation in patients with SLE 14 . A nationwide population-based case–control study from Taiwan, China, support that the development of SLE was positively associated with NO 2 exposure, but negatively with CO exposure 15 . Fernandes et al explored the relationship between exposure to air pollutants and disease activities in 22 children with SLE (c-SLE), and found that exposure under PM10, NO 2 and CO for about 2 weeks was a risk factor for c-SLE activity (SLEDAI-2K > 8), and moving average of the PM10 increased to 13.4 μg/m 3 could increase the risk of SLEDAI-2K > 8 by 34% 16 .…”

Section: Introductionmentioning

confidence: 93%

The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study

Chen

Sun

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Environmental exposures interact with genetic factors has been thought to influence susceptibility of systemic lupus erythematosus (SLE) development. To evaluate the effects of environmental exposures on SLE, we conducted a population-based cohort study across Jiangsu Province, China, to examine the associations between the living environment including air and water pollution, population density, economic income level, etc. and the prevalence and mortality of hospitalized SLE (h-SLE) patients. A total of 2231 h-SLE patients were retrieved from a longitudinal SLE database collected by the Jiangsu Lupus Collaborative Group from 1999 to 2009. The results showed that: It existed regional differences on the prevalence of h-SLE patients in 96 administrative districts; The distribution of NO2 air concentration monitored by atmospheric remote sensors showed that three of the ultra-high-prevalence districts were located in the concentrated chemical industry emission area; h-SLE patient prevalence was positively correlated with the excessive levels of nitrogen in drinking water; The positive ratio of pericarditis and proteinuria was positively correlated with the prevalence of h-SLE patients and pollution not only induced a high h-SLE patient prevalence but also a higher mortality rate, which might be attributed to NOx pollution in the air and drinking water. In summary, our data suggested that NOx in air and drinking water may be one of the important predispositions of SLE, especially for patients with renal involvement.

show abstract

“…Costa 1 , D. Almeida 2,3 , M. Cerqueira 2 , J. Redondo Costa 2 , A. R. Ribeiro 2 , J. Neves 2 . 1 Hospital de Braga, Rheumatology, Braga, Portugal; 2 Hospital de Braga, Rheumatology, Braga, Portugal; 3 Unidade Local de Saúde do Alto Minho, Rheumatology, Ponte de Lima, Portugal Background: Although spondyloarthritis (SpA) is primarily a musculoskeletal condition, ocular involvement is an important clinical feature and contributes to the burden of disease. Acute anterior uveitis (AAU) is classically described as the most frequent extra-articular manifestation of SpA and in some cases the first clinical presentation.…”

Section: Fri0533mentioning

confidence: 99%

“…In a systematic literature review, the mean prevalence of AAU was 32.7% and a positive association between HLA-B27 positivity, axial SpA, male sex and uveitis has been reported (1). More recently, some cross-sectional studies have described lower odds of spondyloarthritis-related uveitis (SpA-U) in smokers than in patients who are ex smokers or never smokers (2). Predictors of SpA-U are poorly defined in literature and the influence of smoking status remains controversial.…”

Section: Fri0533mentioning

confidence: 99%

Fri0532 the Impact of Genetically Determined Serum Urate Levels on the Development of Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies

et al. 2020

View full text Add to dashboard Cite

Background:Conventional observational studies have identified serum urate (SU) as an independent risk factor for cardiovascular diseases (CVDs),1,2but the causal relationships remain unsettled, with potential confounding and reverse causality. When applied correctly, Mendelian randomization (MR) employing genetic variants as instrumental variables can eliminate these biases and allow for causal inference.Objectives:To conduct a systematic review and meta-analysis of English-language, peer-reviewed MR studies on the causal effects of SU on CVDs and assess validation of key MR assumptions.Methods:A research librarian conducted a search (inception to January 2020) of four databases (Medline, Embase, Cochrane Library, and Web of Science), which was supplemented by hand-search. Titles and abstracts were screened by two independent reviewers, who subsequently evaluated and extracted data from full-text of selected articles. Pooled meta-analysis was performed using random-effects weighting.Results:Of 1014 articles identified, 40 were selected for full-text review and 13 studies reporting on CVDs were included in the systematic review (Figure 1). The first was published in 2009 and five were published in 2018 or 2019 alone. The included studies were of varying quality in regards to satisfying the assumptions for MR design.Fig. 1: PRISMA flow diagram.Overall, there was little evidence for a causal association between SU and risk of CVDs (Table 1). Random-effects meta-analysis revealed that SU was not significantly associated with risk of CVDs (OR=1.04; 95% CI=0.99-1.09) (Figure 2). 11 of the 13 studies reported null estimates for the effects of genetically-determined SU levels on CVDs. Two studies with small numbers of cases (N=125 and 222) reported significant associations, but these pertained to highly-specific subgroups.Table 1.Summary of included studies. CAD: Coronary Artery Disease; CHD: Coronary Heart Disease; IHD: Ischaemic heart disease; MI: Myocardial Infarction; MR: Mendelian Randomization; PVD: Peripheral Vascular Disease; SNP: Single Nucleotide PolymorphismFirst author; yearNumber of SNPs analyzedOutcome(n cases)PowerMR criteria validated:1. relevance2. pleiotropy3. confoundingConclusionStark; 200910 separatelyCAD (1,473)30%-66%1, 3NullYang; 20108 combinedCHD (3,050)<80%1, 2, 3NullPalmer; 20131 (rs7442295)IHD (3,742)N/A1, 2*, 3NullKleber; 20158 combinedCAD (2,418)PVD (295)N/A1, 2, 3NullHan; 20152 separatelyCHD (1,146)80%1, 2*, 3NullTesta; 20151 (rs734553)CVD events (CVD death, stroke, MI) (222)N/A1, 2*Significant for CV eventsWhite; 201631 combinedCAD (65,877)83%1, 2, 3NullKeenan; 201614 combinedCHD (54,501)Stroke (14,779)>80%1, 2, 3NullLi; 201831 combinedIHD (9,467)MI (3,625)70%1, 2, 3NullLi; 201931 combinedCHD (60,801)MI (43,676)Stroke (10,307)N/A1, 2, 3NullMacias-Kauffer; 20192 separatelyCAD (704)N/A1, 2*, 3NullEfstathiadou; 201928 separatelyCHD (184,305)MI (54,162) Stroke (514,791)>80%1, 2, 3NullChiang; 20198 combinedCHD (125)Stroke (57)N/A1, 2, 3Significant for CHD* Risk of pleiotropy (assumption 2) is low when utilizing few well-established SNPsFig. 2: Pooled meta-analysis results.Conclusion:Evidence from this systematic review does not support a causal role for SU levels and CVDs. As such, interventions targeting SU levels alone are unlikely to lower the risk of CVDs.References:[1] Zhu Y, Pandya BJ, Choi HK. Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. Am J Med 2012;125:679-87 e1.[2] Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation 2007;116:894-900Disclosure of Interests:Jeewoong Choi: None declared, Natalie McCormick: None declared, Shelby Marozoff: None declared, Mary De Vera: None declared, Hyon Choi Grant/research support from: Ironwood, Horizon, Consultant of: Takeda, Selecta, Horizon, Kowa, Vaxart, Ironwood

show abstract

Relationship between exposure to air pollutants and development of systemic autoimmune rheumatic diseases: a nationwide population-based case–control study

Cited by 13 publications

References 6 publications

Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus

Associarions Between Fine Particulate Matter (PM2.5) and Childhood-Onset Systemic Lupus Erythematosus

The relationship of polluted air and drinking water sources with the prevalence of systemic lupus erythematosus: a provincial population-based study

Fri0532 the Impact of Genetically Determined Serum Urate Levels on the Development of Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies

Contact Info

Product

Resources

About