Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma

Piacentini, Giorgio; Bodini, Alessandro; Zerman, L.; Costella, Silvia; Zanolla, Luisa; Peroni, Diego; Boner, Attilio

doi:10.1183/09031936.02.00237702

Cited by 51 publications

(81 citation statements)

References 18 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of DeuT as a parameter to characterise the exhaled breath temperature curve allowed us to show that asthmatic patients have higher DeuT values compared to those in normal subjects, possibly reflecting airway inflammation and bronchial blood flow. Contrary to what was shown in the study by PIACENTINI et al[1], we were not able to show any correlation between PLET and exhaled NO, and PLET was not significantly different in asthmatic compared to normal subjects, confirming that DeuT is a better parameter to characterise the curve.In addition, we are surprised to see that the PIACENTINI et al [1]. managed to separate the PET from the PLET, as they coincide in our tracings ( fig.…”

mentioning

confidence: 62%

“…

We read with interest the manuscript of PIACENTINI et al [1]. This paper shows that exhaled breath temperature plateau and exhaled nitric oxide (NO) are correlated in children with asthma.

This finding is interesting considering that NO is a marker of inflammation and that exhaled breath temperature may also be used to assess inflammation in the airways in a noninvasive way.

…”

mentioning

confidence: 63%

See 1 more Smart Citation

Exhaled breath temperature in asthma: Fig. 1.—

Paredi¹,

Kharitonov²,

Barnes³

2003

Eur Respir J

View full text Add to dashboard Cite

We read with interest the manuscript of PIACENTINI et al. [1]. This paper shows that exhaled breath temperature plateau and exhaled nitric oxide (NO) are correlated in children with asthma.This finding is interesting considering that NO is a marker of inflammation and that exhaled breath temperature may also be used to assess inflammation in the airways in a noninvasive way. We previously showed a similar correlation between exhaled NO and breath temperature in adults [2]. However, we measured the rate of exhaled breath temperature increase (DeuT) rather than the peak expiratory temperature (PET) and the plateau temperature (PLET) measured in this study. The use of DeuT as a parameter to characterise the exhaled breath temperature curve allowed us to show that asthmatic patients have higher DeuT values compared to those in normal subjects, possibly reflecting airway inflammation and bronchial blood flow. Contrary to what was shown in the study by PIACENTINI et al.[1], we were not able to show any correlation between PLET and exhaled NO, and PLET was not significantly different in asthmatic compared to normal subjects, confirming that DeuT is a better parameter to characterise the curve.In addition, we are surprised to see that the PIACENTINI et al. [1]. managed to separate the PET from the PLET, as they coincide in our tracings ( fig. 1).Furthermore, the authors failed to recognise thatDeuT and plateau are dependent on the exhalation flow rate [2]. The children were asked to perform a "slow expiratory act" but the exhalation flow rate was not standardised, making the results unreliable. Moreover, the mouth pressure generated during exhalation should be determined to confirm that the soft palate was effectively closed avoiding contamination of the exhaled breath with nasal air. In addition, the intersession and intrasession reproducibility of the method was not investigated.The lack of standardisation of the method may explain some of the unexpected findings in this paper, such as the failure of steroids to decrease exhaled breath temperature despite their efficacy in reducing bronchial blood flow [3]. Furthermore, exhaled NO levels were similar in steroid-treated and untreated children, whereas it is well established that steroids effectively reduce the levels of exhaled NO [4, 5].We feel that the methodological inexactitudes and the unexpected findings deserve a comment by the authors, which was not provided in the paper as published.

show abstract

mentioning

confidence: 62%

“…

We read with interest the manuscript of PIACENTINI et al [1]. This paper shows that exhaled breath temperature plateau and exhaled nitric oxide (NO) are correlated in children with asthma.

This finding is interesting considering that NO is a marker of inflammation and that exhaled breath temperature may also be used to assess inflammation in the airways in a noninvasive way.

…”

mentioning

confidence: 63%

Exhaled breath temperature in asthma: Fig. 1.—

Paredi¹,

Kharitonov²,

Barnes³

2003

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Rigorous control of the external temperature was a concern in studies using other methods. (7,8) Due to the small number of patients investigated in the present study, we still cannot affirm that the measurement of EBT is a valid biological marker for the evaluation of asthma control. However, this measurement might constitute a new line of research that, after further studies, might produce a method to be used in routine clinical practice, especially if the device employed is portable and easy to use.…”

Section: Discussionmentioning

confidence: 78%

“…(25) Although the first studies of the physiology of heat exchange in the respiratory tree date from the 1960s and studies of the evolution of the observation of the differences in the temperature in each bronchial segment-as well as the relationship between these differences and the inhaled breath temperature-date from the 1980s, (26) the first studies involving direct measurements of EBT were not conducted until the beginning of the 21st century. (7,8) The first studies of exhaled air, which were published in 2002, (7,8) compared the measurements of two markers: temperature and NO. The initial impression of the authors of those studies was sputum requires specific knowledge and techniques in order to be effectively applied.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Temperatura do ar exalado, um novo biomarcador no controle da asma: um estudo piloto

2010

View full text Add to dashboard Cite

Objective: To evaluate whether the exhaled breath temperature (EBT), measured by a noninvasive method, is an effective means of monitoring patients with uncontrolled asthma. Methods: A pilot study comprising nine patients (seven women and two men; mean age: 39 years) diagnosed with asthma at least one year prior to the beginning of the study and not having been under maintenance therapy for the last three months. In the first visit, the patients underwent spirometry and measurement of EBT. The patients were then instructed to use inhaled budesonide/formoterol (200/6 µg) every 12 h for six weeks. In addition, the patients with severe asthma (FEV 1 < 60% of predicted) were instructed to use oral prednisolone (40 mg/day) for five days. After six weeks, the patients underwent the same tests. Results: All of the patients reported an improvement in the symptoms of asthma, as confirmed by a statistically significant increase in FEV 1 from the first to the second visit (mean, 56.1% vs. 88.7% of predicted; p < 0.05). Five patients used oral prednisolone for the first five days of the treatment period. Six patients used additional doses of inhaled budesonide/formoterol (mean duration, 2.5 weeks). The EBT decreased significantly from the first to the second visit (mean EBT: 35.1°C vs. 34.1°C; p < 0.05). Conclusions: Uncontrolled asthma, especially during exacerbations, is followed by an increase in EBT, which decreases after appropriate asthma control, as demonstrated by an increase in FEV 1 and an improvement of the reported symptoms. These preliminary results suggest that EBT can be used as a parameter for the assessment of asthma control.Keywords: Asthma; Biomarkers, pharmacological; Hydroxycorticosteroids. ResumoObjetivo: Avaliar se a temperatura do ar exalado (TAE), medida por um método não invasivo, é efetiva no monitoramento de pacientes com asma não controlada. Métodos: Estudo piloto com nove pacientes (sete mulheres e dois homens; média de idade: 39 anos) com diagnóstico de asma por pelo menos um ano e sem uso de tratamento de manutenção por pelo menos três meses antes do início do estudo. Na primeira visita, os pacientes foram submetidos à espirometria e à medida da TAE. Todos os pacientes foram orientados a iniciar tratamento com budesonida/formoterol (200/6 µg) inalatório a cada 12 h por seis semanas. Além disso, os pacientes com asma grave (VEF 1 < 60% do previsto) foram orientados a utilizar prednisolona oral (40 mg/dia) por cinco dias. Após seis semanas, os pacientes foram submetidos aos mesmos testes. Resultados: Todos os pacientes relataram melhora dos sintomas de asma; confirmada por um aumento significativo de VEF 1 da primeira para a segunda visita (média de VEF 1 : 56,1% vs. 88,7% do previsto; p < 0,05). Cinco pacientes utilizaram prednisolona oral, mas somente nos cinco dias iniciais do tratamento. Seis pacientes utilizaram doses extras da medicação inalatória (média de tempo de uso de medicação adicional = 2,5 semanas). Houve uma diminuição significativa da TAE entre os momentos de avaliação ...

show abstract

The Application of Analytical Technique Applied to Expired Air as a Means of Monitoring Airway and Lung Function

Paredi¹,

Barnes²

2020

Cotes’ Lung Function

View full text Add to dashboard Cite

Relationship between exhaled air temperature and exhaled nitric oxide in childhood asthma

Cited by 51 publications

References 18 publications

Exhaled breath temperature in asthma: Fig. 1.—

Exhaled breath temperature in asthma: Fig. 1.—

Temperatura do ar exalado, um novo biomarcador no controle da asma: um estudo piloto

The Application of Analytical Technique Applied to Expired Air as a Means of Monitoring Airway and Lung Function

Contact Info

Product

Resources

About