Relationship between Exercise-Induced Bronchospasm (EIB) and Asthma Control Test (ACT) in Asthmatic Children

Rapino, Daniele; Np, Consilvio; Scaparrotta, Alessandra; Cingolani, Anna; Attanasi, Marina; S, Di Pillo; Verini, M; Chiarelli, Francesco

doi:10.3109/02770903.2011.631242

Cited by 18 publications

(16 citation statements)

References 14 publications

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“…The lack of concordance between ACT results and AHR is in agreement with the literature [21,22], whereas there was no information or studies published about ATAQ.…”

Section: Discussionsupporting

confidence: 85%

“…In particular, no studies have been carried out to study the same population with both questionnaires and comparing the two questionnaires with a validated stress test [21,22]. This is an important feature to investigate due to the fact that stress tests have been shown to be useful in evaluating asthma control and the efficacy of asthma therapy as indicated in the PRACTALL consensus [10].…”

Section: Discussionmentioning

confidence: 99%

“…However, another study has shown that ACT does not improve its specificity in achieving airway hyperresponsiveness even adding in the questionnaire a sixth question specifically aimed at detecting exercise-induced asthma confirming that this questionnaire is not able to determine whether a child has AHR or not [21]. …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of association between airway hyperresponsiveness, asthma control test, and asthma therapy assessment questionnaire in asthmatic children

Rapino

Attanasi

Consilvio

et al. 2013

Multidiscip Respir Med

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BackgroundAchieving asthma control is a major challenge in children, otherwise symptoms perception remain poor especially at this age. The aim of this study is to evaluate the relationship between Asthma Control Test (ACTTM), Asthma Therapy Assessment Questionnaire (ATAQTM) and exercise-induced bronchospasm (EIB).MethodsWe studied 80 asthmatic children. Airways hyperresponsiveness (AHR) was assessed by exercise-induced bronchospasm (Balke Protocol). Asthma control was evaluated using two questionnaires in all subjects: ACT (composed by Childhood-ACT and ACT) and ATAQ. In addition the use of short acting beta 2 agonist agents (SABAs) was assessed for each patient. Non-parametric variables were compared by Chi Square Test. Binomial logistic regression was performed to estimate the two questionnaires Odds Ratio (OR) in finding AHR.ResultsWe have found that ATAQ has a sensitivity and a specificity of 0.72 and 0.45 respectively; instead, ACT has a sensitivity and a specificity of 0.5 and 0.39 respectively in evaluating AHR. Patients with uncontrolled asthma according to ATAQ revealed a significant higher percentage of AHR compared with ACT (72% vs 50%, p < 0.01).Confirming this finding, patients declaring uncontrolled asthma to ATAQ have a significantly higher percentage (34%) of frequent SABAs use than the group with uncontrolled asthma to ACT (21%) (p <0.01).Binomial logistic regression shows how a test revealing uncontrolled asthma is associated with the increasing odds of having AHR according to ATAQ (OR = 3.8, p = 0.05), not to ACT (OR = 0.2, p = 0.1).ConclusionsOur results show that ATAQ reflects AHR and asthma control better than ACT. Children with uncontrolled asthma according to ATAQ have higher odds of having AHR and use of rescue medications (SABAs) compared to patients declaring uncontrolled asthma according to ACT. However both questionnaires are not sufficient alone to fully evaluate asthma control in children and it is always necessary to perform functional tests and investigate patients lifestyle, drug use and other important data that a simple questionnaire is not able to point out

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“…The lack of concordance between ACT results and AHR is in agreement with the literature [21,22], whereas there was no information or studies published about ATAQ.…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of association between airway hyperresponsiveness, asthma control test, and asthma therapy assessment questionnaire in asthmatic children

Rapino

Attanasi

Consilvio

et al. 2013

Multidiscip Respir Med

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“…However, our results are in concordance with previous studies that showed no difference in pre‐exercise FEV 1 between EIB‐positive and negative groups . Although, asthmatics had diverse asthma control, supporting the previous studies, asthma control was not related to EIB. The exact pathology of EIB is still unclear.…”

Section: Discussionsupporting

confidence: 92%

Exhaled breath condensate pH decreases during exercise‐induced bronchoconstriction

et al. 2014

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“…Rapino et al found a similar percentage of EIB in children with complete, partial or poor asthma control according to the ACT, i.e. 36% of children that report complete asthma control develop EIB during a treadmill exercise challenge [17]. Madhuban et al found no relationship between the categorical ACQ and the occurrence of EIB and a positive challenge test in 41% of asthmatic children reporting well-controlled asthma according to the ACQ [16].…”

Section: Discussionmentioning

confidence: 99%

Reported Exercise-Related Respiratory Symptoms and Exercise-Induced Bronchoconstriction in Asthmatic Children

et al. 2017

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BackgroundUnlimited physical activity is one of the key issues of asthma control and management. We investigated how reliable reported exercise-related respiratory symptoms (ERRS) are in predicting exercise-induced bronchoconstriction (EIB) in asthmatic children.MethodsIn this prospective study, 179 asthmatic children aged 7 - 15 years were asked for specific questions on respiratory symptoms related to exercise and allocated into two groups according to whether they complained about symptoms. Group I (n = 134) consisted of children answering “yes” to one or more of the questions and group II (n = 45) consisted of children answering “no” to all of the questions.ResultsSixty-four of 179 children showed a positive exercise challenge test (ECT). There was no difference in the frequency of a positive test between children in group I (n = 48) and group II (n = 12) (P = 0.47). The sensitivity of a positive report for ERRS to predict a positive ECT was only 37%, with a specificity of 0.72.ConclusionAccording to current guidelines, the report or lack of ERRS has direct consequences on treatment decisions. However, the history of ERRS did not predict EIB and one-third of asthmatic children without complaints of ERRS developed EIB during the ECT. This raises the question of the need for objective measures of bronchial hyperresponsiveness (BHR) in pediatric asthma management.

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Relationship between Exercise-Induced Bronchospasm (EIB) and Asthma Control Test (ACT) in Asthmatic Children

Abstract: It must be stated that ACT alone is not sufficient to evaluate asthma control in children correctly because it fails to detect EIB in a significant percentage of subjects.

Cited by 18 publications

References 14 publications

Evaluation of association between airway hyperresponsiveness, asthma control test, and asthma therapy assessment questionnaire in asthmatic children

Evaluation of association between airway hyperresponsiveness, asthma control test, and asthma therapy assessment questionnaire in asthmatic children

Exhaled breath condensate pH decreases during exercise‐induced bronchoconstriction

Reported Exercise-Related Respiratory Symptoms and Exercise-Induced Bronchoconstriction in Asthmatic Children

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