Relationship between Exercise Capacity and Ventilatory Equivalent for Carbon Dioxide in Patients with Stable Old Myocardial Infarction.

Kimura, Masahiro; Haraguchi, Masahiko; Fujii, Kaori; Harada, Masahiko; Ono, Kaoru; Kubo, Makoto; Tada, Takashi; Matsuda, Masako; Matsuzaki, Masunori

doi:10.1536/jhj.40.127

Cited by 5 publications

(8 citation statements)

References 24 publications

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“…Recent studies indicate that the carbon dioxide equivalent (VE / VCO 2 ) slope during incremental exercise is a valid prognostic indicator for the reoccurrence of cardiovascular events in CAD patients [18] . In accordance with these fi ndings, the exercise VE / VCO 2 slope is steeper in CAD patients, as compared to healthy age-matched controls [10] . Because maximal exercise per-The exercise carbon dioxide equivalent slope predicts prognosis in coronary artery disease patients.…”

Section: Introductionsupporting

confidence: 83%

Type of Exercise Alters VE/VCO₂Slope in CAD Patients

Hansen¹,

Dendale²,

Berger³

2009

Int J Sports Med

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The exercise carbon dioxide equivalent slope predicts prognosis in coronary artery disease patients. However, no study examined whether the carbon dioxide equivalent slope in coronary artery disease patients is dependent on the type of exercise. Twenty-nine coronary artery disease patients performed maximal cardiopulmonary exercise tests on bike, treadmill and arm cycle, with assessment of oxygen uptake, carbon dioxide output, and expiratory volume. The carbon dioxide equivalent slope was calculated from rest till peak exercise. The carbon dioxide equivalent slope was significantly different between walking, cycling, and arm cranking exercises (P<0.05), i.e. the carbon dioxide equivalent slope was the lowest during walking and the highest during arm cranking. Bland-Altman plots revealed that the difference of the carbon dioxide equivalent slope between exercises was greater in the case of a higher averaged carbon dioxide equivalent slope and overall peak oxygen uptake. In conclusion, the carbon dioxide equivalent slope is significantly dependent on the type of exercise in coronary artery disease patients. Additionally, the averaged carbon dioxide equivalent slope and peak oxygen uptake affect the difference of the carbon dioxide equivalent slopes between exercises.

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Section: Introductionsupporting

confidence: 83%

Type of Exercise Alters VE/VCO₂Slope in CAD Patients

Hansen¹,

Dendale²,

Berger³

2009

Int J Sports Med

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“…The patients were classified into 3 groups according to peak V • O2, as previously reported: 6 (i) OMI class 0: peak V…”

Section: Methods Of Exercise Testingmentioning

confidence: 99%

“…[12][13][14][15] We calculated the SLOPE below the AT in each subject 6 with the method we had reported. 6 We eliminated subjects who were unable to exercise beyond the AT.…”

Section: Methods Of Exercise Testingmentioning

confidence: 99%

“…[12][13][14][15] We calculated the SLOPE below the AT in each subject 6 with the method we had reported. 6 We eliminated subjects who were unable to exercise beyond the AT. The subjects' ECG and heart rate were monitored (Exercise testing system CASE 16, MARQUETTE Electronics Inc, Milwaukee, WI, USA) and arterial oxygen saturation was measured with pulse oximetry (PULSOX-3, Minolta Co Ltd, Osaka, Japan) during the exercise testing.…”

Section: Methods Of Exercise Testingmentioning

confidence: 99%

“…[5][6][7][8][9] Furthermore, SLOPE is an index of ventilatory -perfusion inequality. 6,9 Few studies have investigated the relationship between exercise capacity and SLOPE in patients with pulmonary hypertension (PH), so we examined the relationship between exercise capacity and SLOPE in patients with PH, and the differences in ventilatory response between them and patients with a stable old myocardial infarction (OMI). We also discuss the meaning of the exercise tolerance test in PH patients.…”

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confidence: 99%

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Excessive Ventilatory Response During Exercise in Patients With Non-Hypoxic Pulmonary Hypertension.

Mitani

Haraguchi

Takata

et al. 2002

Circ J

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e can evaluate exercise capacity by oxygen consumption (V • O2), carbon dioxide output (V • CO2) and minute ventilation (V • E), [1][2][3][4] and the slope of the linear regression line between V• CO2 and V • E (SLOPE) is a useful parameter for indicating exercise capacity in chronic heart failure patients. [5][6][7][8][9] Furthermore, SLOPE is an index of ventilatory -perfusion inequality. 6,9 Few studies have investigated the relationship between exercise capacity and SLOPE in patients with pulmonary hypertension (PH), so we examined the relationship between exercise capacity and SLOPE in patients with PH, and the differences in ventilatory response between them and patients with a stable old myocardial infarction (OMI). We also discuss the meaning of the exercise tolerance test in PH patients. MethodsPatient Population (Table 1) Patients With Pulmonary Hypertension Eight patients with PH in series were recruited. Their mean age was 57±5 years (range, 22-68 monary thromboembolism were diagnosed by the criteria and description from textbooks. 10,11 Two female patients had PPH; pulmonary scintigraphy demonstrated only shallow subpleural perfusion deficits and pulmonary angiography could not detect significant thrombosis. The other 6 patients (3 male, 3 female) had chronic pulmonary thromboembolism shown by thrombi in proximal pulmonary arteries on pulmonary angiograms.According to echocardiography, all the patients had a normal left ventricular ejection fraction and none had wall motion asynergy. There were no significant disorders of the aortic or mitral valves.All of the patients were clinically stable. They were all receiving diuretics, calcium channel blockers (nifedipine), warfarin and prostaglandin I2 derivative (beraprost), without any change in medication for several months prior to the exercise test. No patient was on diltiazem or verapamil.Patients With OMI Thirty-eight patients with stable OMI (male only) who were not current smokers, were recruited. Their mean age was 52±1 years (range, 38-59) and they were all clinically stable. They were receiving diuretics, digoxin, calcium blockers, or nitrates, and there were no changes in these medications for several months prior to exercise testing. Diltiazem, verapamil, or -blockers were not prescribed for those patients.In the present study, patients who had to cease the exercise test because of cyanosis, anginal pain or ischemic changes on the electrocardiogram (ECG) were excluded. Patients with atrial fibrillation or other various arrhythmias, clinical valvular disorders, severe anemia (hemoglobin <12 g/dl), orthopedic disorders, obesity (body mass index (BMI) The slope of the regression line between carbon dioxide output (V • CO2) and minute ventilation (V • E) (SLOPE) is useful for evaluating ventilation -perfusion inequality during exercise. A cardiopulmonary exercise test was carried out in 8 pulmonary hypertension (PH) patients without hypoxemia (group PH), 38 male patients with old myocardial infarction (group OMI), and 20 healthy men (group Ctrl). ...

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Relationship Between Ventilatory Expired Gas and Cardiac Parameters During Symptom-Limited Exercise Testing in Patients With Heart Failure

Arena

Humphrey

2001

Journal of Cardiopulmonary Rehabilitation

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Relationship between Exercise Capacity and Ventilatory Equivalent for Carbon Dioxide in Patients with Stable Old Myocardial Infarction.

Cited by 5 publications

References 24 publications

Type of Exercise Alters VE/VCO₂Slope in CAD Patients

Type of Exercise Alters VE/VCO₂Slope in CAD Patients

Excessive Ventilatory Response During Exercise in Patients With Non-Hypoxic Pulmonary Hypertension.

Relationship Between Ventilatory Expired Gas and Cardiac Parameters During Symptom-Limited Exercise Testing in Patients With Heart Failure

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Relationship between Exercise Capacity and Ventilatory Equivalent for Carbon Dioxide in Patients with Stable Old Myocardial Infarction.

Cited by 5 publications

References 24 publications

Type of Exercise Alters VE/VCO2Slope in CAD Patients

Type of Exercise Alters VE/VCO2Slope in CAD Patients

Excessive Ventilatory Response During Exercise in Patients With Non-Hypoxic Pulmonary Hypertension.

Relationship Between Ventilatory Expired Gas and Cardiac Parameters During Symptom-Limited Exercise Testing in Patients With Heart Failure

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Type of Exercise Alters VE/VCO₂Slope in CAD Patients

Type of Exercise Alters VE/VCO₂Slope in CAD Patients