Relationship Between Exercise Capacity and Clinical Measures in Patients with Chronic Obstructive Pulmonary Disease

Bavarsad, Maryam Bakhshandeh; Shariati, Abdolali; Eidani, Esmail; Latifi, Seyed Mahmoud

doi:10.13005/bpj/548

Cited by 1 publication

(4 citation statements)

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“…Very limited data were found concerning associations between the SGRQ symptom domain score (SGRQ symptom ) and exercise test outcomes ( Table 2 ). Five studies 46 , 50 , 53 , 55 , 60 of seven 37 , 46 , 50 , 53 , 55 , 59 , 60 assessing the association between SGRQ symptom and 6MWT distance reported nonsignificant relationships. In the two studies that reported significant correlations between SGRQ symptom and 6MWT, very weak negative (−0.03) 37 and weak negative (−0.35) 59 correlations were found.…”

Section: Resultsmentioning

confidence: 93%

“… 37 , 41 – 43 , 45 , 46 , 49 , 50 , 52 , 53 , 55 , 59 , 60 Of these, correlations between outcomes from the SGRQ total and distance covered in the 6MWT were most commonly reported. These correlations were typically significant, with six articles reporting weak negative Pearson’s correlations of −0.26, 37 −0.26 ( P <0.01), 59 −0.37 ( P <0.05), 41 −0.37 ( P =0.0228), 49 −0.39 ( P <0.01), 53 and −0.39 ( P =0.01), 60 demonstrating that as distance covered in the 6MWT increases, SGRQ total scores decrease, indicating better health status. There were also two studies reporting Spearman’s correlations of −0.27 42 (JP de Torres confirmed this was incorrectly reported as 0.27 in the article) and −0.56.…”

Section: Resultsmentioning

confidence: 99%

“…Correlations between exercise test outcomes and the SGRQ activity domain score (SGRQ activity ) were reported in nine study publications ( Table 2 ). 37 , 43 , 45 , 46 , 50 , 53 , 55 , 59 , 60 Of these, four articles noted significant weak–strong negative correlations between 6MWT distance and SGRQ activity ( r =−0.35, 37 −0.36 53 [weak], and −0.44 60 [moderate]; ρ =−0.68 50 and an unspecified correlation of −0.37 46 ). Two further studies found strong correlations between SGRQ activity and ISWT outcome ( r =−0.67 45 and ρ =−0.62 43 ), with two more finding no significant association for this relationship.…”

Section: Resultsmentioning

confidence: 99%

“…Correlations between exercise test outcomes and the SGRQ impact domain score (SGRQ impact ) were reported in nine articles ( Table 2 ). 37 , 43 , 45 , 46 , 50 , 53 , 55 , 59 , 60 Five studies found weak–moderate correlations between the SGRQ impact and the 6MWT ( r =−0.22, −0.28, −0.37, 37 , 53 , 59 and 0.4; 60 ρ =−0.5 55 ), two found moderate evidence for an association between the SGRQ impact and the ISWT ( r =−0.53 45 and ρ =−0.48 43 ), and there was moderate evidence for an association between the SGRQ impact and the ECET ( ρ =−0.50) 50 or TT ( ρ =−0.54). 43 A further study found a weak correlation between the SGRQ impact and the ICET W max ( r =−0.20).…”

Section: Resultsmentioning

confidence: 99%

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Systematic review of the association between exercise tests and patient-reported outcomes in patients with chronic obstructive pulmonary disease

Punekar

Riley

Lloyd

et al. 2017

COPD

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Introduction Chronic obstructive pulmonary disease (COPD) is an increasingly common cause of death worldwide. Its cardinal symptoms include breathlessness and severely reduced exercise capacity. Several patient-reported outcome (PRO) measures are used to assess health-related quality of life (HRQoL), functional performance, and breathlessness in patients with COPD. Exercise testing is employed to measure functional performance objectively, which is generally believed to impact on overall HRQoL. However, the extent to which commonly used laboratory- and field-based exercise test results correlate with PROs has not been systematically assessed. Materials and methods A search of Embase, MedLine, and the Cochrane Library identified primary publications in English that reported data on the correlations (Pearson’s r or Spearman’s ρ ) between the outcomes of exercise tests and HRQoL and breathlessness PROs. Studies reporting on the following tests were included: 6-minute walk test (6MWT), 12MWT, incremental and endurance shuttle walk tests, incremental and endurance cycle ergometer tests, and treadmill tests. Results Of 3,205 articles screened, 28 were deemed eligible for inclusion. The most commonly reported HRQoL PRO measure was the St George’s Respiratory Questionnaire (13 studies), and the most commonly reported breathlessness PRO measure was the Baseline Dyspnea Index (six studies). The St George’s Respiratory Questionnaire appears to correlate very weakly to moderately with the 6MWT, and breathlessness PROs appear to be moderately to strongly associated with 6MWT outcomes. Across all studies, the 6MWT was the most commonly reported exercise test. Very few publications reporting associations between other exercise tests and PRO measures were found. Conclusion This review found evidence to support the association of 6MWT outcomes with HRQoL and breathlessness PROs. There were limited data showing correlations with the outcomes of other exercise tests. Further work is required to examine the associations between these PROs and exercise test outcomes.

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