Relationship between exercise capacity and cardiac diastolic function assessed by time–volume curve from 16-frame gated myocardial perfusion SPECT

Yoshino, Tomohide; Nakae, Ichiro; Matsumoto, Tetsuya; Mitsunami, Kenichi; Horie, Minoru

doi:10.1007/s12149-010-0382-x

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…however, previous studies indicated that LV diastolic dysfunction rather than systolic function is associated with exercise intolerance (30,31), and PhHB/PhSD are related to diastolic function as described above. Although the mechanisms underlying the relationship between diastolic function and exercise capacity have not yet been elucidated in detail, previous studies provided some explanations (30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Relationship With Exercise Capacitymentioning

confidence: 80%

“…Moreover, LV diastolic dysfunction may be related to skeletal muscle weakness (36), particularly inspiratory muscle weakness (37), causing dyspnea and tachypnea during exercise. We discussed these matters in our previous study (31).…”

Section: Relationship With Exercise Capacitymentioning

confidence: 96%

“…Although the mechanisms underlying the relationship between diastolic function and exercise capacity have not yet been elucidated in detail, previous studies provided some explanations (30)(31)(32)(33)(34)(35)(36)(37). In tachycardia induced by exercise, abnormalities in LV diastolic relaxation and filling may limit the ability to achieve adequate cardiac output, even if systolic function is preserved (32).…”

Section: Relationship With Exercise Capacitymentioning

confidence: 99%

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Utility of Phase Standard Deviation and Histogram Bandwidth, Derived from Phase Analysis, as Clinical Indicators of Heart Failure

Tomita

Nakae

Hayashi

et al. 2017

Annals of Nuclear Cardiology

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Purpose: "Heart Function View (HFV)" is a software that performs phase analysis as well as functional assessment of the left ventricle (LV) using myocardial perfusion single photon emission computed tomography (SPECT) (MPS). Phase analysis-derived phase standard deviation (PhSD) and histogram bandwidth (PhHB) are good indices for detecting LV dyssyncrony. We aimed to examine whether PhHB and/or PhSD (PhHB/PhSD) are useful clinical indicators that reflect the severity of heart failure (HF) in comparison with the LV ejection fraction (EF). Methods: Patients underwent 99mTc-tetrofosmin quantitative gated MPS including treadmill exercise. In HFV analyses, patients with induced ischemia were excluded. Phase and time-volume curve analyses were performed using HFV (n=66).Results: PhHB/PhSD correlated with LV end-diastolic volume (EDV), end-systolic volume (ESV), the first-third filling fraction (1/3FF), and peak filling rate (PFR) as well as echocardiography tissue Doppler-derived E/e' as hemodynamic parameters of HF severity. LVEF also correlated with these hemodynamic parameters, except for 1/3FF. PhHB/PhSD positively correlated with log BNP as a neurohumoral marker of HF severity. LVEF negatively correlated with log BNP. PhHB/PhSD negatively correlated with exercise capacity as physiological indicators of HF severity, whereas LVEF did not. PhHB/PhSD were significantly greater in patients receiving cardiac resynchronization therapy (CRT, n=6) than in non-CRT patients (n=66), whereas LVEF were lower. Conclusion: PhHB/PhSD, similar to LVEF, are useful clinical indicators for evaluating HF severity. However, the clinical significance of LVEF and PhHB/PhSD differ. Thus, a phase analysis may additively offer useful information for the management of HF.

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Section: Relationship With Exercise Capacitymentioning

confidence: 80%

Section: Relationship With Exercise Capacitymentioning

confidence: 96%

Section: Relationship With Exercise Capacitymentioning

confidence: 99%

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Utility of Phase Standard Deviation and Histogram Bandwidth, Derived from Phase Analysis, as Clinical Indicators of Heart Failure

Tomita

Nakae

Hayashi

et al. 2017

Annals of Nuclear Cardiology

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“…Note that LAVI was identified as a primary echocardiographic metric relevant to the disablement process described by Verbrugge and Jette (1994).…”

Section: Discussionmentioning

confidence: 99%

“…Diastolic dysfunction is a frequent cause of symptoms in heart failure (Zile, Baicu, & Gaasch, 2004) and is associated with increased mortality (Halley, Houghtaling, Khalil, Thomas, & Jaber, 2011). Moreover, diastolic function appears to correlate with exercise capacity better than systolic function in middle-aged and older patients with heart failure (Gardin et al, 2009; Yoshino, Nakae, Matsumoto, Mitsunami, & Horie, 2010). …”

mentioning

confidence: 99%

Left Atrial Enlargement and Reduced Physical Function During Aging

Pellett¹,

Myers²,

Welsch³

et al. 2013

Journal of Aging and Physical Activity

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Diastolic dysfunction, often seen with increasing age, is associated with reduced exercise capacity and increased mortality. Mortality rates in older individuals are linked to the development of disability, which may be preceded by functional limitations. The goal of this study was to identify which echocardiographic measures of diastolic function correlate with physical function in older subjects. A total of 36 men and women from the Lou isiana Healthy Aging Study, age 62–101 yr, received a complete echocardiographic exam and performed the 10-item continuous-scale physical-functional performance test (CS-PFP-10). After adjustment for age and gender, left atrial volume index (ρ = −0.59; p = .0005) correlated with the total CS-PFP-10 score. Increased left atrial volume index may be a marker of impaired performance of activities of daily living in older individuals.

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The agreement of left ventricular function parameters between 99mTc-tetrofosmin gated myocardial SPECT and gated myocardial MRI

et al. 2011

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In quantifying of left ventricular function parameter, gated CMR provides similar quantitative values comparing with gated MPS except for ventricular volumes in rest conditions. In contrast, there were certain variations except for LVEF in exercised examinations. When we follow patients by the same cardiac parameters with CMR and MPS, using parameters across the two modalities proved to be possible under rest condition. However, it is limited at exercise condition.

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Relationship between exercise capacity and cardiac diastolic function assessed by time–volume curve from 16-frame gated myocardial perfusion SPECT

Abstract: Our findings suggested that LV diastolic dysfunction, not systolic dysfunction, is associated with limited exercise capacity independent of the occurrence of ischemia.

Cited by 11 publications

References 24 publications

Utility of Phase Standard Deviation and Histogram Bandwidth, Derived from Phase Analysis, as Clinical Indicators of Heart Failure

Utility of Phase Standard Deviation and Histogram Bandwidth, Derived from Phase Analysis, as Clinical Indicators of Heart Failure

Left Atrial Enlargement and Reduced Physical Function During Aging

The agreement of left ventricular function parameters between 99mTc-tetrofosmin gated myocardial SPECT and gated myocardial MRI

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