“…The haplotype analysis and LD testing was based on the online SHEsis ( http://analysis.bio-x.cn/myAnalysis.php ). SNP–SNP interactions were studied using the generalized multifactor dimensionality reduction (MDR) model with three SNPs [ 31 ], and functional annotation was assessed by the Encyclopedia of DNA Elements tool HaploReg v4.2 [ 32 ] to predict the potential SNP functions. The risk associated with individual genotypes or alleles was calculated as the odds ratio (OR) with 95% confidence intervals (95% CIs).…”