Relationship Between Enterococcus faecalis Infective Endocarditis and Colorectal Neoplasm: Preliminary Results From a Cohort of 154 Patients

Pericàs, Juan M.; Corredoira, Juan; Moreno, Asunción; García-Pais, María-José; Falces, Carlos; Rey, Ramón Rabuñal; Mestres, Carlos A.; Alonso, Marı́a Pilar; Marco, Francesc; Quintana, Eduard; Almela, Manel; Paré, Juan C.; Llopis, Jaume; Castells, Antoni; Miró, José M.

doi:10.1016/j.rec.2016.10.013

Cited by 36 publications

(48 citation statements)

References 23 publications

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“…Our findings are supported by several other studies; Sun and colleagues found that patients with IE were at higher risk of underlying colorectal cancer and other malignancies compared with patients without IE . Corredoira and colleagues demonstrated, in their study, that 21% of patients with enterococcal IE had a new colorectal neoplasm, while in another study, colorectal cancer was detected in more than half of patients with E. faecalis endocarditis with an unknown source of infection . Although possible associations between colon cancer and enterococcal endocarditis have been reported in the literature, robust evidence is lacking.…”

Section: Discussionmentioning

confidence: 97%

“…Corredoira and colleagues demonstrated, in their study, that 21% of patients with enterococcal IE had a new colorectal neoplasm, while in another study, colorectal cancer was detected in more than half of patients with E. faecalis endocarditis with an unknown source of infection . Although possible associations between colon cancer and enterococcal endocarditis have been reported in the literature, robust evidence is lacking. We demonstrated high frequencies of underlying diseases involving the gastrointestinal tract, urological tract and cardiovascular system, as well as malignancies in patients with enterococcal bacteraemia, similar to previous studies …”

Section: Discussionmentioning

confidence: 99%

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Enterococcal bacteraemia ‘silent but deadly’: a population‐based cohort study

Cabiltes

Coghill

Bowe

et al. 2020

Internal Medicine Journal

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Background: The high mortality rate of patients with enterococcal infections has been shown to be associated with the severity of underlying comorbidities.Aims: To characterise the epidemiology, clinical characteristics, outcomes and predictors of mortality in patients with enterococcal bacteraemia. Methods:This was a retrospective cohort study of all enterococcal bacteraemia episodes in the Barwon region between January 2010 and March 2017. We assessed the epidemiology, clinical characteristics, outcomes and predictors of mortality using descriptive statistics and simple and multiple logistic regression analyses.Results: The incidence of enterococcal bacteraemia was 19.9/100 000 person-years.Males comprised 68.4%, and the median age was 71 years. Common comorbidities were gastrointestinal tract disease, urological disease, malignancies and cardiovascular disease. Infective endocarditis was observed in 15% of patients, and 1 of 27 also had colorectal cancer. Twelve patients referred for colonoscopy demonstrated previously undiagnosed colorectal neoplasia in 75% of these cases. The 30-day and 1-year mortality rates were 11.7 and 40.2% respectively. Sixty-nine cases with vancomycin-resistant Enterococcus were observed. Multiple logistic regression suggested that the presence of underlying urological malignancy (adjusted odds ratio = 3.57, 95% confidence intervals = 1.10-11.65, P = 0.035) and colorectal cancer (adjusted odds ratio = 4.47, 95% confidence intervals = 1.36-14.66, P = 0.014) were significant predictors of 1-year mortality.Conclusions: Microbiological cure was inversely associated with 30-day mortality. The presence of underlying urological and colorectal malignancy was a predictor of 1-year mortality. We identified the importance of evaluating patients with Enterococcus faecalis bacteraemia for underlying colorectal neoplasia. Routine colonoscopy is recommended in patients with E. faecalis bacteraemia or infective endocarditis with an unclear source of infection. AbstractBackground: Activity-based funding (ABF) is a means of healthcare reimbursement, where hospitals are allocated funding based on the number and mix of clinical activity. The ABF model is based solely on Australian refined diagnosis-related group (AR-DRG) classifications of hospital encounters. Each AR-DRG is allocated a weighted activity unit (WAU) translating to cost value to determine ongoing funding allocations for each hospital annually.Aim: We explored cost consequences of AR-DRG coding variances within our Medical Oncology department over a 6-month period.Methods: All inpatient encounters for medical oncology from 1 January to 30 June 2014 were identified and paired with actual AR-DRG coding sheets submitted by the hospital coders. Inpatient charts were manually reviewed by a Medical Oncology Registrar to capture any changes or additional AR-DRGs, which were subsequently evaluated for total WAU value variance. Applying 1 WAU = $4676 as per the 2014 Queensland model, cost consequences were calculated.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Enterococcal bacteraemia ‘silent but deadly’: a population‐based cohort study

Cabiltes

Coghill

Bowe

et al. 2020

Internal Medicine Journal

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“…Some of the LPXTG surface proteins, including Spa, FnbpA, FnbpB, ClfA, ClfB and other microbial surface components recognizing adhesive matrix molecules (MSCRAMMs), are directly linked with biofilm formation [ 7 , 8 , 9 , 10 , 11 ]. Bacterial ability to form biofilms allows them to colonize inert substrates (e.g., implantable medical devices) thus causing infections that are difficult to treat because the biofilm matrix and phenotypic characteristics of the bacteria confer resistance to both the host immune response and the action of antimicrobial drugs [ 9 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking

et al. 2017

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Sortase A inhibition is a well establish strategy for decreasing bacterial virulence by affecting numerous key processes that control biofilm formation, host cell entry, evasion and suppression of the immune response and acquisition of essential nutrients. A meta-analysis of structures known to act as Sortase A inhibitors provided the starting point for identifying a new potential scaffold. Based on this template a series of new potential Sortase A inhibitors, that contain the 2-phenylthiazole moiety, were synthesized. The physicochemical characterisation confirmed the identity of the proposed structures. Antibacterial activity evaluation showed that the new compounds have a reduced activity against bacterial cell viability. However, the compounds prevent biofilm formation at very low concentrations, especially in the case of E. faecalis. Molecular docking studies performed estimate that this is most likely due to the inhibition of Sortase A. The new compounds could be used as add-on therapies together with known antibacterial agents in order to combat multidrug-resistance enterococcal infections.

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“…Regarding E. faecalis , it is believed that this agent is also involved in the mutation of colonic cells [ 13 ]. Some studies defend that the lesioned mucosa, be it due to ischemia or inflammation, is propitious to translocation of agents such as E. faecalis , leading to bacteremia [ 2 , 9 , 14 ]. It is known that the presence of a previous mitral prolapse predisposes to the onset of endocarditis caused by this microorganism.…”

Section: Discussionmentioning

confidence: 99%

Infectious Endocarditis from Enterococcus faecalis Associated with Tubular Adenoma of the Sigmoid Colon

Silva

Montalvão

Bonafé

2017

Case Reports in Infectious Diseases

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Introduction Enterococcus faecalis (E. faecalis), a constituent of the gut microbiota, can be associated with both colonic lesions and endocarditis. Since this microorganism is one of the endocarditis etiological agents, there is a need for greater study in regard to the association with endocarditis and colonic lesions. Case Presentation This is the case description of a 53-year-old man with history of prolapse of the anterior mitral valve leaflet who was diagnosed with endocarditis by E. faecalis and treated with ampicillin and gentamicin. Upon investigation by colonoscopy, he was found to have a tubular adenoma with low grade dysplasia. Conclusion There are a few descriptions in scientific literature of an association between endocarditis by E. faecalis and colonic lesions. However, further studies with significant correlation between the two pathologies are required, so that proper measures can be implemented in clinical practice.

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Relationship Between Enterococcus faecalis Infective Endocarditis and Colorectal Neoplasm: Preliminary Results From a Cohort of 154 Patients

Cited by 36 publications

References 23 publications

Enterococcal bacteraemia ‘silent but deadly’: a population‐based cohort study

Enterococcal bacteraemia ‘silent but deadly’: a population‐based cohort study

New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking

Infectious Endocarditis from Enterococcus faecalis Associated with Tubular Adenoma of the Sigmoid Colon

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