Relationship between Endothelial Cell Markers and Arterial Stenosis in Peripheral and Carotid Artery Disease

Blann, Andrew D.; Farrell, Anne G.; Picton, Andy; McCollum, Charles

doi:10.1016/s0049-3848(99)00156-5

Cited by 45 publications

(32 citation statements)

References 36 publications

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“…We were unable to demonstrate such an association. In keeping with our results, Blann et al [30] were unable to demonstrate a relationship between increased levels of sICAM-1 and the severity of carotid artery disease in patients presenting with a TIA. A previous study that looked at the relationship between the degree of internal carotid artery stenosis and sICAM-1 level found an inverse relationship [28].…”

Section: Discussionsupporting

confidence: 89%

Predictive Value of Soluble Intercellular Adhesion Molecule-1 for Risk of Ischemic Events in Individuals with Cerebrovascular Disease

et al. 2005

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Background and Purpose: Cellular adhesion molecules may play a critical role in the inflammatory process leading to atherosclerosis. The purpose of this study was to determine whether soluble intercellular adhesion molecule-1 (sICAM-1) is a predictor of future ischemic events in high-risk individuals and also whether it is associated with carotid artery stenosis. Methods: We conducted a prospective study of sICAM-1 concentration in 3 groups: (1) subjects with recent (<7 days) ischemic stroke or TIA, (2) asymptomatic subjects with carotid stenosis ≧ 50% and (3) asymptomatic individuals with vascular risk factors. Subjects were followed for a minimum of 3 years. sICAM-1 levels were compared between the groups and correlated with the risk of ischemic events and the degree of carotid artery stenosis. Results: We studied 275 subjects. Mean sICAM-1 levels were significantly higher in those with recent ischemic stroke or TIA compared to those with risk factors alone. During follow-up, ischemic events occurred almost nine times more frequently in subjects in group 1 compared to group 3. sICAM-1 concentration was not predictive of future ischemic events (OR 1.001, 95% CI 0.998–1.004). There was no significant association between sICAM-1 concentration and carotid artery stenosis (OR 1.001, 95% CI 0.999–1.004). Conclusions: Mean sICAM-1 levels were higher in subjects with recent cerebral ischemia. No association between sICAM-1 and carotid artery stenosis was observed. Neither baseline nor subsequent sICAM-1 levels were predictive of the risk of future ischemic events.

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Section: Discussionsupporting

confidence: 89%

Predictive Value of Soluble Intercellular Adhesion Molecule-1 for Risk of Ischemic Events in Individuals with Cerebrovascular Disease

et al. 2005

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“…Very recently, in a study of van der Meer I et al 38 performed in a general population, ICAM-1 levels were strongly associated with carotid plaques, while VCAM-1 was not significantly associated with any measure of atherosclerosis. However, Blann et al 39 were unable to observe any correlation between ICAM-1 and percent stenosis of the carotid artery in patients either with transient ischaemic attack or intermittent claudication. Otsuki et al 40 could observe a positive correlation between plasma VCAM-1 concentrations and intima-media thickness of the carotid arteries in NIDDM.…”

Section: Carotid Artery Structure and Adhesion Moleculesmentioning

confidence: 91%

Circulating adhesion molecules and carotid artery structural changes in patients with noninsulin-dependent diabetes mellitus

et al. 2003

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Hypertension and non insulin-dependent diabetes mellitus (NIDDM) are well-known risk factors for atherosclerotic disease. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) may exert a relevant role in the pathogenesis of atherosclerosis; their prognostic relevance has been recently demonstrated. The aim of the study was to investigate possible inter-relation between circulating adhesion molecule levels, carotid artery structure and endothelial function in 15 patients with NIDDM, as well as in 15 patients with both NIDDM and essential hypertension (NIDDM+EH) compared with 15 normal subjects (NS) and 15 euglycaemic patients with EH, matched for age, sex and body weight. All subjects were submitted to a biopsy of the gluteal subcutaneous fat. Small arteries were dissected and mounted on a micromyograph, and the media-to-lumen (M/L) ratio was then calculated. Carotid artery structure was investigated by Doppler ultrasound. Endothelial function was evaluated by investigation of the flow-mediated dilatation (FMD) of the brachial artery. ICAM-1 and VCAM-1 plasma levels were measured by ELISA. ICAM-1 and VCAM-1 plasma levels were significantly greater and FMD smaller in EH, NIDDM and NIDDM+EH than in NS, but no difference was observed among the three pathological groups. Carotid artery structural changes were more pronounced in NIDDM+EH. No significant difference was observed among NIDDM, EH and NS. The M/L ratio of subcutaneous small resistance arteries was significantly greater in NIDDM+EH than in NIDDM or EH. NS had a smaller M/L ratio than the other groups. Significant correlations were observed between ICAM-1 plasma levels and indices of carotid artery structure in diabetic patients. However, the relations were close only in NIDDM+EH. In conclusion, our data suggest that NIDDM+EH may present more pronounced vascular structural alterations than NIDDM, and that adhesion molecules plasma levels are closely inter-related with carotid artery structural alterations, at least in NIDD-M+EH, but not with M/L ratio of small resistance arteries.

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“…The primary changes in the proposed method are the use of a guard cartridge for trapping cortisol as part of an online purification strategy and the use of step gradient Clinical Chemistry 49, No. 6,2003 rather than isocratic LC conditions. Both electrospray ionization (ESI) and atmospheric pressure ionization (APCI) are well suited for LC-MS/MS.…”

mentioning

confidence: 99%

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Urinary Free Cortisol

et al. 2003

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Relationship between Endothelial Cell Markers and Arterial Stenosis in Peripheral and Carotid Artery Disease

Cited by 45 publications

References 36 publications

Predictive Value of Soluble Intercellular Adhesion Molecule-1 for Risk of Ischemic Events in Individuals with Cerebrovascular Disease

Predictive Value of Soluble Intercellular Adhesion Molecule-1 for Risk of Ischemic Events in Individuals with Cerebrovascular Disease

Circulating adhesion molecules and carotid artery structural changes in patients with noninsulin-dependent diabetes mellitus

Liquid Chromatography–Tandem Mass Spectrometry Analysis of Urinary Free Cortisol

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