Relationship between endogenous 3-methylhistidine excretion and body composition

Lukaski, Henry C.; Méndez, José; Buskirk, E. R.; Cohn, S. H.

doi:10.1152/ajpendo.1981.240.3.e302

Cited by 47 publications

(47 citation statements)

References 20 publications

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“…At a cellular level, estimates of total body muscle can be obtained from endogenous metabolites of skeletal muscle, such as creatinine, 3-methylhistidine, urinary creatinine excretion, and D3-creatine. Creatinine is produced at a relatively constant daily rate from non-enzymatic changes in creatine (15), whereas 3-methylhistidine derives from the breakdown of actomyosin (16).…”

Section: Levels In the Assessment Of Body Compositionmentioning

confidence: 99%

Techniques for the diagnosis of sarcopenia

Rubbieri¹

2014

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SummarySarcopenia is an age-related process of skeletal muscle loss associated with declining physical performance, highly prevalent among older subjects, with a negative prognostic effect on falls, disability and mortality risk. Modern approaches to sarcopenia case finding and diagnosis are based on physical performance measures, while assessment of muscle mass represents the second diagnostic step. Muscle mass can be quantified at different levels of body composition, with a complexity increasing from atomic detection to anatomic measure. In the choice of measuring method, different factors have to be taken into account, including validity, simplicity, cost and specific purpose (clinical versus research). Some methods, such as MRI and CT, have high validity but are complex and costly. Bioelectrical impedance analysis is inexpensive and easy to perform in most settings, being the preferred method for clinical practice. Dual energy X-ray absorptiometry has intermediate cost and complexity with good reproducibility, and is more reliable for research setting. Other methods, such as administration of tritium (D3)-marked creatine and measurement of urinary D3-creatinine, are still in a preclinical phase of development. For all methods the issue of normative data does exist and needs to be solved, in order to reliably identify homogeneous populations with sarcopenia, to be targeted in clinical practice and intervention studies.

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Section: Levels In the Assessment Of Body Compositionmentioning

confidence: 99%

Techniques for the diagnosis of sarcopenia

Rubbieri¹

2014

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“…A meat-free diet was implemented because meat consumption increases urinary 3-methylhistidine values and may falsely represent an increase in myoWbrillar protein turnover (Lukaski et al 1981). Three days of a meat-free diet are required to return 3-methylhistidine levels to baseline (Lukaski et al 1981).…”

Section: Myowbrillar Degradation and Bone Resorptionmentioning

confidence: 99%

Protein supplementation before and after resistance training in older men

et al. 2006

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We determined the effects of protein supplementation immediately before (PRO-B) and after (PRO-A) resistance training (RT; 12 weeks) in older men (59-76 years), and whether this reduces deficits in muscle mass and strength compared to younger men (18-40 years). Older men were randomized to PRO-B (0.3 g/kg protein before RT + placebo after RT, n=9), PRO-A (placebo before + protein after RT, n=10), or PLA (placebo before and after RT, n=10). Lean tissue mass, muscle thickness of the elbow, knee, and ankle flexors and extensors, and leg and bench press strength were measured before and after RT and compared to databases of younger subjects (n=22-60). Myofibrillar protein degradation (3-methylhistidine) and bone resorption (cross-linked N-telopeptides) were also measured before and after RT. Lean tissue mass, muscle thickness (except ankle dorsi flexors), and strength increased with training (P<0.05), with little difference between groups. There were no changes in 3-methylhistidine or cross-linked N-telopeptides. Before RT, all measures were lower in the older compared to younger groups (P<0.05), except for elbow extensor muscle thickness. Following training, muscle thickness of the elbow flexors and ankle dorsi flexors and leg press strength were no longer different than the young, and elbow extensor muscle thickness was greater in the old men (P<0.05). Supplementation with protein before or after training has no effect on muscle mass and strength in older men. RT was sufficient to overcome deficits in muscle size of the elbow flexors and ankle dorsi flexors and leg press strength in older compared to younger men.

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“…Meat sources of protein have been shown to increase 3-MH excretion and falsely represent total protein breakdown values (Kies 1977), and at least 3 days of a meat-free diet are required to return urine concentrations of 3-MH to baseline levels (Lukaski et al 1981). An Accredited Practicing Dietitian (Dietitians Association of Australia) designed 7-day lacto-ovo-vegetarian sample menus for each subject.…”

Section: Urine Collection and 3-methylhistidine Analysismentioning

confidence: 99%

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

2006

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This investigation examined chronic alteration of the acute hormonal response associated with liquid carbohydrate (CHO) and/or essential amino acid (EAA) ingestion on hormonal and muscular adaptations following resistance training. Thirty-two untrained young men performed 12 weeks of resistance training twice a week, consuming ~675 ml of either, a 6% CHO solution, 6 g EAA mixture, combined CHO + EAA supplement or placebo (PLA). Blood samples were obtained pre- and post-exercise (week 0, 4, 8, and 12), for determination of glucose, insulin, and cortisol. 3-Methylhistidine excretion and muscle fibre cross-sectional area (fCSA) were determined pre- and post-training. Post-exercise cortisol increased (P<0.05) during each training phase for PLA. No change was displayed by EAA; CHO and CHO + EAA demonstrated post-exercise decreases (P<0.05). All groups displayed reduced pre-exercise cortisol at week 12 compared to week 0 (P<0.05). Post-exercise insulin concentrations showed no change for PLA; increases were observed for the treatment groups (P<0.05), which remained greater for CHO and CHO + EAA (P<0.001) than PLA. EAA and CHO ingestion attenuated 3-methylhistidine excretion 48 h following the exercise bout. CHO + EAA resulted in a 26% decrease (P<0.01), while PLA displayed a 52% increase (P<0.01). fCSA increased across groups for type I, IIa, and IIb fibres (P<0.05), with CHO + EAA displaying the greatest gains in fCSA relative to PLA (P<0.05). These data indicate that CHO + EAA ingestion enhances muscle anabolism following resistance training to a greater extent than either CHO or EAA consumed independently. The synergistic effect of CHO + EAA ingestion maximises the anabolic response presumably by attenuating the post-exercise rise in protein degradation.

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Relationship between endogenous 3-methylhistidine excretion and body composition

Cited by 47 publications

References 20 publications

Techniques for the diagnosis of sarcopenia

Techniques for the diagnosis of sarcopenia

Protein supplementation before and after resistance training in older men

Independent and combined effects of liquid carbohydrate/essential amino acid ingestion on hormonal and muscular adaptations following resistance training in untrained men

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