Relationship Between E-Cadherin Expression and Lymph-Node Metastasis in Human Esophageal Cancer

Miyata, Mariko; Shiozaki, Hitoshi; Iihara, Keisuke; Shimaya, K; Oka, Hiroyuki; Kadowaki, Tadashi; Inoue, Masahiro; Tamura, Shuji; Takeichi, Masatoshi; Mori, Takahide

doi:10.3892/ijo.4.1.61

Cited by 17 publications

(15 citation statements)

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“…22,23 There is a paucity of information regarding expression of plakoglobin, E-cadherin and b-catenin in Paget's disease of the vulva and, as such, the role of these molecules has not been clearly established in Paget's disease of the vulva. 20,21,24 To our knowledge, only one study has examined the expression of plakoglobin in Paget's disease of the vulva.…”

Section: Plakoglobin Expression In Paget's Disease Of the Vulvamentioning

confidence: 99%

Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast

et al. 2008

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Section: Plakoglobin Expression In Paget's Disease Of the Vulvamentioning

confidence: 99%

Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast

et al. 2008

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“…These observations are supported by in vitro assays where transfection of E-cadherin cDNA into deficient cells reduces invasiveness and tumorigenicity and increases cell adhesiveness and also down-regulates epidermal growth factor receptor (Vleminckx et al, 1991;Miyaki, 1995;Wilding et a!., 1996). Conversely, blocking E-cadherin function in epithelial cells induces an invasive phenotype (Behrens et al, 1989).Positive correlations between reduced E-cadherin expression and increased incidence of lymph node metastases have been reported in various carcinomas, including pancreas, gastric, esophageal, breast, prostate, and head and neck (Matsuura Umbas et al, 1992;Miyata et al, 1994;Pignatelli et al, 1994;Schipper et al, 1994;Yamada et al, 1997). Murine ovarian carcinoma cells which strongly express E-cadherin show low metastatic potential (Hashimoto et al, 1989 (1994) carried out invasion assays using cell lines derived from tongue SCC.…”

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confidence: 99%

Cell Adhesion Molecules and Oral Cancer

Thomas

Speight

2001

Critical Reviews in Oral Biology & Medicine

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Cell adhesion molecules (CAMs) are found on the surfaces of all cells, where they bind to extracellular matrix molecules or to receptors on other cells. As well as having a structural role, CAMs function as signaling receptors, transducing signals initiated by cellular interactions which regulate many diverse processes, including cell division, migration, and differentiation. Cell adhesion molecules are essential for maintaining stable tissue structure. However, cell adhesion must be dynamic to facilitate the mobility and turnover of cells. In dynamic situations, cells alter their cell-cell and cell-matrix interactions by virtue of altered expression and function of CAMs. The expression of CAMs is normally tightly regulated, thereby controlling cell proliferation, mobility, differentiation, and survival. Many of these processes are misregulated in malignant tumors, and it has been shown that many of the characteristics of tumor cells are attributable to the aberrant expression or function of CAMs.Integrins and E-cadherin are the most important CAMs expressed by stratified squamous epithelium. Altered expression of these molecules has been found in oral carcinoma, where loss of CAM expression is often seen in poorly differentiated lesions.However, up-regulation of certain integrins, such as av16, has consistently been found in oral cancer, suggesting that it may play an active role in disease progression.Key words. Oral cancer, cell adhesion molecules, integrins, cadherins, selectins, immunoglobulin superfamily, CD44. (I) IntroductionCell adhesion molecules (CAMs) are found on the surfaces of all cells, where they bind to extracellular matrix molecules or to receptors on other cells. Cell adhesion is critical in the dynamic processes necessary for tissue morphogenesis in development and the maintenance of complex differentiated tissues in adult organisms. CAMs serve in these roles by virtue of their capacity to connect the exterior of the cell with the interior. They form structural linkages between the cell cytoskeleton and the extracellular matrix or between cells, and also function as signaling receptors, transducing signals initiated by cellular interactions which regulate many diverse processes, including cell division, migration, and differentiation ( Fig. 1).Cell adhesion molecules are essential for maintaining the stable structure of stratified squamous epithelium. In normal epithelium, keratinocytes are attached to each other and to the underlying basement membrane. Cell adhesion, however, must be dynamic to facilitate the mobility and turnover of cells. In dynamic situations, keratinocytes alter their cell-cell and cell-ECM interactions by virtue of altered expression and function of CAMs.The expression of cell adhesion molecules is normally tightly regulated-forming, persisting, or declining in an ordered fashion. This allows for controlled cell proliferation, mobility, differentiation, and survival. Many of these processes are misregulated in malignant tumors, and it has been shown that man...

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“…Os trabalhos de Leme et al (21) e Jesus et al (14) são equivalentes quanto à metodologia em relação ao TNM, comparando todos os estádios da doença com a imunoexpressão da proteína caderina-E e não encontrando relação estatística, o que reforça a hipótese de que essa proteína não participa do processo de progressão tumoral.…”

Section: Resumo Dos Resultados Verificados Na Avaliação Da Relação Daunclassified

“…Por outro lado, Kitadai et al (19) não evidenciaram relação estatística da perda da imunoexpressão da caderina-E com metástases hepáticas no carcinoma colorretal, e Leme et al (21) não relacionaram a imunoexpressão da proteína caderina-E com o estadiamento TNM (T: tumor, N: linfonodo, M: metástase) e o prognóstico.…”

Section: Introductionunclassified

Estudo da relação entre a imunoexpressão das proteínas caderina-E e DCC com o grau de diferenciação celular e o estadiamento TNM do adenocarcinoma colorretal

Denadai

Silva

Waitzberg

et al. 2007

J. Bras. Patol. Med. Lab.

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Objetivo: Avaliar a relação de duas proteínas que participam do mecanismo de adesão celular com o grau de diferenciação celular e os estadiamentos TNM (T: tumor, N: linfonodo, M: metástase) I e IV no câncer de cólon e reto. Métodos: Foram estudados cem pacientes (54 homens e 46 mulheres) tratados por adenocarcinoma colorretal, estádios I (44) e IV (56). Os cortes histológicos do tecido tumoral foram examinados por técnica de imuno-histoquímica em relação à imunoexpressão das proteínas caderina-E e delect in colon cancer (DCC), sendo classificados como positivos quando se detectou a imunoexpressão r dessas proteínas em 50% ou mais das células tumorais. Resultados: Para o TNM, imunoexpressão da caderina-E estádio I: positiva em 72,7 % e negativa em 35,7% ; estádio IV: positiva em 64,3% e negativa em 35,7%. Proteína DCC: 43,2% positiva e 56,8% negativa no estádio I, e 50% positiva e 50% negativa no estádio IV. Em relação ao grau de diferenciação celular, imunoexpressão da caderina-E -GI: positiva em 70% e negativa em 30%; GII: positiva em 68,4% e 31,6% negativa; GIII: 63,6% positiva e 36,4% negativa. Imunoexpressão da DCC -GI: 40% positiva e 60% negativa; GII: 46,8% positiva e 53,2% negativa; GIII: 54,5% positiva e 45,5% negativa. Não houve diferença significativa entre os grupos. Conclusão: Os resultados dessa pesquisa permitem concluir que não há relação da imunoexpressão das proteínas caderina-E e DCC com o estadiamento TNM (I e IV) e o grau de diferenciação celular no carcinoma colorretal. abstract resumo

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Relationship Between E-Cadherin Expression and Lymph-Node Metastasis in Human Esophageal Cancer

Cited by 17 publications

References 0 publications

Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast

Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast

Cell Adhesion Molecules and Oral Cancer

Estudo da relação entre a imunoexpressão das proteínas caderina-E e DCC com o grau de diferenciação celular e o estadiamento TNM do adenocarcinoma colorretal

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