Relationship Between Duration of Ischemia and Reactive Hyperemia in a Single Vessel

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

A study with the electromagnetic flowmeter of flow patterns in carotid and femoral arteries of rabbits and dogs

“…We did not make a systematic study of the effect of reactive hyperaemia due to occlusion of an artery, but only examined the carotid and femoral flows in a few cases. They correspond to categories 1 and 3 of Randall & Horvath (1953), and our observations appear to agree with theirs. The change in flow level due to reactive hyperaemia seemed to be related linearly to the A. INOUYE AND H. KOSAKA logarithm of the time elapsed after releasing occlusion (Fig.…”

“…When a contralateral artery had been occluded previously this increase in the rate of flow seemed to be enhanced. These results appear to -coincide with those reported by Randall & Horvath (1953), who considered them as due to reactive hyperaemia. In order to eliminate this effect we have always continued recording until the effect of reactive hyperaemia was over.…”

“…In general, however, the shape of the flow curve was nearly the same in hyperaemia as in the normal animal, the only difference being that the mean flow level was raised in the latter. This can be seen in the records presented by Randall & Horvath (1953), and in those illustrated in Fig. 1.…”

“…Concerning this latter point, Shipley et al (1943) and McDonald (1955) have maintained that negative flow is consistently present in the normal femoral flow and have cast suspicion on the fidelity of electromagnetic flowmeters, because flows recorded by this method (Richardson, Denison & Green, 1952;Randall & Horvath, 1953;Richards & Williams, 1953) failed to show a back-flow component. Inouye et al (1955) have already discussed this problem and demonstrated its fidelity.…”

Haemodynamics of the circle of Willis and the leptomeningeal anastomoses: an electromagnetic flowmeter study of intracranial arterial occlusion in the monkey

“…This fact supports the concept that the filling of an empty, low-resistance vascular bed (or pressure differential) is not the only mechanism responsible for reactive hyperaemia, but vasodilatation resulting from accumulated metabolites due to ischaemia probably plays an important role (Randall and Horvath, 1953). SUMMARY Alterations in blood flow through both internal carotid arteries and the ipsilateral vertebral artery following unilateral occlusion of an intracranial artery or arteries in the monkey have been recorded using three electromagnetic flowmeters applied to each artery.…”