Relationship Between Different Subpopulations of Circulating CD4+ T-lymphocytes and Microvascular Structural Alterations in Humans

Ciuceis, Carolina De; Rossini, Claudia; Airò, Paolo; Scarsi, Mirko; Tincani, Anǵela; Tiberio, Guido Alberto Massimo; Piantoni, Silvia; Porteri, Enzo; Solaini, Leonardo; Duse, Sarah; Semeraro, Francesco; Petroboni, Beatrice; Mori, Luigi; Castellano, Maurizio; Gavazzi, A; Rosei, Claudia Agabiti; Rosei, Enrico Agabiti; Rizzoni, Damiano

doi:10.1093/ajh/hpw102

Cited by 21 publications

(20 citation statements)

References 49 publications

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“…Decrease in Treg could play a role in human hypertension. An inverse correlation was observed between the frequency of circulating CD4 + CD25 High CD127 Low Treg and vascular remodelling evaluated by the media/lumen ratio of small subcutaneous resistance arteries and also retinal arterioles in human essential hypertension (De Ciuceis et al ., ). Altogether, these studies suggest that a loss of Treg contributes to the development of hypertension and end‐organ damage.…”

Section: Role Of Adaptive Immune System In Hypertensionmentioning

confidence: 97%

Role of immune cells in hypertension

Caillon

Paradis

Schiffrin

2018

British J Pharmacology

109

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Inflammatory processes have been shown to play an important role in the mechanisms involved in the pathogenesis of hypertension. Innate and adaptive immune responses participate in BP elevation and end-organ damage. Here, we discuss recent studies focusing on novel inflammatory and immune mechanisms that play roles in BP elevation. Different subpopulations of cells involved in innate and adaptive immune responses, such as dendritic cells, monocytes/macrophages and NK cells, on the one hand, and B and T lymphocytes, on the other, contribute to the vascular and kidney injury in hypertension. Unconventional innate-like T cells such as γδ T cells also participate in hypertensive mechanisms by priming both innate and adaptive immune cells, contributing to trigger vascular inflammation and BP elevation. These cells exert their effects in part via production of various cytokines including pro-inflammatory IFN-γ and IL-17 and anti-inflammatory IL-10. The present review summarizes some of these immune mechanisms that participate in the pathophysiology of hypertension.

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Section: Role Of Adaptive Immune System In Hypertensionmentioning

confidence: 97%

Role of immune cells in hypertension

Caillon

Paradis

Schiffrin

2018

British J Pharmacology

109

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“…Data in human hypertension are scarce, however, an increase in circulating interleukin-17A producing CD4+ T cells and both CD4+ and CD8+ T cells that produce interferon-γ were observed in hypertensive patients compared with normotensive controls [ 13 ]. In addition, inverse correlations were observed between indices of microvascular structure (in subcutaneous small arteries or in retinal arterioles) and circulating Treg lymphocytes [ 14 ]. A direct correlation was observed between the media to lumen ratio of subcutaneous small arteries and circulating Th17 lymphocytes [ 14 ], suggesting that some lymphocyte subpopulations may be related to microvascular remodelling, confirming previous animal data [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, inverse correlations were observed between indices of microvascular structure (in subcutaneous small arteries or in retinal arterioles) and circulating Treg lymphocytes [ 14 ]. A direct correlation was observed between the media to lumen ratio of subcutaneous small arteries and circulating Th17 lymphocytes [ 14 ], suggesting that some lymphocyte subpopulations may be related to microvascular remodelling, confirming previous animal data [ 14 ]. Significant relationships were observed between different subpopulations of circulating CD4+ T lymphocytes and microvascular or systemic oxidative stress in humans [ 15 ]; these data suggest that Treg lymphocytes may be protective against microvascular damage, probably because of their anti-oxidant properties, while Th1-Th17 lymphocytes seem to exert an opposite effect, confirming an involvement of adaptive immune system in microvascular damage [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased circulating T regulatory lymphocytes in obese patients undergoing bariatric surgery

et al. 2018

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ObjectiveIt has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed.Design and methodsWe have investigated 32 severely obese patients undergoing bariatric surgery, as well as 24 normotensive lean subjects and 12 hypertensive lean subjects undergoing an elective surgical intervention. A peripheral blood sample was obtained before surgery for assessment of CD4+ T lymphocyte subpopulations. Lymphocyte phenotype was evaluated by flow cytometry in order to assess T-effector and Treg lymphocytes.ResultsA marked reduction of several Treg subpopulations was observed in obese patients compared with controls, together with an increased in CD4+ effector memory T-effector cells.ConclusionIn severely obese patients, Treg lymphocytes are clearly reduced and CD4+ effector memory cells are increased. It may be hypothesized that they might contribute to the development of marked microvascular alterations previously observed in these patients.

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“…Elucidation of impact of TLR‐Ligand model on Tregs will certainly enhance the aspect of regulation of this important subset of cells in health and disease. Treg lymphocytes may have a protective outlook against microvascular damage, probably because of their anti‐oxidant damage .…”

Section: Discussionmentioning

confidence: 99%

Regulatory T cell subsets in peripheral blood of celiac disease patients and TLR2 expression: correlation with oxidative stress

Kumar

Lal

Bhatnagar

2017

APMIS

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The study was carried out to study expression of Toll like receptors 2 (TLR2), natural/inducible Treg and Interferon-γ alongside oxidative stress and understand their significance in pediatric samples. Influence of oxidative stress on Celiac Disease was analysed by evaluating lipid peroxidation, reduced glutathione, Glutathione peroxidase, etc. A comparison was performed among CD patients, CD patients on gluten free diet (GFD), and healthy controls. Peripheral nTregs exhibited a similar pattern of reduced numbers in CD and GFD cases when compared to healthy controls. On the other hand, inducible Tregs were much lower in GFD patients as compared to CD patients. Expression of TLR2 on iTregs was elevated in CD and GFD, however, expression on nTregs was unaltered in all the three groups. The inflammatory cytokine IFN-γ positive Treg cells were found to be elevated in CD as compared to control group. Oxidative stress was elevated in CD as compared to healthy controls while that in GFD samples was lower in comparison to CD. The levels of LPO, activities of enzymes SOD and Catalase were higher in CD and GFD samples when compared to controls. However, enzyme Glutathione peroxidase and reduced glutathione levels declined in both CD and GFD groups as compared to controls. This report highlights the effect of elevated oxidative stress in CD on reduced traffic of iTregs toward periphery. A strong correlation was observed between the cytokine IFN-γ and TLR2 expression in movement of iTregs in CD patients.

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Relationship Between Different Subpopulations of Circulating CD4+ T-lymphocytes and Microvascular Structural Alterations in Humans

Abstract: Our data suggest that some lymphocyte subpopulations may be related to microvascular remodeling, confirming previous animal data, and opening therapeutic possibilities.

Cited by 21 publications

References 49 publications

Role of immune cells in hypertension

Role of immune cells in hypertension

Decreased circulating T regulatory lymphocytes in obese patients undergoing bariatric surgery

Regulatory T cell subsets in peripheral blood of celiac disease patients and TLR2 expression: correlation with oxidative stress

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