Relationship between detection of hepatitis B virus in saliva and periodontal disease in hepatitis B virus carriers in Japan

Kamimura, Hiroteru; Watanabe, Jun; Sugano, Tomoyuki; Kohisa, Junji; Abé, Hiroyuki; Kamimura, Kenya; Tsuchiya, Atsunori; Takamura, Masaaki; Okoshi, Shogo; Tanabe, Yoshinari; Takagi, Ritsuo; Nonaka, Hirofumi; Terai, Shuji

doi:10.1016/j.jiac.2020.10.028

Cited by 6 publications

(8 citation statements)

References 17 publications

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Section: Resultsmentioning

confidence: 95%

“…This hypothesis is further emphasized by a more recent study by Kamimura et al, who found a strong correlation between occult blood traces in saliva and the presence of viral HBV particles [ 34 ]. This study highlighted how HBV DNA particles were found in saliva samples, particularly of elderly patients diagnosed with periodontitis [ 34 ]. The study further speculates that this may pose an increased risk of horizontal HBV transmission in the family, where the probability of contact with infected saliva is quite elevated [ 34 ].…”

Section: Resultsmentioning

confidence: 95%

“…This study highlighted how HBV DNA particles were found in saliva samples, particularly of elderly patients diagnosed with periodontitis [ 34 ]. The study further speculates that this may pose an increased risk of horizontal HBV transmission in the family, where the probability of contact with infected saliva is quite elevated [ 34 ]. The risk is further enhanced if patients suffer from periodontitis, with an increased gingival bleeding index [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Gheorghe

Bennardo²,

Popescu³

et al. 2022

JPM

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Periodontitis is characterized by low-grade inflammation of the periodontal tissues, the structures that support and connect the teeth to the maxilla and mandible. This inflammation is caused by the accumulation of subgingival bacterial biofilm and gradually leads to the extensive damage of these tissues and the consequent loss of teeth. Hepatitis B is a major global health concern; infection with the hepatitis B virus causes significant inflammation of the liver and the possibility of its gradual evolution to cirrhosis. Hepatitis D, caused by infection with the delta hepatitis virus, is manifest only in patients already infected with the type B virus in a simultaneous (co-infected) or superimposed (superinfected) manner. The dental and periodontal status of patients with hepatitis B/D could exhibit significant changes, increasing the risk of periodontitis onset. Moreover, the progression of liver changes in these patients could be linked to periodontitis; therefore, motivating good oral and periodontal health could result in the prevention and limitation of pathological effects. Given that both types of diseases have a significant inflammatory component, common pro-inflammatory mediators could drive and augment the local inflammation at both a periodontal and hepatic level. This suggests that integrated management of these patients should be proposed, as therapeutical means could deliver an improvement to both periodontal and hepatic statuses. The aim of this review is to gather existing information on the proposed subject and to organize significant data in order to improve scientific accuracy and comprehension on this topic while generating future perspectives for research.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

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Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Gheorghe

Bennardo²,

Popescu³

et al. 2022

JPM

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“…First, it represents a site for transmission, as is exemplified by the frequent oral transmission of Epstein-Barr virus, cytomegalovirus, herpes simplex virus and occasional transmission of hepatitis B virus through saliva, 82 or through occult blood. 83 Second, they can gain access to the bloodstream and mediate systemic conditions such as cardiovascular disease and preeclampsia directly. Finally, they may contribute to periodontal diseases via direct damage, synergistic interactions with the local bacteriome, and/or modulating immunological responses (Figure 1).…”

Section: Virus E S In Peri Odontitis: a Vir Al Pl Aque Hyp Othe S Is?mentioning

confidence: 99%

“…Thus, the importance of investigating the presence of human viruses in the oral cavity is at least threefold. First, it represents a site for transmission, as is exemplified by the frequent oral transmission of Epstein‐Barr virus, cytomegalovirus, herpes simplex virus and occasional transmission of hepatitis B virus through saliva, 82 or through occult blood 83 . Second, they can gain access to the bloodstream and mediate systemic conditions such as cardiovascular disease and preeclampsia directly.…”

Section: Viruses In Periodontitis: a Viral Plaque Hypothesis?mentioning

confidence: 99%

Viruses, periodontitis, and comorbidities

Teles

Collman

Mominkhan

et al. 2022

Periodontology 2000

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Seminal studies published in the 1990s and 2000s explored connections between periodontal diseases and systemic conditions, revealing potential contributions of periodontal diseases in the initiation or worsening of systemic conditions. The resulting field of periodontal medicine led to the publication of studies indicating that periodontal diseases can influence the risk of systemic conditions, including adverse pregnancy outcomes, cardiovascular and respiratory diseases, as well as Alzheimer disease and cancers. In general, these studies hypothesized that the periodontal bacterial insult and/or the associated proinflammatory cascade could contribute to the pathogenesis of these systemic diseases. While investigations of the biological basis of the connections between periodontal diseases and systemic conditions generally emphasized the bacteriome, it is also biologically plausible, under an analogous hypothesis, that other types of organisms may have a similar role. Human viruses would be logical “suspects” in this role, given their ubiquity in the oral cavity, association with periodontal diseases, and ability to elicit strong inflammatory response, compromise immune responses, and synergize with bacteria in favor of a more pathogenic microbial consortium. In this review, the current knowledge of the role of viruses in connecting periodontal diseases and systemic conditions is examined. We will also delve into the mechanistic basis for such connections and highlight the importance of those relationships in the management and treatment of patients.

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Detection of HBsAg by ELISA using MoFeNiS, MoCoFeS, MoNiCoS, and FeCoNiS nanocomposites

Soleimani Sardo,

Shourian

2024

Chem. Pap.

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Relationship between detection of hepatitis B virus in saliva and periodontal disease in hepatitis B virus carriers in Japan

Cited by 6 publications

References 17 publications

Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Oral and Periodontal Implications of Hepatitis Type B and D. Current State of Knowledge and Future Perspectives

Viruses, periodontitis, and comorbidities

Detection of HBsAg by ELISA using MoFeNiS, MoCoFeS, MoNiCoS, and FeCoNiS nanocomposites

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