Relationship between depressive symptoms and quality of life in Nigerian patients with schizophrenia

Akinsulore, Adesanmi; Aloba, Olutayo; Mapayi, Boladale; Oloniniyi, Ibidunni Olapeju; Fatoye, F O; Makanjuola, R. O. A.

doi:10.1007/s00127-014-0838-8

Cited by 29 publications

(20 citation statements)

References 33 publications

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“…The high proportion of the total indirect effect indicated that resilience and depressive symptoms play important roles in the improvement of QOL from hope in patients with schizophrenia. Furthermore, the effect of hope on QOL via depression was significantly greater than the effect of hope on QOL via resilience, which was consistent with the high rate of depression and its serious impact on QOL in patients with schizophrenia [13,45].…”

Section: Discussionsupporting

confidence: 76%

“…DeRosse et al found that depressive symptoms were significantly predictive of QOL as well as cognition in patients with schizophrenia [12]. Even after controlling for negative symptoms in multiple regression analysis, depressive symptoms were also an important independent predictor of all QOL domains [13]. As one of the most prevalent domains of depressive syndrome in patients with schizophrenia, hopelessness is regarded as the most powerful psychological predictors of depression [10,14].…”

Section: Introductionmentioning

confidence: 99%

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Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

et al. 2020

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Background: The underlying mechanism between hope and quality of life is as yet unknown. We aim to examine the potential mediating effect of depression and resilience and the moderated effect of sex in this well-established association. Methods: Two hundred seven patients diagnosed with schizophrenia were administered a questionnaire battery that measured hope, depression, resilience and QOL. A multiple mediation model was used to examine the mediating effect of resilience and depression on the association between hope and QOL. A subgroup analysis was performed and a moderated mediation model was examined to find and test the moderated effect of sex on the mediation model. We used Mplus to perform moderation and mediation analyses so that the mediators and moderator could function together in the same model. Result: Sex was the moderator on the direct path between hope and QOL. The relationship between hope and QOL was mediated by resilience and depression in both sexes. When compared with female patients, the effect of hope on QOL was completely mediated by resilience and depression in males. In female patients, the model was partially mediated, and the direct effect of hope on QOL was significantly negatively correlated with the level of hope. Conclusion: We present a conceptual model containing the mediated effects of resilience and depression and the moderated effect of sex between hope and QOL, which we believe facilitates the understanding of these associations. This model should be useful in the formulation of strategies to improve QOL.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

et al. 2020

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“…In Nigeria, 100 people with schizophrenia were screened for the presence of depression during the course of schizophrenia, and their quality of life was compared based on their depression status. According to this study, depression occurred on 27% of people with schizophrenia and the quality of life of these schizophrenia patients was considerably affected as compared to those who do not have depressive symptoms (7).…”

Section: Introductionmentioning

confidence: 69%

Quality of life of people with schizophrenia compared to controls: A case-control study

Woldemariam

Kahsay

2019

Preprint

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Objective: purpose of this study was to compare the quality of life of people with schizophrenia to healthy controls. Results: the present study demonstrated that respondents with schizophrenia have significantly lower scores in Physical component summary ( U=70.5, z=-8.695, p<..001, r=-.734 ), mental component summary ( U=79.0,z= -8.634 p<.001, r=-.730 ), Physical functioning ( U=310, z-9.553, p<.001, r=-.808 ), Role Physical ( U=419, z=-8.975, p<.001, r=-.759 ), Body pain ( U=1395.5, z=-3.501, p<.001, r=-.296 ), General health ( U=320,z=-7.514, p<.001, r=-.635 ), Vitality ( U=353, z=-7.398, p=.001, r=-.625 ), Social functioning ( U=213.5, z=-9.398, p<.001, r=-.794 ), Role emotion ( U=144.5, z=-985, p<.001, r=-.844 ) and Mental health ( U=178, z=-8.199, p<.001, r=-.693 ) compared with healthy controls. Key words: Quality of life, Schizophrenia, Controls, Case-Control

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“…Previous studies reported that depressive and negative symptoms have a significant impact on the QOL of schizophrenia patients. 10 Furthermore, changing to AOM 300 did not exacerbate the depressive and negative symptoms, EPS, common objects and activities and intrapsychic foundation were improved, which may have helped improve the QOL. Therefore, the results suggest the efficacy of AOM 300 in maintenance treatment for schizophrenia when mental symptoms are stable.…”

Section: Discussionmentioning

confidence: 95%

The effect of switching from oral low-dose aripiprazole to aripiprazole once-monthly 300 mg on the quality of life in three patients with schizophrenia

Suzuki

Hibino

Inoue³

et al. 2017

SAGE Open Medical Case Reports

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Background:Schizophrenia is a chronic disease that requires long-term management with antipsychotics; however, an important barrier to the success of long-term treatment is drug noncompliance, which increases the risk of recurrence and hospitalization. Second-generation long-acting injectable antipsychotics have improved drug adherence, and the pharmacological effects of the drugs, and therefore, have become useful treatment options.Methods:We report on three schizophrenia patients who switched from oral low-dose aripiprazole to aripiprazole once-monthly 300 mg. We examined the efficacy and safety of aripiprazole once-monthly 300 mg, as well as its influence on quality of life, from baseline to 20 weeks after aripiprazole once-monthly 300 mg treatment.Results:Aripiprazole once-monthly 300 mg did not exacerbate the depressive and negative symptoms, and extrapyramidal symptoms were improved, which may have helped improve the quality of life.Conclusion:The results suggest the efficacy of aripiprazole once-monthly 300 mg in maintenance treatment for schizophrenia when mental symptoms are stable.

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Relationship between depressive symptoms and quality of life in Nigerian patients with schizophrenia

Abstract: Depression is a common occurrence during the course of schizophrenia. Depressive and negative symptoms have a significant impact on the QOL of patients with schizophrenia.

Cited by 29 publications

References 33 publications

Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

Quality of life of people with schizophrenia compared to controls: A case-control study

The effect of switching from oral low-dose aripiprazole to aripiprazole once-monthly 300 mg on the quality of life in three patients with schizophrenia

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