Relationship between depression and subclinical left ventricular changes in the general population

Kim, Yong Hyun; Kim, Seong Hwan; Lim, Sang Yup; Cho, Goo Yeong; Baik, Inkyung; Lim, Hong Euy; Na, Jin Oh; Han, Seong Woo; Ko, Young Hoon; Shin, Chol

doi:10.1136/heartjnl-2012-302180

Cited by 33 publications

(37 citation statements)

References 36 publications

(12 reference statements)

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“…To the best of our knowledge, only one previous echocardiographic study11 has assessed the association of current depression symptoms with novel echocardiographic parameters. No study has assessed the impact of anxiety symptoms or repeated measures of anxiety and depression symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, no study has examined the association of anxiety symptoms and subclinical cardiac dysfunction measured by echocardiography or MRI, and only one study has examined depression symptoms in this context 11. Kim et al 11 previously found that early left ventricular (LV) diastolic function was reduced in participants with mild or moderate depression symptoms compared to in participants with no depression symptoms.…”

Section: Introductionmentioning

confidence: 99%

“…Kim et al 11 previously found that early left ventricular (LV) diastolic function was reduced in participants with mild or moderate depression symptoms compared to in participants with no depression symptoms. However, they11 included people with hypertension, diabetes and metabolic syndrome, all which may cause both the presence of subclinical cardiac dysfunction12–14 and depression symptoms 15. Depression is known to have a recurrent nature 15.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study

Gustad

Bjerkeset

Strand³

et al. 2016

Open Heart

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ObjectiveSymptoms of anxiety and depression often co-exist with cardiovascular disease (CVD), yet little is known about the association with left ventricular (LV) subclinical dysfunction. We aimed to study the cross-sectional associations of previous, current and repeated depression or anxiety symptoms, with sensitive indices of LV systolic and diastolic function, based on tissue Doppler (TD) and speckle tracking (ST) imaging methods.MethodsA random selection of 1296 individuals free from known CVD, hypertension and diabetes were examined with echocardiography at baseline of the third Nord-Trøndelag Health Study, (HUNT3, 2006–2008). The primary outcomes were LV diastolic function (e′) and LV systolic function (longitudinal global strain). The primary exposures were self-report on the Hospital Anxiety and Depression Scale (HADS). Associations between outcomes and baseline exposures were available for 1034 (80%), and with previous and repeated exposures for 700 participants who also participated in HUNT2 (1995–1997).ResultsPrevious and repeated depression symptoms, but not current depression, were linearly associated with a reduction in e′. The average sum of two repeated HADS-D scores 10 years apart had the strongest effect on e′ (−8.3%; 95% CI −13.9% to −2.7%) per 5 units. We observed a sex difference between depression symptoms and longitudinal global strain (p for interaction 0.019), where women had a marginal negative effect. Anxiety symptoms, neither previous, current nor repeated were associated with subclinical LV dysfunction.ConclusionsIn a healthy sample, confirmed free of CVD, past and repeated depression symptoms were associated with subclinical LV dysfunction. Thus, depression symptoms might represent a modifiable risk factor for future CVD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study

Gustad

Bjerkeset

Strand³

et al. 2016

Open Heart

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“…Depression might be accompanied by increased left ventricular mass (LVM) regardless of blood pressure (BP) levels. [3][4][5] Specific depressive symptoms can be more predictive of CV diseases than others. [6][7][8] The present preliminary study investigated whether specific clusters of depressive symptoms were associated with increased LVM in older subjects, independently of BP levels and other risk factors.…”

Section: Depressive Symptom Clusters and Optimistic Traits Are Associmentioning

confidence: 97%

Depressive symptom clusters and optimistic traits are associated with left ventricular mass increase in older subjects independently of blood pressure levels and hypertension

Viscogliosi

Chiriac²,

Pellegrini³

et al. 2015

Geriatrics Gerontology Int

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References1 Toba K, Nakai R, Akishita M et al. Vitality index as a useful tool to assess elderly with dementia. Geriatr Gerontol Int 2002; 2: 23-29. 2 Kobayashi K, Hashimoto K, Kato R et al. The aging males' symptoms scale for Japanese men: reliability and applicability of the Japanese version. Int J Impot Res 2008; 20: 544-548. 3 Corona G, Rastrelli G, Vignozzi L, Mannucci E, Maggi M. How to recognize late-onset hypogonadism in men with sexual dysfunction. Asian J Androl 2012; 14: 251-259. 4 Wang C, Nieschlag E, Swerdloff R et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008; 159: 507-514. 5 Buvat J, Maggi M, Guay A, Torres LO. Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment. J Sex Med 2013; 10: 245-284. 6 Wu FC, Tajar A, Beynon JM et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010; 363: 123-135. 7 Matsumoto AM. Andropause. Clinical implications of the decline in serum testosterone level with aging in men.Depression is an independent risk factor for cardiovascular (CV) diseases, comparable in strength with that of traditional risk factors. 1 Older subjects have increased prevalence and poorer control of hypertension. Depression might be accompanied by increased left ventricular mass (LVM) regardless of blood pressure (BP) levels. [3][4][5] Specific depressive symptoms can be more predictive of CV diseases than others. 6-8

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“…There is precedent for this in that Nakatani et al have reported that patients with acute myocardial infarction who harbor a polymorphic variant in the serotonin transporter gene 5-HTT which is associated with depression have an increased incidence of new cardiac events compared to the normal allele [11]. It is also of note the recent human study that showed sub-clinical left ventricular structure and functional changes in patients with depression [12]. What are the plausible biological mechanisms shared by depression and heart failure?…”

mentioning

confidence: 90%

Healing hearts and minds: Can antidepressants repair the heart?

Murphy

2012

Journal of Molecular and Cellular Cardiology

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Relationship between depression and subclinical left ventricular changes in the general population

Cited by 33 publications

References 36 publications

Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study

Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study

Depressive symptom clusters and optimistic traits are associated with left ventricular mass increase in older subjects independently of blood pressure levels and hypertension

Healing hearts and minds: Can antidepressants repair the heart?

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