Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team

Goldstein, Carly M.; Gathright, Emily C.; Garcia, Sarah

doi:10.2147/ppa.s127277

Cited by 92 publications

(66 citation statements)

References 83 publications

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“…It is likely that this is confounding by indication, as all of these conditions are associated with prescribed medications. Conditions that were not associated with higher ADR rates in the study (such as depression and cardiovascular disease) often go unmedicated, and may be associated with increased symptoms of the condition but not with ADR risk [20,21]. However, it is clear that the relative prevalence of ADRs in KSA differs markedly with the province.…”

Section: Discussionmentioning

confidence: 91%

National Cross-Sectional Study of Community-Based Adverse Drug Reactions in Saudi Arabia

Almubark

Aljadani

Alqahtani

et al. 2020

Drugs - Real World Outcomes

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Background An adverse drug reaction (ADR) is a response to a medicine that is not intended and is harmful, and which occurs at normal dose levels for humans. Currently, there are no estimates of the population-based prevalence of ADRs in the Kingdom of Saudi Arabia (KSA). Objective The aims of this study were to (1) estimate the population-based prevalence of ADRs in KSA, (2) describe the ADRs experienced by survey respondents, and (3) investigate the level of awareness of the ADR reporting system. Patients and Methods This was a cross-sectional survey using stratified, population-based sampling conducted at a chain of community pharmacies. Results Analysis was conducted on 5228 surveys; 50.17% of respondents were males, and the mean age was 39 ± 15 years (min = 18, max = 98). The sample prevalence of ADRs was 23.45% (95% CI 22.30-24.60%, P < 0.001). The estimated population prevalence (after weighting) was 28.00% (26.10-30.00%). Gastrointestinal disorders were the most commonly reported ADRs (58.73%), followed by general disorders and administration site conditions (19.74%). The largest drug class that was reported to lead to ADRs was nonsteroidal anti-inflammatory drugs (NSAIDs) (11%). Over 19% of the respondents who experienced an ADR required medical intervention to control the suffering induced by the ADR. Of the respondents who experienced an ADR, 371 (30.26%) were aware of the ADR reporting system but only 53 (14.29%) said that they had filed a report in the system. Conclusions Our study estimated that 28% of the population experienced an ADR over a 1-year period in KSA. Risk factors for ADR included certain chronic disease groups and the use of certain classes of medications. Regulatory authorities in KSA intend to conduct more research and deploy educational interventions to reduce ADR rates in KSA.

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Section: Discussionmentioning

confidence: 91%

National Cross-Sectional Study of Community-Based Adverse Drug Reactions in Saudi Arabia

Almubark

Aljadani

Alqahtani

et al. 2020

Drugs - Real World Outcomes

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“…The disruption of routine clinical practice, the sense of loss of control and the subsequent fear of potential destabilization of the health services, has provoked 'overflowing' anxiety and depression among healthcare professionals, a feature which is not uncommon of epidemics (9,11). Depression is associated with poor medication adherence (12) which may increase morbidity among older healthcare professionals with coexisting medical conditions.…”

Section: Psychological Impact On Healthcare Professionalsmentioning

confidence: 99%

[Comment] COVID-19 pandemic and its impact on mental health of healthcare professionals

et al. 2020

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In light of the unprecedented public health crisis of the COVID-19 pandemic, it is highly important to acknowledge the psychological impact of this mounting threat on healthcare professionals. Previous experience from smaller scale epidemics and emerging literature around COVID-19 show that the unparalleled amount of stress that healthcare workers are dealing with, is associated with increased psychological morbidities. We have depicted the psychological burden that the COVID-19 pandemic has posed on healthcare professionals in Greece and have reviewed the literature around the effect of previous epidemics on frontline healthcare staff. Moreover, we discuss potential triggers and the need for measures to minimise the psychological pressure on those at the frontline against this biothreat.

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“…Many psychological constructs have been examined with respect to health behavior in cases of chronic disease. Mental illness itself, such as depression, has long been linked to non-adherence [49][50][51] and treatment with antidepression medication has been shown to increase adherence with depressed HIV patients. 52 In SPUR, we have avoided examining the impact of mental disorders such as depression, bi-polar or Post-traumatic stress disorder, as they merit specific treatment beyond the type of behavioral support that is the focus of our research.…”

Section: Psychological Factorsmentioning

confidence: 99%

<p>The SPUR Model: A Framework for Considering Patient Behavior</p>

Dolgin¹

2020

PPA

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Background: Medication nonadherence is a global problem that requires urgent attention. Roughly half of all drugs that are prescribed for chronic treatments are not taken by the patients in question. Initiatives designed to support patients and help them modify their behavior are enhanced by personalization, and a number of profiling tools exist to help customize such interventions. Most of these tools were originally designed as paper-based questionnaires, but the growth of digital adherence technologies (DATs) illuminate the need for the development of digital profiling systems that can interact with fully automated patient interfaces. Objective: The objective of this study was to examine existing frameworks from medicine, psychology, sociology, consumer behavior, and economics to elaborate a comprehensive, quantitative profiling approach that can be used to drive the customization of patient support initiatives. Results: Building primarily on Icek Ajzen's Theory of Planned Behavior (TPB), the Health Belief Model (HBM) was used to inform the beliefs about behavior posited in the TPB, while incorporating established factors regarding self-efficacy in the "control" elements of the TPB and selected social and psychological factors in the other constituents of the model. The resulting SPUR (Social, Psychological, Usage, Rational) framework represents a holistic, profiling tool with detailed, quantitative outputs that describe a patient's behavioral risks and the drivers of that risk. Conclusion: An interactive, digital questionnaire built around SPUR represents a potentially useful tool for those desirous of building interactive digital support programs for patients with chronic diseases.

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Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team

Cited by 92 publications

References 83 publications

National Cross-Sectional Study of Community-Based Adverse Drug Reactions in Saudi Arabia

National Cross-Sectional Study of Community-Based Adverse Drug Reactions in Saudi Arabia

[Comment] COVID-19 pandemic and its impact on mental health of healthcare professionals

<p>The SPUR Model: A Framework for Considering Patient Behavior</p>

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