Relationship Between Delayed Reactions to Dermal Fillers and Biofilms

Beer, Kenneth; Avelar, Rui L.

doi:10.1097/01.dss.0000452646.76270.53

Cited by 33 publications

(22 citation statements)

References 26 publications

(22 reference statements)

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“…Biofilms may present as recurrent tender nodules occurring weeks to months after the filler injection . These delayed reactions after dermal filler treatments used to be often attributed to hypersensitivity reactions , however in recent years it has become evident that some of them may form due to bacterial aggregations . The exact mechanisms underlying their development are not yet fully understood.…”

Section: Fillersmentioning

confidence: 99%

Complications associated with cutaneous aesthetic procedures

Hartmann

Ruzicka

Gauglitz

2015

J Deutsche Derma Gesell

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SummaryIn recent years, a plethora of novel therapeutic approaches to fight signs of aging and to influence external body appearance have become available in aesthetic dermatology. Extensive research in this field has led to advanced understanding of the anatomy and physiology of the aging face. To successfully address the complex age-related alterations anti-aging treatment nowadays calls for a multi-faceted approach. Most frequently utilized aesthetic procedures include the use of botulinum toxin, a variety of filling substances, microneedling (collagen induction therapy), chemical peeling, lasers, radiofrequency, thread facelift and injectional lipolysis with phosphatidylcholine/deoxycholate among others. Unfortunately, many clinicians still lack in-depth understanding of potential complications, risk factors and side effects associated with minimal-invasive procedures. The following review aims to give a broad overview of nowadays most frequently used approaches in the dermato-aesthetic field and their related complications.

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Section: Fillersmentioning

confidence: 99%

Complications associated with cutaneous aesthetic procedures

Hartmann

Ruzicka

Gauglitz

2015

J Deutsche Derma Gesell

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“…A biofilm is a complex collection of microorganisms that stimulate the secretion of an extracellular protective and adhesive matrix. Biofilms create circumstances favorable for the development of a microorganism community, which gains further genetic diversity through the superficial attachment of free‐floating cells (Beer & Avelar, ). Complex interactions in the microorganism community continue with the biofilm's augmentation as cells increase in number (Narins, Coleman, & Glogau, ).…”

Section: Discussionmentioning

confidence: 99%

Streptococcus sanguinis isolated from filler granuloma: Successful treatment with incision and drainage

Seok

Jang

et al. 2016

Dermatologic Therapy

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Filler granuloma is considered to be the result of delayed immune responses; growing evidence suggests that they may be secondary to biofilm formation. Dermal filler is technically a foreign body, and as the development of newer generations of dermal fillers lengthens their duration, it is possible that there is also an increased risk of biofilm formation. Here, we present a case report of a patient with Streptococcus sanguinis isolated from a filler granuloma, suggestive of biofilm formation. This case demonstrates the effective use of antibiotics after incision and drainage on antibiotic resistant biofilm.

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“…Prevention or disruption of the EPS, and small molecule signaling pathways are alternative strategies for treatment that are being explored. 2,56 Prevention of biofilm formation may be the next frontier in the management of infections related to implantable devices. As most device-associated infections are likely to originate from implant contamination at the time of implantation, prevention is paramount.…”

Section: Inflammatory and Infectiousmentioning

confidence: 99%

“…As most device-associated infections are likely to originate from implant contamination at the time of implantation, prevention is paramount. 56 Bacteria are the prime source of biofilms. Implant biofilms can be established by colonizing bacteria only at the time of initial injection (although there may be a window of time in which this may occur).…”

Section: Inflammatory and Infectiousmentioning

confidence: 99%

Adverse Reactions to Injectable Fillers

Fitzgerald

Bertucci

Sykes³

et al. 2016

Facial plast Surg

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As the use of fillers becomes increasingly more common and the skill level of those injecting is so varied, adverse events can be expected to increase as well. Avoiding complications is always the best measure, and with appropriate training and injection techniques, many complications can be avoided. However, adverse events can occur in the best of hands, and early detection and treatment may eliminate or minimize sequelae. This article is an effort to help in that endeavor.

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Relationship Between Delayed Reactions to Dermal Fillers and Biofilms

Abstract: Preventative measures may decrease delayed reactions and biofilm formation after injection of dermal fillers. Infection through biofilms should be considered and carefully evaluated to ensure timely treatment.

Cited by 33 publications

References 26 publications

Complications associated with cutaneous aesthetic procedures

Complications associated with cutaneous aesthetic procedures

Streptococcus sanguinis isolated from filler granuloma: Successful treatment with incision and drainage

Adverse Reactions to Injectable Fillers

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