Relationship between Degenerative Disc Disease and Lipid Profiles in Older Adults

Dyslipidemia Is Positively Associated with Chronic Low Back Pain in Korean Women: Korean National Health and Nutrition Examination Survey 2010–2012

“…Yuan et al found that Chinese individuals with high TG ≥ 6.2 mg/dL (OR, 1.775; 95% CI, 1.209, 2.606) and high LDL ≥ 4.1 mmol/L (OR, 1.818; 95% CI, 1.123, 2.943) tended to have a higher risk of developing lumbar intervertebral disc degeneration, a known cause of LBP [ 22 ]. Similarly, a retrospective study of 320 Chinese patients and a case-control study of 105 Koreans by Haung et al found that higher total cholesterol and TG levels were associated with increased lumbar intervertebral disc degeneration and a significantly higher incidence of LBP [ 23 , 24 ]. A case-control study of 269 patients found an increased risk of intervertebral disc degeneration in the setting of dyslipidemia with high TG (OR, 1.753; 95% CI, 1.151, 2.699; p = 0.009), high LDL (OR, 1.952; 95% CI, 1.530, 2.490; p < 0.001), or high total cholesterol (OR, 3.580; 95% CI, 2.182, 55.876; p < 0.001).…”

“…LBP [23,24]. A case-control study of 269 patients found an increased risk of intervertebr disc degeneration in the setting of dyslipidemia with high TG (OR, 1.753; 95% CI, 1.15 2.699; p = 0.009), high LDL (OR, 1.952; 95% CI, 1.530, 2.490; p < 0.001), or high total chole terol (OR, 3.580; 95% CI, 2.182, 55.876; p < 0.001).…”

“…Some studies have found a meaningful association between diabetes and CLBP [ 9 , 17 , 18 , 19 ], whereas others have reported no relationship [ 20 , 21 ]. Similarly, some studies have suggested a positive relationship between dyslipidemia and CLBP [ 10 , 22 , 23 , 24 , 25 ], whereas others have found no association between them [ 23 , 26 , 27 ]. Based on the results of these published studies, the association between CLBP and chronic diseases is still inconsistent.…”