Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid

Falcone, Tommaso; Goldberg, Jeffrey M.; Attaran, Marjan; Sharma, Rakesh K.; Miller, Kathleen B.; Nelson, David R.; Agarwal, Ashok

doi:10.1007/s10815-005-4913-7

Cited by 16 publications

(8 citation statements)

References 34 publications

(34 reference statements)

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“…Using TNF-alpha levels higher than 15 pg/ml in peritoneal fluid (PF), it was possible to discriminate between patients with and without endometriosis with 100% sensitivity and 89% specificity. Using IL-6 levels in serum higher than 2 pg/ml, it was possible to discriminate between patients with and without endometriosis with 90% sensitivity and 67% specificity [42]. In another study, endometriosis could be detected if serum levels of IL-6 were above 1.03 pg/ml with 81% sensitivity, 51% specificity, a positive likelihood ratio of 1.38%, and a negative likelihood ratio of 0.38% [44].…”

Section: Need For a Non-invasive Diagnostic Testmentioning

confidence: 97%

“…No significant difference was found between CA 19-9 and CA 125 in terms of their predictive values for the diagnosis of endometriosis [31]. Moreover, on the basis of the increasing recognition of the role of pleiotropic cytokine IL-6 in the pathophysiology of endometriosis [41], the serum measurement of this protein IL-6 has been proposed in order to discriminate between women with and without the disease [42] and to identify specific forms of the disease [26,43].…”

Section: Need For a Non-invasive Diagnostic Testmentioning

confidence: 99%

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Non-Steroidal Targets in the Diagnosis and Treatment of Endometriosis

Kyama¹,

Mihályi²,

Stella³

et al. 2008

CMC

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Endometriosis, a chronic gynecologic disease frequently resulting in chronic pelvic pain, severe dysmenorrhoea, and subfertility, is defined as the presence of endometrial tissue at extrauterine locations, most commonly on the peritoneum and ovaries. Conclusive diagnosis requires laparoscopic surgery followed by histological confirmation. The treatment options -at present- are limited to hormonal therapies and/or surgical ablation of the lesions, and are characterized by high recurrence rates, significant side-effects and limited duration of administration. The pathogenesis of endometriosis is still unclear and numerous immunological and inflammatory factors have been suggested to be involved in the development of the disease, including interleukin (IL)-1, IL-2, IL-6, IL-8, IL-12, tumour necrosis factor -alpha (TNF-alpha), regulated on activation, normal T-Cell expressed and secreted (RANTES) and its receptor cognate chemokine receptor 1 (CCR1), peroxisome proliferator activated receptors (PPARs), matrix metalloproteinases (MMPs) and cyclooxygenase (COX). Another crucial mechanism in endometriosis is the vascularisation of the endometriotic lesions, with a key role for vascular endothelial growth factor (VEGF). Recently, protease activated receptors (PARs), mitogen-activated protein kinases (MAPKs) and tyrosine kinases have also been associated with the pathophysiology of endometriosis. The aim of this article is to discuss molecules that have recently been found to have connections with the pathogenesis of endometriosis, as potential targets to develop new methods for noninvasive diagnosis and for novel medical management of this disease. This review also critically addresses how these molecules can be tested in basic, preclinical and clinical research, the status of this research and the importance of potential side effects.

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Section: Need For a Non-invasive Diagnostic Testmentioning

confidence: 97%

Section: Need For a Non-invasive Diagnostic Testmentioning

confidence: 99%

Non-Steroidal Targets in the Diagnosis and Treatment of Endometriosis

Kyama¹,

Mihályi²,

Stella³

et al. 2008

CMC

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“…Uterine macrophages and natural killer (NK) cells are a primary source of TNF in the reproductive tract, as well as oviductal epithelial cells of mice and women Bedaiwy et al 2005;Strandell et al 2004). TNF stimulates translocation of the nuclear factor kappa B (NFκB) transcription factors to the nucleus, subsequently triggering transcription of various inflammatory mediators such as IL6 and IL1α (Iwamoto and Konicek 1997;Malinin et al 1997).…”

Section: Tumour Necrosis Factor Alpha (Tnf)mentioning

confidence: 99%

Female Tract Cytokines and Developmental Programming in Embryos

Robertson

Chin

Schjenken

et al. 2015

Advances in Experimental Medicine and Biology

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In the physiological situation, cytokines are pivotal mediators of communication between the maternal tract and the embryo. Compelling evidence shows that cytokines emanating from the oviduct and uterus confer a sophisticated mechanism for 'fine-tuning' of embryo development, influencing a range of cellular events from cell survival and metabolism, through division and differentiation, and potentially exerting long-term impact through epigenetic remodelling. The balance between survival agents, including GM-CSF, CSF1, LIF, HB-EGF and IGFII, against apoptosis-inducing factors such as TNFα, TRAIL and IFNg, influence the course of preimplantation development, causing embryos to develop normally, adapt to varying maternal environments, or in some cases to arrest and undergo demise. Maternal cytokine-mediated pathways help mediate the biological effects of embryo programming, embryo plasticity and adaptation, and maternal tract quality control. Thus maternal cytokines exert influence not only on fertility and pregnancy progression but on the developmental trajectory and health of offspring. Defining a clear understanding of the biology of cytokine networks influencing the embryo is essential to support optimal outcomes in natural and assisted conception.

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“…The chemical composition of the hydrosalpinx fluid is not well known, but tumor necrotic factor-α (TNF-α) is consistently found in the fluid [6]. TNF-α is a multifunctional cytokine derived from the activation of macrophages that can eliminate microorganisms and tumor cells, thus modulating cellular proliferation, differentiation and immunoregulation [7].…”

Section: Introductionmentioning

confidence: 99%

Tumor Necrosis Factor-α, Caspase-9 and Heat Shock Protein 70 Expressions with Leukemia Inhibitory Factor in Hydrosalpinx

Syam

Djuwantono

Effendi

et al. 2020

Preprint

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Background The leakage of hydrosalpinx fluid from the tube into the uterine cavity is likely to interfere with normal implantation. Hydrosalpinx fluids contain tumor necrosis factor-α (TNF-α), which induces caspase-9 signal transduction, leading to apoptosis. Endometrial cells inhibit apoptosis by synthesizing heat shock protein 70 (Hsp70). The TNF-α, caspase-9 and Hsp70 factors are closely related to apoptosis. In women with hydrosalpinx, the endometrial receptivity of embryonic implantation processes is low. Endometrial receptivity can be assessed by leukemia inhibitory factor (LIF). TNF-α, caspase-9 and Hsp70 expression plays an important role in endometrial receptivity disorders in women with hydrosalpinx.Materials and Methods These is an analytic observational, cross-sectional and categorical comparative study was conducted in 44 subjects with and without hydrosalpinx. The present study was performed in Dr. Hasan Sadikin Hospital, Grha Bunda-, Limijati-Maternity and Children Hospital (May-June 2017). Immunohistochemistry was performed with a cutoff based on the ROC. The Mann-Whitney analysis was performed on TNF-α, caspase-9, Hsp70 and LIF in both groups, whereas a correlation regression test was performed to observe the correlation among these protein.Results The present study used the histoscore as a tool to evaluate the expression of variable between study groups. The comparison of the histoscore for parameters between hydrosalpinx and non-hydrosalpinx subjects was TNF-α (12 vs 9; p<0,001), caspase-9 (12 vs 8,5; p<0,001), Hsp70 (6 vs 8; p<0,001), and LIF (9 vs 12; p<0,05), respectively.Conclusion The results showed a significant difference in TNF-α, caspase-9, Hsp70 and LIF (p <0.05) between hydrosalpinx and non-hydrosalpinx patients. Caspase-9 and Hsp70 are inter-connected and related to LIF as a marker in the endometrium receptivity by hydrosalpinx patients.

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Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid

Cited by 16 publications

References 34 publications

Non-Steroidal Targets in the Diagnosis and Treatment of Endometriosis

Non-Steroidal Targets in the Diagnosis and Treatment of Endometriosis

Female Tract Cytokines and Developmental Programming in Embryos

Tumor Necrosis Factor-α, Caspase-9 and Heat Shock Protein 70 Expressions with Leukemia Inhibitory Factor in Hydrosalpinx

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