Relationship between cumulative exposure to metal mixtures and heart rate among Chinese preschoolers

Fu, Ye; Liu, Yun; Li, Yanli; Wang, Yan; Zhu, Meiqin; Lin, Wei; Li, Mingzhu; Liu, Yang; He, Minghui; Yu, Lili; Wang, Jing

doi:10.1016/j.chemosphere.2022.134548

Cited by 16 publications

(10 citation statements)

References 24 publications

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“…ERS derived from the quantification of metal levels in biofluids have been previously used to explore the relationship between metal exposure and disease risk and survival across various health domains, including obesity and its comorbidities, 70 glucose homeostasis, 71 and heart rate regulation. 72 Thus, ERS are a valuable tool for studying multi-pollutant exposures and their impact on disease risk and survival.…”

Section: Discussionmentioning

confidence: 99%

Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Jang,

Dou,

Koubek

et al. 2024

Preprint

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Background: The pathogenesis of amyotrophic lateral sclerosis (ALS) involves both genetic and environmental factors. This study investigates associations between metal measures in plasma and urine, ALS risk and survival, and exposure sources. Methods: Participants with and without ALS from Michigan provided plasma and urine samples for metal measurement via inductively coupled plasma mass spectrometry. Odds and hazard ratios for each metal were computed using risk and survival models. Environmental risk scores (ERS) were created to evaluate the association between exposure mixtures and ALS risk and survival and exposure source. ALS (ALS-PGS) and metal (metal-PGS) polygenic risk scores were constructed from an independent genome-wide association study and relevant literature-selected SNPs. Results: Plasma and urine samples from 454 ALS and 294 control participants were analyzed. Elevated levels of individual metals, including copper, selenium, and zinc, significantly associated with ALS risk and survival. ERS representing metal mixtures strongly associated with ALS risk (plasma, OR=2.95, CI=2.38-3.62, p<0.001; urine, OR=3.10, CI=2.43-3.97, p<0.001) and poorer ALS survival (plasma, HR=1.42, CI=1.24-1.63, p<0.001; urine, HR=1.52, CI=1.31-1.76, p<0.001). Addition of the ALS-PGS or metal-PGS did not alter the significance of metals with ALS risk and survival. Occupations with high potential of metal exposure associated with elevated ERS. Additionally, occupational and non-occupational metal exposures associated with measured plasma and urine metals. Conclusion: Metals in plasma and urine associated with increased ALS risk and reduced survival, independent of genetic risk, and correlated with occupational and non-occupational metal exposures. These data underscore the significance of metal exposure in ALS risk and progression.

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Section: Discussionmentioning

confidence: 99%

Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Jang,

Dou,

Koubek

et al. 2024

Preprint

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“…Metal detection was performed according to the methods described in our previous articles 18,19 and is briefly described hereinafter. We collected children's morning urine samples in uncontaminated containers and stored them at −80°C until further analysis.…”

Section: Methodsmentioning

confidence: 99%

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

et al. 2023

J Occup Environ Med

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Objectives This study aimed to explore the association between multiple metals' exposure and children's height. Methods We collected urine samples and physical measurement data of 1477 preschoolers in China. Children's actual height was measured, and whether reached target height was also assessed. Logistic regression analysis was performed to explore the association between heavy metals and height. The least absolute shrinkage and selection operator regression was used to select the urinary metals, which were highly correlated. Results In the single-metal model after adjusting for potential confounders, urinary iron, aluminum, nickel, chrome, titanium, vanadium, selenium, rubidium, and thallium levels were negatively associated with actual height. Urinary iron, aluminum, nickel, and chrome concentrations were also negatively associated with target height. Conclusions The findings suggested that some urinary metal exposure might be associated with height in preschoolers.

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“…Multivariate Generalized Linear Regression Model (GLM) was used to explore the associations between and maternal TSH and FT4 or neonatal TSH levels and neonatal metabolites with or without adjustment. In GLM models, neonatal metabolite concentrations were standardized to z scores ( 28 ) due to the skewed distributions. To further explore the factors affecting maternal TSH and FT4 and neonatal metabolites, subgroup analysis was performed according to different trimesters of maternal serum sample collection and infant sex.…”

Section: Methodsmentioning

confidence: 99%

Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China

et al. 2022

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AimsNeonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows.MethodsPregnant women were recruited in Jinan Maternity and Child Care Hospital and followed up until delivery. Multivariate generalized linear regression models (GLMs) and restricted cubic spline (RCS) regression analysis models were used to investigate the associations of maternal TSH and FT4 with neonatal metabolites.ResultsIn total, 6,653 pairs of mothers and newborns were enrolled in our study. We identified 5 neonatal metabolites, including arginine/ornithine (Arg/Orn), C14:1/C2, C18:1, C3DC+C4OH and C8:1, that were significantly associated with maternal serum TSH during the whole pregnancy (P < 0.05), especially in the first trimester. Moreover, 10 neonatal metabolites were significantly associated with maternal serum FT4 (P < 0.05), most of which had positive correlations with maternal FT4 in the first trimester (P < 0.05). Some neonatal metabolites also had linear or nonlinear dose-effect relationships with maternal serum TSH and FT4 during the whole pregnancy, particularly in the first trimester.ConclusionsOur study, for the first time, provides epidemiological evidence that maternal serum TSH and FT4, especially during the first trimester, are associated with linear or nonlinear variations in neonatal metabolites. Efforts to identify newborn metabolism levels should carefully consider the effects of maternal thyroid function.

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Relationship between cumulative exposure to metal mixtures and heart rate among Chinese preschoolers

Cited by 16 publications

References 24 publications

Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Metal mixtures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Association Between Heavy Metals Exposure and Height in Chinese Preschoolers

Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China

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