Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea

Abstract

This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) joint cluster and Seoul (RR = 2.29, LLR = 7,602.472), respectively. The MLC for clonorchiasis was in the southeastern part of Korea, while that for CCA was in the southern part. Clonorchiasis showed a decreasing trend in the southeastern districts, while increased in the southwestern districts. Cities in the central region had a decreasing trend, while the western districts had an increasing trend. In most adults (30-59), infection rate of clonorchiasis showed a significant decrease until 2018, while thereafter increased, although not significant. CCA showed a sharply decreasing tendency. The incidence of clonorchiasis and CCA were positively correlated. In general, the correlation was weak (r = 0.39, P < 0.001), but it was strongly positive around the 4 river basins (r = 0.74, P < 0.001). This study might provide an analytic basis for developing an effective system against clonorchiasis and CCA.

Genome-wide identification of histone lysine methyltransferases and their implications in the epigenetic regulation of eggshell formation-related genes in a trematode parasite Clonorchis sinensis

“…The genomes of the helminth species encoded diverse SET-HKMTs, although some entries were not completely predicted (entries marked with asterisks in Table 1). The evolutionary relationships of these SET-HKMT orthologs were examined via phylogenetic analysis based on their SET domain sequences (21,16,18,28,4,14, and 25 proteins from C. sinensis, S. mansoni, E. granulosus, H. microstoma, S. mediterranea, G. pallida, and human, respectively). As shown in Fig.…”

“…The metacercariae excyst in the duodenum and grow into mature adults in the bile ducts. Patients with clonorchiasis exhibit a wide spectrum of clinical symptoms, ranging from obstructive cholangiopathy to cholangiocarcinoma, depending on the rate and duration of infection [ 16 ]. The hepatobiliary worm is categorized as Group I biocarcinogens by the World Health Organization [ 17 ].…”

Editorial: Biopreservation strategies for sustainable food processing

“…Ensuring food safety and quality while reducing the use of hazardous chemical additives has emerged as a pressing priority, driven by discerning consumers who seek clean label products. Simultaneously, the emergence of antibiotic-resistant foodborne pathogens and the recurring foodborne outbreaks have sparked an urgent quest for alternative preservation methods (Kim and Ahn, 2022). Conventional techniques, often comprising thermal and chemical processes, while effective in increasing microbiological food safety, may inadvertently compromise nutritional integrity and organoleptic characteristics of foods (Possas et al, 2018).…”