Relationship between circulating irisin, renal function and body composition in type 2 diabetes

Liu, Jing; Liu, Sylvia; Wong, Melvin D.S.; Tan, Chin Tiong; Tavintharan, Subramaniam; Sum, Chee Fang; Lim, Su Chi

doi:10.1016/j.jdiacomp.2013.09.011

Cited by 95 publications

(85 citation statements)

References 27 publications

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“…Furthermore, in the present study the irisin level was negatively correlated with age, fasting blood glucose, creatinine, and LDL-C, and positively correlated with the GFR, as previously reported (32,33,37,38). In a study that included diabetic patients with CKD multivariate linear regression analysis showed that the GFR was an independent predictor of the irisin level (33). Similarly, in the present study CKD stage was an independent predictor of the irisin level; for every unit increase in CKD stage the irisin level decrease 4.663-fold.…”

Section: Discussionsupporting

confidence: 90%

“…In diabetic CKD patients the irisin level has been shown to decrease as CKD stage increases, based on an evaluation of the association between renal function and the irisin level (33). Similarly, in the present study the irisin level decreased as CKD stage increased in non-diabetic CKD patients.…”

Section: Discussionsupporting

confidence: 74%

“…They posited that the low level of irisin in CKD was due to the inhibitory effect of indoxyl sulphate (32). Liu et al evaluated the association between the irisin level and renal function in patients with type 2 diabetes and reported that patients with a GFR <60 mL/min/1.73 m 2 had a lower irisin level than those with a GFR >60 mL/min/1.73 m 2 , which the researchers thought was due to decreased muscle mass in CKD (33).…”

Section: Discussionmentioning

confidence: 99%

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The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

Ateş¹,

Ozkayar²,

Arikan³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE:Metabolic activity in patients with chronic kidney disease (CKD) is characterized by increased energy expenditure, protein loss, and catabolic processes. Irisin is a recently discovered thermogenic protein that causes energy expenditure. We are in the opinion that the level of irisin may change in patients with CKD and this condition can contribute to the energy expenditure in CKD. The present study aimed to determine the level of serum irisin, in patients with CKD, and the association between CKD stage and the serum irisin level. MATERIAL and METHODS:The study included 90 patients with CKD (stages 2-4) and 32 healthy controls. Routine laboratory tests and measurement of the serum irisin level in all participants were performed. The serum irisin level was measured using the enzyme-linked immunosorbent assay method. RESULTS:The serum irisin level was significantly lower in the patients with CKD than in the control group (p < 0.05). The mean irisin level in the patient group decreased as the severity of CKD increased (stage 2: 22.1±6.3 ng/mL; stage 3: 17.5±3.4 ng/mL; stage 4: 12.9±3.2 ng/mL; p<0.001). There was a positive correlation between the serum irisin level and the glomerular filtration rate (r=0.625, p<0.001). In the regression analysis CKD stage was an independent predictor of the irisin level (β ± SE= -4.663±0.511, p<0.001). CONCLUSION:In the CKD patients the serum irisin level decreased as the severity of disease increased. Accordingly, the catabolic process, which occurs more frequently in the advanced stages of CKD, might also play a role in decreasing the serum irisin level. KEy wORDS:Energy expenditure, Irisin, Chronic kidney disease Öz AMAÇ: Kronik böbrek yetmezliği (KBY) hastaları enerji tüketiminde artış, protein kaybı ve katabolik sürecin ön planda olduğu bir metabolizmaya sahiptirler. İrisin enerji harcamasına neden olan ve son zamanlarda keşfedilen termojenik bir proteindir. Biz KBY hastalarında irisin düzeyinin değişebileceğini ve bu durumun da KBY'deki enerji harcamasına katkıda bulunabileceğini düşünüyoruz. Çalışmada KBY hastalarında serum irisin düzeyini belirlemeyi ve irisin düzeyi ile KBY evresi arasındaki ilişkiyi incelemeyi amaçladık. GEREÇ ve yÖNTEMLER:Çalışmaya 90 KBY hastası (evre 2 -4) ve 32 sağlıklı kontrol dahil edildi. Katılımcıların rutin laboratuvar parametreleri ve serum irisin düzeyleri çalışıldı. Serum irisin düzeyi ELIZA kiti ile çalışıldı.BULGULAR: Serum irisin düzeyi tüm kronik böbrek hastalığı grubunda kontrol grubuna kıyasla daha düşük saptandı (p<0,05). Kronik böbrek hastalığında hastalık evresi arttıkça ortalama serum irisin düzeyinin azaldığı görüldü (evre 2:22,1±6,3; evre 3: 17,5±3,4; evre 4: 12,9±3,2; p<0,001). İrisin düzeyi ile glomerüler filtrasyon hızı arasında (r:0,625, p<0,001) pozitif yönde bir korelasyon saptandı. Regresyon analizinde KBY evresi irisin düzeyi için bağımsız prediktör olarak saptandı (β±SE= -4,663±0,511, p<0,001). SONUÇ:Kronik böbrek hastalığında hastalık evresi arttıkça serum irisin düzeyinin azalma saptandı. Bu sonuç, ile...

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

Ateş¹,

Ozkayar²,

Arikan³

et al. 2017

Turk Neph Dial Transpl

View full text Add to dashboard Cite

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“…Th e association between T2DM and iris levels is oft en being questioned in recent studies. Studies have shown that irisin levels were lower in the T2DM patients compared to the control ones (Choi et al 2013;Moreno-Navarrete et al 2013;Liu et al 2014). In studies conducted with patients with insulin resistance, irisin levels were determined to increase with the insulin resistance and decrease as insulin sensitivity increases (Sesti et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Factors associated with increased irisin levels in the type 1 diabetes mellitus

Ateş

Arikan

Erdoğan

et al. 2017

Endocrine Regulations

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Objective. Th e aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the infl ammation and autoimmunity.Methods. Th is study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient fi les. Serum irisin levels were measured by ELISA kit.Results. Th e median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels.Conclusion. In patients with T1DM, which chronic infl ammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. Th is may suggest that factors such as infl ammation and autoimmunity can be eff ective in the synthesis of irisin.

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“…As determined in various studies, serum irisin levels decrease in type 2 diabetes mellitus (DM) and gestational DM, non-alcoholic hepatic failure and in individuals with lower body mass indices vs. obese individuals and increase in metabolic syndrome (14,(20)(21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Irisin and Visfatin in Experimental Testicular Torsion

Saraç¹,

Yeniocak²,

Sarsu³

et al. 2018

Haseki

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Aim: Testicular torsion (TT) is one of the most important causes of acute scrotum in children and young men. Very scarce number of serum laboratory parameters might be used in the early diagnosis of patients with TT. We planned this study in consideration of the possible significance of the changes in serum irisin and visfatin levels in the diagnosis of TT. Methods:We used 28 rats in four groups. In the control group, blood samples and specimens of testicular tissue were collected at 2 nd and 4 th hours after torsion. In the torsion groups, the left testis was twisted, and blood samples and specimens of the testicular tissue were collected at the 2 nd and 4 th hours for analysis.Results: There was no statistically significant difference in mean irisin and visfatin levels at the 2 nd and 4 th hours between rats with TT and controls. There was no statistically difference between mean irisin and vistatin levels at the 2 nd hour and at the 4 th hour in torsion and control groups. Conclusion:In our experimental TT method, we could not find a statistically significant difference between serum levels of irisin and visfatin. We assume that further studies are needed on this issue. Keywords: Testicular torsion, experimental, irisin, visfatinAmaç: Testis torsiyonu (TT) çocuklar ve genç erkeklerdeki akut skrotumun en önemli nedenlerinden biridir. TT'li hastalarda erken tanıda kullanılabilecek serum laboratuvar parametreleri oldukça sınırlıdır. Biz de bu çalışmamızı, TT tanısında irisin ve visfatin'in serum düzeylerindeki değişimin anlamlı olabileceğini düşünerek planladık.Yöntemler: Çalışmamızda dört grupta 28 sıçan kullanıldı. Kontrol gruplarında gubernakulum ortaya konduktan sonra 2. ve 4. saatlerde kan ve testis dokuları alındı. Torsiyon gruplarında ise sol testise torsiyon uygulandıktan sonra 2. ve 4. saatlerde kan ve testis dokuları inceleme için alındı. Bulgular: TT olan ratlarda 2. ve 4. saat irisin ve visfatin değerlerinin ortalamalarında kontrol grubuna göre anlamlı fark saptanmadı. Torsiyon grubu ve kontrol gruplarının 4. saatteki irisin ve visfatin ortalamaları ile 2. saat ortalamaları arasında da istatistiksel olarak anlamlı fark saptanmadı. Sonuç:Oluşturduğumuz deneysel TT modelinde, irisin ve visfatinin serum düzeylerinde istatistiksel olarak anlamlı fark bulamadık. Bu konuda ek çalışmalara ihtiyaç olduğunu düşünmekteyiz.

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Relationship between circulating irisin, renal function and body composition in type 2 diabetes

Cited by 95 publications

References 27 publications

The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

The Serum Irisin Level in Non-Diabetic Patients with Chronic Kidney Disease

Factors associated with increased irisin levels in the type 1 diabetes mellitus

The Diagnostic Value of Irisin and Visfatin in Experimental Testicular Torsion

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