Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies

Leng, Lina; Xing, Yingbin; Liang, Yi; Wang, Chang; Ma, Huijuan

doi:10.1016/j.ghir.2021.101416

Cited by 2 publications

(3 citation statements)

References 45 publications

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“…Supporting its WM protective effect, a recent study involving more than 369,000 participants from the UK biobank has revealed that higher concentrations of circulating IGF-1 are associated with greater WM volumes and smaller WMH [109]. In addition to its function as a neurotrophic factor, IGF-1 also regulates vascular remodeling [110], indicating its potential contribution to the retention and improvement of cerebral blood flow [111,112]. Therefore, maintaining IGF-1 levels by PE can also benefit CNS myelination via the first two mechanisms referenced above.…”

Section: Therapeutic Potential Of Physical Exercise On White Matter D...mentioning

confidence: 99%

Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline

Butt,

Tobiume,

et al. 2024

Aging and disease

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In the central nervous system, oligodendrocytes wrap around neuronal axons to form myelin, an insulating layer or sheath that allows for the efficient conductance of action potentials. In addition to structural insulation, myelin provides encased axons with nutrient, metabolic and defensive support. Demyelination, or myelin loss, can therefore cause axonal dysfunction, leading to neurological impairment and disease. In Alzheimer's disease (AD), progressive white matter demyelination is acknowledged as one of the earliest pathologies preceding symptom onset. Unfortunately, current pharmacotherapy for slowing demyelination or promoting remyelination in AD is nonexistent. Exercise is recognized for its wide-ranging benefits to human health, including improved mental health and the prevention of lifestyle-related diseases. Mounting evidence suggests the contribution of physical activity in delaying the progression of dementia in elderly populations. Recent mechanistic studies have shown that exercise facilitates myelination in the brain through the vitalization of intrinsic pro-myelination cues, such as increased neurotrophic factors and electrical activity. In this review, we summarize and discuss the potential of physical exercise on counteracting aging-associated white matter demyelination, which causes cognitive decline in AD. We highlight the need of further basic and clinical research investigations on this topic to establish novel approaches for healthy and improved brain aging.

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Section: Therapeutic Potential Of Physical Exercise On White Matter D...mentioning

confidence: 99%

Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline

Butt,

Tobiume,

et al. 2024

Aging and disease

View full text Add to dashboard Cite

show abstract

“…As an endogenous hormone, IGF-1 is essential for brain development, cognitive function, energy metabolism, and wound healing [ 1 , 2 , 3 , 4 , 5 , 6 ]. In addition to its function as a neurotrophic factor in brain, IGF-1 regulates cerebral and systemic vascular remodelling and function [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The growth hormone (GH) controls the liver production of IGF-1 [ 9 ], which declines with ageing to a very low measurable level in people over 60 years of age [ 9 , 10 ]. An age-related deficiency in IGF-1 production and function can contribute to cardiovascular aging [ 11 ], as well as cerebrovascular diseases such as stroke [ 5 , 12 , 13 ], hypertension [ 6 , 14 ], and cognitive impairment [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions

Guan

Kang

et al. 2023

Molecules

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Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions. The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. Cyclic glycine-proline (cGP), a metabolite from the binding site of IGF-1, retains its affinity for IGFBP-3 and competes against IGF-1 for IGFBP-3 binding. Thus, cGP and IGFBP-3 collectively regulate the bioavailability of IGF-1. The molar ratio of cGP/IGF-1 represents the amount of bioavailable and functional IGF-1 in circulation. The cGP/IGF-1 molar ratio is low in patients with age-related conditions, including hypertension, stroke, and neurological disorders with cognitive impairment. Stroke patients with a higher cGP/IGF-1 molar ratio have more favourable clinical outcomes. The elderly with more cGP have better memory retention. An increase in the cGP/IGF-1 molar ratio with age is associated with normal cognition, whereas a decrease in this ratio with age is associated with dementia in Parkinson disease. In addition, cGP administration reduces systolic blood pressure, improves memory, and aids in stroke recovery. These clinical and experimental observations demonstrate the role of cGP in regulating IGF-1 function and its potential clinical applications in age-related brain diseases as a plasma biomarker for—and an intervention to improve—IGF-1 function.

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Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies

Cited by 2 publications

References 45 publications

Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline

Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline

Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions

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