Relationship Between Circulating Adipokines and Insulin Resistance During Pregnancy and Postpartum in Women with Gestational Diabetes

Saucedo, Renata; Zárate, Arturo; Basurto, Lourdes; Hernández, Marcelino; Puello, Edgardo; Galván, Rosa; Campos, Sandra

doi:10.1016/j.arcmed.2011.06.009

Cited by 64 publications

(71 citation statements)

References 25 publications

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“…While some authors report increased TNF-A levels in GDM, [16][17][18][19][20][21][22] others do not confirm this association. [23][24][25][26][27][28] Similar controversies also exist regarding IL-10, with study showing lower levels of this anti-inflammatory cytokine in patients with GDM 29 whereas others do not confirm these findings. 23,25,27 The observed controversies could be related to differences in the characteristics of the participants, including gestational age and severity of the disease, to different types of sample (serum, plasma or culture supernatant), to the use of different assay methods to measure the concentration of cytokines (i.e., ELISA, chemiluminescent immunoassay or immunoradiometric assay), and also to the lack of adjustment for maternal body mass index (BMI) as well as other important factors such as smoking and ethnicity that affect the production of cytokines.…”

Section: Introductionmentioning

confidence: 79%

“…Twenty of the studies (90.9%) provided information on the participants′ BMI, seven informed their ethnicity, 19,23,25,27,42,43,46 and seven informed their smoking status. 16,18,23,24,29,42,46 Most of the studies were judged to be of moderate or high quality in all domains assessed. The worse domain was quality of results: almost one-third of the studies provided no information on sample size calculation and/or power and did not adjust their results for potential confounders/effect modifiers ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…After screening titles and abstracts, 31 references were selected for full-text reading [16][17][18][19][20][21][22][23][24][25][26][27][28][29][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] and 23 citations reporting on 22 studies were included in this review (Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

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Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

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CitationGomes CP, Torloni MR, Gueuvoghlanian-Silva BY, Alexandre SM, Mattar R, Daher S. Cytokine levels in gestational diabetes mellitus: a systematic review of the literature. Am J Reprod Immunol 2013; 69: 545-557 doi:10.1111/aji.12088 Problem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of StudyThree electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. ResultsTwenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD = 0.45, 95% CI À0.34-1.23). ConclusionsNew studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.

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Section: Introductionmentioning

confidence: 79%

Section: Resultsmentioning

confidence: 99%

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Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gomes

Torloni

Gueuvoghlanian-Silva

et al. 2013

American J Rep Immunol

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“…Saucedo et al (2011) analyzed the insulin resistance (HOMA-IR), serum insulin of fasting and RBP-4 during pregnancy (30th week) and in the postpartum period (6th week) and verified that the insulin levels and RBP-4 decreased significantly after childbirth in healthy women, strengthening the hypothesis of the influence of placental hormones during healthy pregnancy, however, no significant change for women with diabetes was found.…”

Section: Discussionmentioning

confidence: 96%

Gestational diabetes: a risk of puerperal hypovitaminosis A?

Resende

Lira

Grilo

et al. 2015

An. Acad. Bras. Ciênc.

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The influence of gestational diabetes on vitamin A deficiency in lactating women and, consequently, in their newborn has been verified through a cross-sectional case-control study conducted with volunteer puerperal women. The control group consisted of healthy women and the test group was composed of women with gestational diabetes. One hundred and seven women were recruited, corresponding to 71 controls and 36 cases. Personal, gestational and newborn data were collected directly from medical records during hospitalization. The retinol was determined in maternal colostrum and serum by High Performance Liquid Chromatography. Postpartum women with gestational diabetes were older, had more children and a higher prevalence of cesarean delivery. No difference was found in retinol concentration in maternal milk and serum between the groups. However, it was observed that 16.7% had vitamin A deficiency in the group of patients with diabetes and only 4.1% had such deficiency in the control group. Although no difference was found in colostrum and serum retinol concentration between women with and without gestational diabetes, the individual analysis shows that those with diabetes are at higher risk of being vitamin A deficient.

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“…12,16,[17][18][19] These above-mentioned studies could not find the correlation between serum adiponectin and GDM thus questioning the predictive nature of serum adipokines. Other cytokines TNFα the inflammatory mediators also show no correlation with the GDM subjects as in our study, which contradicts the result of the study done by Kautzky et al who explained by his study that increased leptin levels in GDM increases insulin resistance by increasing TNFα and IL-6.…”

mentioning

confidence: 99%

Correlation of serum biomarkers in prediction of gestational diabetes mellitus

Menon¹,

Alaganandha²,

Mohan³

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Adiponectin and Leptin are adipokines produced by adipocytes. TNF-alpha and IL-6 are inflammatory cytokines which increases insulin resistance. Decreased adiponectin, increased leptin, TNF-alpha and IL-6 is associated with risk of Gestational Diabetes Mellitus, characterised by glucose intolerance that begins or first recognised in pregnancy leading to maternal and foetal complications. India has a high prevalence of GDM upto 16.55% by (2hr plasma glucose of more than 140mg/dl). We aimed to evaluate whether ‘First trimester serum biomarkers predict gestational diabetes mellitus’. The objective of the study was to study the serum biomarkers levels in early pregnancy and predict the risk of developing gestational diabetes mellitus. To study the correlation of serum biomarkers levels in gestational diabetes mellitus.Methods: The study was conducted between October 2014 to March 2016 in healthy pregnant women aged 20-35 yrs attending the antenatal OPD in ESIC Hospital. Study design: Prospective observational study with three study groups 1. NGT, 2. GDM1, 3. GDM2 with two-time points one at first trimester and other second trimester. Sample size: 125 pregnant women. Work plan: Demographics, baseline characteristics and other clinical risk factors of pregnant women in 1st trimester who consented for the study, meeting the inclusion criteria are noted. 75 gm OGCT (oral glucose challenge test) done at two-time points first and second trimester in the study groups will be analysed using the DIPSI criteria with a cut-off value ≥140mg/dl and divided into 3 groups. Serum biomarkers were measured by DRG ELISA method at one-time point in first trimester in all the 3 groups.Results: The serum levels of adiponectin are comparatively reduced in first trimester GDM1 group. As the difference was not significant with p-value of 0.33 there was no correlation between adiponectin and GDM in our study. Serum leptin is increased in second trimester GDM group but the difference is insignificant with a p value of 0.11 showing no correlation.Conclusions: Among the cytokines IL-6 also shows an increasing tendency in both GDM1 (5.9±0.57) and GDM2 (6.04±1.04) groups compared to the NGT (5.82±0.38) group. Serum TNFα is increased in GDM1 (17.29±17.14) and NGT (17.03±24.03) compared to GDM2 (13.54±17.29) group.

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Relationship Between Circulating Adipokines and Insulin Resistance During Pregnancy and Postpartum in Women with Gestational Diabetes

Cited by 64 publications

References 25 publications

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

Gestational diabetes: a risk of puerperal hypovitaminosis A?

Correlation of serum biomarkers in prediction of gestational diabetes mellitus

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