Relationship between ciprofloxacin resistance and extended-spectrum β-lactamase production in Escherichia coli and Klebsiella pneumoniae strains

Abstract

Resistance to fluoroquinolones has increased markedly since their introduction. Mechanisms of resistance to any antibiotic class might play a role in resistance to an unrelated antibiotic class. This study evaluated the relationship between extended-spectrum beta-lactamase (ESBL) production and ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae strains isolated as causative agents of urinary tract infection. ESBL-producing strains were significantly more frequent among ciprofloxacin-resistant E. coli strains than among ciprofloxacin-susceptible E. coli strains (p = 0.015), but the difference was not significant among K. pneumoniae strains (p = 0.276).

Molecular Epidemiological Analysis of Escherichia coli Isolates Producing Extended-Spectrum β-Lactamases for Identification of Nosocomial Outbreaks in Stockholm, Sweden

“…The ESBL-producing strains, in the present study, were coresistant to ciprofloxacin, which was in accordance to the report by Tolun et al (18). The study by Paterson et al (13) showed that 11 of the 15 ciprofloxacin-resistant ESBL-producing Klebsiella pneumoniae isolates belonged to just four genotypes, similarly 15 of the 18 ciprofloxacin-resistant ESBL-producing E. coli isolates in the present study were grouped into only two clones, suggesting that patient-to-patient transmission of such strains occurred.…”

Dramatic Increase in Prevalence of Fecal Carriage of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae during Nonoutbreak Situations in Spain

“…Fluoroquinolone resistance is becoming a common feature rather than an exception in ESBL-producing isolates (43,37,46,39). In our study, the decrease in the rate of fluoroquinolone susceptibility was high both in the community (62.5%) and in the hospital (41.6%) isolates recovered from patients during 2003 (Table 3).…”

Prévalence des souches d’entérobactéries productrices de bêta-lactamases à spectre élargi isolées au Togo et de leur sensibilité aux antibiotiques

“…Klebsiella spp a aussi affiché une résistance de 4,23% à 94,64% aux aminosides, 75% à 95,83% aux quinolones. Ces observations corroborent les travaux de Tolun et al (2004). Selon certains auteurs, le plasmide qui porte le gène de résistance aux bêta-lactamines porterait également le gène QnrA de résistance aux quinolones (Bradford, 2001 ;Paterson et Bonomo, 2005); ce fait expliquerait bien mieux la multirésistance de certaines souches EBLSE.…”