Relationship between chronobiological thyrotropin and prolactin responses to protirelin (TRH) and suicidal behavior in depressed patients

Duval, Fabrice; Mokrani, Marie‐Claude; Erb, Alexis; opera, Felix Gonzalez; Calleja, Cécile; Paris, Veronique

doi:10.1016/j.psyneuen.2017.07.488

Cited by 29 publications

(22 citation statements)

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“…Consistent with a previous study, ΔΔTSH values are reduced in depressed SADs and BDs, while they are unaltered in SCHs ( 9 ). We have already discussed that the ΔΔTSH test is a chronobiological refinement of the TRH test ( 25 , 44 ). Pathophysiological components involved in an abnormal ΔΔTSH test may be synthesized as follows ( 21 ):…”

Section: Discussionmentioning

confidence: 99%

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Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

et al. 2020

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Background: This study aimed to assess hypothalamic-pituitary dopaminergic (DA), noradrenergic (NA), thyroid (HPT), and adrenal (HPA) activity in schizophrenia, in schizoaffective disorder, and in bipolar disorder. Method: We investigated a combined approach of hormone responses to (1) apomorphine (APO), a short-acting DA receptor agonist which decreases prolactin secretion (PRL), and stimulates secretion of growth hormone (GH), adrenocorticotropin (ACTH), and cortisol; (2) clonidine (CLO), an alpha 2-adrenoceptor agonist which stimulates GH secretion; (3) 8 AM and 11 PM protirelin (TRH) which stimulates thyrotropin (TSH) secretion; and (4) dexamethasone which suppresses cortisol secretion, in 13 hospitalized healthy male controls and 39 untreated male inpatients: 13 with DSM-IV paranoid schizophrenia, 13 with DSM-IV schizoaffective disorder (bipolar subtype, depressed at the time of the study), and 13 with DSM-IV bipolar disorder (depressed). Results: Compared to controls, paranoid schizophrenic patients showed (1) lower APOinduced ACTH and cortisol stimulation, and (2) higher post-dexamethasone cortisol values. Compared to controls, schizoaffective and bipolar patients showed (1) lower DDTSH values (i.e., difference between 11 PM and 8 AM TRH-TSH responses), (2) lower APO-induced PRL suppression, (3) lower CLO-induced GH stimulation, and (4) higher post-dexamethasone cortisol values. Conclusions: Although results must be interpreted with caution because of the small sample, this preliminary study suggests that depressed bipolar and schizoaffective patients share common biological dysregulations, distinct from that of paranoid schizophrenic patients. From a pathophysiological viewpoint, paranoid schizophrenic patients can be characterized by hyposensitivity of the hypothalamic DA receptors (possibly resulting from an increase in presynaptic DA release) associated with increased HPA axis activity, while depressed bipolar and schizoaffective patients can be characterized by hyposensitivity of the pituitary TRH and DAD 2 receptors (possibly linked

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Section: Discussionmentioning

confidence: 99%

“…A self-regulating component, since the ΔΔTSH test takes into account the negative feedback of thyroid hormones on TSH secretion. Indeed, the TRH test performed at 8 AM stimulates thyroid hormone secretion, increasing, therefore, the negative feedback of thyroid hormones on TSH secretion in the evening ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

et al. 2020

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“…36 Thus, a deficit in central TRH function in suicide attempters could result in an impaired TSH resynthesise, explaining why FT4 18 and FT3 are decreased. 37,38 Previous studies have explored the relationship at group level between depressive symptom severity and SI among MDD. Consistent with previous studies, the severity of depressive symptoms has a robust association with SI.…”

Section: Risk Factors Of Si Among Mddmentioning

confidence: 99%

Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China

Ge¹,

Jiang²,

Wang³

et al. 2020

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These authors contributed equally to this work Background: A growing body of research suggests that major depressive disorder (MDD) is one of the most common psychiatric conditions associated with suicide ideation (SI). However, how a combination of easily accessible variables built a utility clinically model to estimate the probability of an individual patient with SI via machine learning is limited. Methods: We used the electronic medical record database from a hospital located in western China. A total of 1916 Chinese patients with MDD were included. Easily accessible data (demographic, clinical, and biological variables) were collected at admission (on the first day of admission) and were used to distinguish SI with MDD from non-SI using a machine learning algorithm (neural network). Results: The neural network algorithm distinguished 1356 out of 1916 patients translating into 70.08% accuracy (70.68% sensitivity and 67.09% specificity) and an area under the curve (AUC) of 0.76. The most relevant predictor variables in identifying SI from non-SI included free thyroxine (FT4), the total scores of Hamilton Depression Scale (HAMD), vocational status, and free triiodothyronine (FT3). Conclusion: Risk for SI among patients with MDD can be identified at an individual subject level by integrating demographic, clinical, and biological variables as possible as early during hospitalization (at admission).

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“…10 The master clock regulates the endogenous rhythm in response to environmental inputs and dysfunction of the master clock could contribute to a wide range of illnesses including obesity, diabetes mellitus, autoimmune disorders, and particularly mental disorders. [40][41][42][43][44] Disruption that arises due to a misalignment between inner physiology and the external world or a clock gene polymorphism may facilitate the emergence of diseases, increased disease severity and worsened prognosis, and heightened risk for poor treatment outcomes. 45,46 Clock genes, their main functions and association with psychiatric disorders summarized in Table 1.…”

Section: Involvement Of Master Clock In the Regulation Of Circadian Rmentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2020

Psychiatry Investig

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Objective Several lines of evidence support a relationship between circadian rhythms disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities.Methods The Medline, Embase, PsycInfo, and Scopus databases were comprehensively and systematically searched and articles published between January 1990 and October 2019 were reviewed. Different combinations of the relevant keywords were polled. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders.Results Although subject characteristics and study designs vary across studies, current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. Impaired HPA-axis function-related glucocorticoid rhythm and disrupted melatonin homeostasis have been prominently demonstrated in schizophrenia and other psychotic disorders, while alterations of molecular expressions of circadian rhythm genes including CLOCK, PER, and CRY have been reported to be involved in the pathogenesis of mood disorders.Conclusion Further translational work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders and related psychopathology, and to develop sound pharmacologic interventions.

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Relationship between chronobiological thyrotropin and prolactin responses to protirelin (TRH) and suicidal behavior in depressed patients

Cited by 29 publications

References 59 publications

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

Dopaminergic, Noradrenergic, Adrenal, and Thyroid Abnormalities in Psychotic and Affective Disorders

<p>Identifying Suicidal Ideation Among Chinese Patients with Major Depressive Disorder: Evidence from a Real-World Hospital-Based Study in China</p>

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

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