Relationship Between Choroidal Thickness and Choroidal Circulation in Healthy Young Subjects

Sogawa, Kenji; Nagaoka, Taiji; Takahashi, Atsushi; Tanano, Ichiro; Tani, Tomofumi; Ishibazawa, Akihiro; Yoshida, Akitoshi

doi:10.1016/j.ajo.2011.11.005

Cited by 115 publications

(75 citation statements)

References 21 publications

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“…In addition, the subfoveal choroidal thickness decreased only by 15.6 mm for each decade of life, 16 indicating that the choroidal thickness change caused by age is not significant compared with diopter and ODI. Consistent with the results of Sogawa et al, 19 increased choroidal thickness was associated with increased diopter. The subfoveal choroidal thickness was significantly thinner in the severe group after correcting for the diopter, and the degree was associated with ODI, indicating that the degree of thinning of the choroid is associated with fluctuation in the frequency of SaO 2 .…”

Section: Eyesupporting

confidence: 82%

“…[16][17][18] In the Chinese population, the subfoveal choroidal thickness is not correlated with age in subjects younger than 60 years, whereas the subfoveal choroidal thickness is relatively thinner and significantly negatively correlated with age in the population older than 60 years. 18 Meanwhile, the choroidal thickness was shown to increase along with the severity of the diopter, 19 and a pattern of diurnal variation exists. 20 Therefore, we carried out all of the choroidal and retinal Retinal and choroidal thickness evaluation by SD-OCT C Xin et al…”

Section: Discussionmentioning

confidence: 99%

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Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

Chen

Wang

Zhang

et al. 2014

Eye

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Objective To assess the macular retina and choroidal thickness change in patients with obstructive sleep apnea-hypopnea syndrome (OSAS) with no significant symptoms and pathological changes in the fundus using spectral domain-optical coherence tomography. Methods This prospective, observational case-control study consisted of 53 eyes of 53 patients with OSAS and 12 eyes of 12 age-matched controls. Macular and choroidal thicknesses were measured by optical coherence tomography. Results The foveal and nasal macular thicknesses were significantly different between four groups (P ¼ 0.001, P ¼ 0.016). The foveal thickness of the control group was significantly thinner than that of the severe group (P ¼ 0.000). The nasal macular thickness of the control group was significantly thinner than that of the severe group (P ¼ 0.008). A significant correlation was found between oxygen desaturation index (ODI) and macular center thickness (r ¼ 0.357, R 2 ¼ 0.127, P ¼ 0.004), with an ODI coefficient of 0.457 (P ¼ 0.004). Similarly, a significant correlation was found between ODI and nasal macular thickness (r ¼ 0.265, R 2 ¼ 0.070, P ¼ 0.033), with an ODI coefficient of 0.233 (P ¼ 0.033). The subfoveal choroidal thickness was significantly different among the groups (F ¼ 3.657, P ¼ 0.017). The subfoveal choroidal thickness of the severe group was significantly thinner than that of the control group, mild group, and moderate group (P ¼ 0.023, 0.006, and 0.036, respectively). The choroidal thickness 1 mm nasal to the fovea was significantly different between the groups after correcting for age and diopter (F ¼ 3.411, P ¼ 0.023). The choroidal thickness 1 mm nasal to the fovea was significantly thinner in the severe group compared with the control group and mild group (P ¼ 0.013 and 0.010, respectively). Choroidal thickness was significantly correlated with diopter (r ¼ 0.520, R 2 ¼ 0.270, Po0.001), with a coefficient of 0.327 (Po0.001), and with ODI (r ¼ 0.520, R 2 ¼ 0.165, P ¼ 0.001), with a coefficient of À 0.370 (P ¼ 0.001). Conclusions OSAS patients showed decreased foveal and nasal macular thickness, similar to the subfoveal and nasal choroidal thickness. These findings suggest that, because of intermittent hypoxia, OSAS might change the retinal and choroidal blood supply.

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Section: Eyesupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

Chen

Wang

Zhang

et al. 2014

Eye

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“…21 In another recent study, subfoveal choroidal thickness, measured by enhanced depth imaging OCT (EDI-OCT), was not found to be significantly correlated with choroidal blood flow in young healthy eyes. 22 The authors speculated and suggested that further prospective studies are required to determine the changes in choroidal thickness during the stimulation that can cause choroidal circulation changes. In our study, we could not find a statistically significant difference in OPA between the migraine patients during attack and the control group (P ¼ ), and this may indicate that the auto regulatory mechanisms of the choroidal perfusion may overcome the decrease of the choroidal thickness in migraine patients.…”

Section: Discussionmentioning

confidence: 99%

Choroid thickness and ocular pulse amplitude in migraine during attack

Dervişoğulları

Totan

Gençler

2014

Eye

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Aim To compare the choroidal thickness and ocular pulse amplitude (OPA) measurements obtained during the attack period in migraine patients and age and gender matched control group participants using high definition optical coherence tomography (OCT). Methods Thirty eyes at the side of the headache of 30 subjects with a diagnosis of migraine with or without aura and unilateral migraine and 29 age and gender matched healthy participants were enrolled in this observational, cross-sectional study. OCT scans were performed to all participants. Choroidal thicknesses were measured at the fovea, 1500 mm nasal and 1500 mm temporal to the fovea. Intraocular pressure (IOP) and OPA were also measured. Results The choroidal thickness measurements obtained during the attack period in migraine patients were (mean ± SD) 279.82 ± 35.87, 250.05 ± 29.49, and 239.58 ± 27.92 and in control group were 308.20 ± 44.97, 276.95±41.39, and 281.60±41.38 at foveal, nasal, and temporal measurement points, respectively. Choroidal thickness significantly decreased according to the control group (Po0.05) at all measured points in migraine patients during attack. IOP (mean ± SD) values were 16.71 ± 3.26 and17.40 ± 3.19 and OPA (mean ± SD) values were 2.26 ± 0.81 and 2.64 ± 1.03 in migraine and control groups, respectively, and did not seem to be changed (P40.05). Conclusions Choroidal thickness was found to be significantly decreased in unilateral migraine patients during the attack period when compared with the control group, whereas OPA did not change. The possible implications of these findings on the association between migraine and glaucoma are discussed.

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“…1,[8][9][10][11][12][13]32 Therefore, choroidal thickness may be an additional useful clinical variable in assessing risk of AMD progression or the development of late AMD, particularly considering its apparent anatomic association with these two well-known risk factors. While a thin choroid is not necessarily related to blood flow or overall function, 50 there is evidence of regional choroidal blood flow alterations in AMD, [51][52][53][54][55] which may involve an overall decrease in blood flow and regional volume. 52,53,56 The present study is limited by small to moderate sample size, single-center study location, and predominantly Caucasian subjects.…”

Section: Discussionmentioning

confidence: 99%

Smoking and choroidal thickness in patients over 65 with early-atrophic age-related macular degeneration and normals

Sigler

Randolph

Calzada

et al. 2014

Eye

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Objective To compare macular choroidal thickness between cigarette smokers, those with a history of smoking, and nonsmokers in patients over 65 years of age with earlyatrophic age-related macular degeneration (AMD) and normals. Methods Prospective, consecutive, observational case series. Enhanced depth imaging spectral domain optical coherence tomography 12-line radial scans were performed and choroidal thickness manually quantified at 84 points in the central 3 mm of the macula. Data of normals, soft drusen alone, and soft drusen with additional features of early AMD were compared. A multivariate analysis of variance (MANOVA) model, controlling for age, was constructed to evaluate the effect of smoking history and AMD features on choroidal thickness. Results A history of smoking was significantly associated with a thinner choroid across all patients via logistic regression (P ¼ 0.004; O.R. ¼ 12.4). Mean macular choroidal thickness was thinner for smokers (148±63 mm) than for nonsmokers (181±65 mm) among all diagnosis categories (P ¼ 0.003). Subgroup analysis of patients with AMD features revealed a similar decreased choroidal thickness in smokers (121 ± 41 mm) compared with nonsmokers (146 ± 46 mm, P ¼ 0.006). Bivariate analysis revealed an association between increased pack-years of smoking and a thin choroid across all patients (Po0.001) and among patients with features of early AMD (Po0.001). Both the presence of features of macular degeneration (Po0.001) and a history of smoking (P ¼ 0.024) were associated with decreased choroidal thickness in a MANOVA model. ConclusionChronic cigarette smoke exposure may be associated with decreased choroidal thickness. There may be an anatomic sequelae to chronic tobacco smoke exposure that underlies previously reported AMD risk.

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Relationship Between Choroidal Thickness and Choroidal Circulation in Healthy Young Subjects

Cited by 115 publications

References 21 publications

Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS)

Choroid thickness and ocular pulse amplitude in migraine during attack

Smoking and choroidal thickness in patients over 65 with early-atrophic age-related macular degeneration and normals

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