Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt–Koyanagi–Harada disease

Hirooka, Kiriko; Saito, Wataru; Namba, Kenichi; Takemoto, Yuko; Mizuuchi, Kazuomi; Uno, Tomoe; Tagawa, Yoshiaki; Hashimoto, Yuki; Ishida, Susumu

doi:10.1007/s00417-014-2927-5

Cited by 78 publications

(82 citation statements)

References 21 publications

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“…In addition, excellent visual acuity was maintained over long-term follow-up, indicating that initial use of pulse intravenous corticosteroids in new-onset acute VKH disease may lead to long-term good visual outcomes and low rates of recurrence and complications. Our results are superior to a Japanese study by Hirooka and colleagues reporting that 69% of eyes with acute VKH disease achieved a visual acuity of 1.0 or better at 1 month 18. Of note in that study, patients received lower starting corticosteroid doses of prednisolone 200 mg/day.…”

Section: Discussioncontrasting

confidence: 83%

Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids

et al. 2018

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Section: Discussioncontrasting

confidence: 83%

Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids

et al. 2018

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“…At the initial onset of VKH disease, patients usually show signs of panuveitis or posterior uveitis with serous retinal detachment. Indocyanine green angiography (ICGA) and laser speckle flowgraphy reveal impaired choroidal circulation,4 5 and enhanced depth imaging optical coherence tomography (EDI-OCT) shows the markedly thickened choroid in eyes with VKH disease 5–7…”

Section: Introductionmentioning

confidence: 99%

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

et al. 2015

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Sub-title:Choroidal thickening was detected in the anterior segment recurrence of Vogt-Koyanagi-Harada disease by enhanced depth imaging optical coherence tomography, and this thickening was observed prior to the recurrence. ABSTRACTAim To assess choroidal thickness changes associated with anterior segment recurrences in patients with Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography (EDI-OCT).Methods EDI-OCT images were obtained periodically from 11 VKH disease patients (22 eyes) who were followed-up due to anterior segment recurrences.Subfoveal choroidal thickness (SCT) values at the following stages were evaluated: (1) during the remission phase, (2) one month before detecting the anterior recurrence, (3) during the anterior recurrence, and (4) after systemic prednisolone (PSL) treatment leading to remission. In comparison with SCT values in remission as baseline, the changing ratios of SCT were statistically analyzed at subsequent three stages. ResultsThe average of the SCT changing ratios compared to the remission phase significantly increased to 1.45 ± 0.11 during anterior segment recurrences (P=0.00044) lacking any funduscopic signs of posterior involvement. Interestingly, the average SCT ratio one month before detecting the recurrence had already increased to 1.30 ± 0.08 (P=0.002). After the PSL treatment, the ratio of SCT recovered to 0.95 ± 0.03 which 3 was equivalent with the remission level. However, in patients with their remission SCT values less than 240 µm, the SCT ratio did not increase significantly at any time points evaluated.

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“…17,33,47 Recent results also suggest that systemic corticosteroid therapy ameliorates the inflammation-related impairment of choroidal blood flow velocity in the macula of VKH patients. 17 In that study, LSFG was used to evaluate the effect of systemic corticosteroid administration by comparing measurements of blood flow velocity, which is considered to reflect inflammation activity in the choroid.…”

Section: Monitoring Ocular Circulationmentioning

confidence: 99%

“…17 Furthermore, decreased MBR and increased choroidal thickness, as measured with optical coherence tomography (OCT), have been reported to be mutually linked and to be related to the pathogenesis of VKH. 47 Thus, LSFG might be useful as an index for evaluating the activity of choroiditis in VKH, as a supplement to OCT. 47 In eyes with CSC, a negative correlation has been shown between visual recovery and decreased MBR with the regression of the disease, indicating that increase in macular choroidal MBR may be associated with a poor visual prognosis. 33 Moreover, the finding that MBR decreases concurrently with the regression of CSC provides additional evidence for the role of elevated choroidal blood flow in the pathogenesis of acute CSC.…”

Section: Monitoring Ocular Circulationmentioning

confidence: 99%

Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease

Kunikata¹,

Nakazawa²

2016

Asia-Pacific Journal of Ophthalmology

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Retinal diseases related to ischemia, such as diabetic retinopathy, are the main cause of blindness worldwide. However, the pathogenesis of these diseases remains unclear, as does the time course of associated changes in ocular blood flow. Laser speckle flowgraphy (LSFG), which uses the laser speckle phenomenon to detect and quantify ocular circulation, is a promising candidate for a noninvasive method to measure ocular blood flow in living eyes. A recently developed LSFG measurement parameter, mean blur rate (MBR), can serve as a quantitative and reproducible index of retinal blood cell velocity. Mean blur rate can be used in the study of retinal diseases to evaluate microcirculation in the retinal vessels, choroid, and optic nerve head. In addition to overall MBR (MA), LSFG measurements of optic nerve head microcirculation can be divided into vessel-area MBR (MV) and tissue-area MBR (MT). Absolute values for MT have been shown to be linearly correlated with capillary blood flow, regardless of fundus pigmentation. Recently, there has been an increasing number of reports on the clinical applications of LSFG in retinal disease.

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Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt–Koyanagi–Harada disease

Abstract: Our data suggest that circulatory disturbances and increased thickness of the choroid relate to the pathogenesis of VKH disease with link mutually. LSFG is useful as an index for evaluating the choroiditis activity of VKH disease as well as EDI-OCT.

Cited by 78 publications

References 21 publications

Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids

Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids

Choroidal thickening prior to anterior recurrence in patients with Vogt–Koyanagi–Harada disease

Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease

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