Relationship between childhood trauma and resilience in patients with mood disorders

Park, Ji Yoon; Lee, Chan Woo; Jang, Yoonjeong; Lee, Wonyun; Yu, Hyeona; Yoon, Joohyun; Oh, Sunghee; Park, Yun Seong; Ryoo, Hyun A; Lee, Jangwon; Cho, Nayoung; Lee, Chong Hun; Lee, Yeong Chan; Won, Hong‐Hee; Kang, Hyo Shin; Ha, Tae Hyon; Myung, Woojae

doi:10.1016/j.jad.2022.11.003

Cited by 2 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the significant differences between brain regions in MDD-CT and MDD-nCT might be due to differing levels of resilience among individuals with CT. Evidence suggests that CT can have varying impacts on an individual’s resilience ( 44 ), so those with experiences of CT might develop different outcomes (depression or non-depression) based on their resilience.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma

Zhao,

Rong,

Gao

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

ObjectivesMajor Depressive Disorder (MDD) is significantly influenced by childhood trauma (CT), affecting brain anatomy and functionality. Despite the unique disease trajectory in MDD patients with CT, the underlying neurobiological mechanisms remain unclear. Our objective is to investigate CT’s impact on the white matter structure of the brain in patients with MDD.MethodsThis research employed tract-based spatial statistics (TBSS) to detect variations between groups in Fractional Anisotropy (FA) throughout the whole brain in 71 medication-free MDD patients and 97 HCs. Participants filled out the Childhood Trauma Questionnaire (CTQ) and assessments for depression and anxiety symptoms. The relationship between FA and CTQ scores was explored with partial correlation analysis, adjusting for factors such as age, gender, educational background, and length of illness.ResultsCompared to HCs, the MDD group showed decreased FA values in the right posterior limb of the internal capsule (PLIC), the inferior fronto-occipital fasciculus (IFOF), and bilateral superior longitudinal fasciculus (SLF). Simple effects analysis revealed that compared to HC-CT, the MDD-CT group demonstrated decreased FA values in right PLIC, IFOF, and bilateral SLF. The MDD-nCT group showed decreased FA values in right PLIC and IFOF compared to HC-nCT. The total scores and subscale scores of CTQ were negatively correlated with the FA in the right SLF.ConclusionThe right SLF may potentially be influenced by CT during the brain development of individuals with MDD. These results enhance our knowledge of the role of the SLF in the pathophysiology of MDD and the neurobiological mechanisms by which CT influences MDD.

show abstract

Section: Discussionmentioning

confidence: 99%

Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma

Zhao,

Rong,

Gao

et al. 2024

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Childhood maltreatment and sexual abuse have been identified as risk factors for depression in adults (Hill, 2009; Nelson et al, 2002); this relationship is dose-specific, suggesting that the more trauma one reports throughout childhood, the more severe their adult depression symptoms (Negele et al, 2015). Early exposure to trauma has been found to impact resilience in adulthood and may therefore deplete an individual’s ability to recover from stressful events later in life (Park et al, 2023). Childhood trauma also moderates the effects of stressors experienced in adulthood, further increasing the chances that individuals will become depressed after experiencing stressful events (Colman et al, 2013).…”

Section: Tpmentioning

confidence: 99%

Depression symptom changes in triphasic trauma therapy: Initial findings from a community-based observational study.

Norton,

Harmsen,

Corderio

et al. 2024

Journal of Psychotherapy Integration

View full text Add to dashboard Cite

Relationship between childhood trauma and resilience in patients with mood disorders

Cited by 2 publications

References 40 publications

Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma

Alterations in the white matter structure of major depressive disorder patients and their link to childhood trauma

Depression symptom changes in triphasic trauma therapy: Initial findings from a community-based observational study.

Contact Info

Product

Resources

About