Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset

Pignon, Baptiste; Lajnef, Mohamed; Godin, O.; Geoffray, Marie-Maud; Roux, Paul; Passerieux, Christine; Marulaz, Laurent; Dubreucq, Julien; Leignier, Sylvain; Meynier, André; Chéreau, Isabelle; Llorca, Pierre‐Michel; Fond, Guillaume; Lançon, Christophe; Leboyer, Marion; Schürhoff, Franck; Andrianarisoa, M.; Aouizerate, Bruno; Berna, Fabrice; Blanc, Olivier; Brunel, L.; Bulzacka, E.; Capdevielle, Delphine; Chéreau-Boudet, I.; Chesnoy-Servanin, G.; Danion, J.M.; d’Amato, Thierry; Deloge, A.; Delorme, C.; Denizot, H.; Dorey, Jean‐Michel; Dubertret, Caroline; Dubreucq, Jean-Luc; Faget, Catherine; Fluttaz, C.; Fonteneau, S.; Gabayet, Franck; Giraud-Baro, É.; Hardy-Baylé, Marie-Christine; Lacelle, D.; Laouamri, H.; Gloahec, T. Le; Strat, Yann Le; Llorca, P.M.; Mallet, J.; Metairie, E.; Misdrahi, D.; Offerlin-Meyer, I.; Passerieux, C.; Peri, P.; Pires, S.; Portalier, C.; Rey, Romain; Román, C.; Sebilleau, M.; Schandrin, A.; Tessier, A.; Tronche, A.M.; Urbach, M.; Vaillant, F.; Véhier, A.; Vidailhet, Pierre; Vilà, E.; Yazbek, Hanan; Zinetti-Bertschy, A.

doi:10.1016/j.schres.2019.04.006

Cited by 10 publications

(7 citation statements)

References 67 publications

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“…Although our study findings were similar to those of the study (Pignon et al, 2019) investigating negative symptoms and EA in 294 patients with schizophrenia, contradictory findings from two studies conducted in our country and the study by Rajkumar et al were also reported (Güler, 2014; Kilicaslan et al, 2017; Rajkumar, 2015). In 2016, in the 1-year follow-up study of 96 patients with a first episode of psychosis, a relationship was not found between negative symptoms with CT and subscales (Aas et al, 2016).…”

Section: Discussionsupporting

confidence: 89%

The effect of childhood trauma on age of onset in patients with schizophrenia

İngeç

Kılıçaslan

2020

Int J Soc Psychiatry

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Purpose: Childhood trauma (CT) has been shown to affect the etiology and clinical features of schizophrenia. In this study, it was aimed to investigate the effects of CT on the age of onset (AoO) and clinical features of the disease by considering factors such as family history, head trauma, birth trauma, alcohol and substance abuse that may affect AoO of the disease. Methods: The sample comprising 200 patients admitted to the outpatient and inpatient care at the Izmir Katip Çelebi University, Atatürk Education and Research Hospital psychiatry clinic, were included in the study. Socio-demographic information form, Positive and Negative Syndrome Scale (PANSS), Childhood Trauma Questionnaire-Short Form (CTQ-SF) and subscale of Mini-International Neuropsychiatric Interview (MINI) were applied. Results: All types of trauma, except physical abuse, were found related to the disease onset age earlier. It was also detected that the factors of head trauma, birth complication, presence of an individual diagnosed with schizophrenia in the family and migration history were not related to AoO of the disease. On the other hand, it was found that physical, emotional and sexual abuses lead to more positive psychotic symptoms, and all types of CT increase the severity of disease and the risk of suicide. Conclusion: This study draws attention to the etiological importance of CT in schizophrenia as an environmental factor by showing that it affects AoO of the disease along with symptomatology. Future studies should focus on the pathogenesis of CT in schizophrenia and the interaction between CT and biological and genetic predisposition.

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Section: Discussionsupporting

confidence: 89%

The effect of childhood trauma on age of onset in patients with schizophrenia

İngeç

Kılıçaslan

2020

Int J Soc Psychiatry

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“…Since childhood trauma is a risk factor both for schizophrenia and violence, we expected significantly higher CTQ scores in both SCZ-V and SCZ-NV compared to HC. Our predominantly male SCZ-NV group had a median score of 33.5 for total trauma, which is in line with the results from previous studies of childhood trauma and specifically CTQ-scores on mixed gender schizophrenia samples (33)(34)(35)(36). Moreover, our SCZ-V group had a median score of total trauma of 55, which was significantly higher than our two control groups and clearly higher than the mean or median values found in most general schizophrenia studies as cited above.…”

Section: Total Childhood Trauma Exposuresupporting

confidence: 90%

“…Childhood trauma is not only related to violence in schizophrenia but also with poorer outcomes (36). The specific mechanisms underpinning this association are not known.…”

Section: Total Childhood Trauma Exposurementioning

confidence: 99%

Childhood Trauma in Persons With Schizophrenia and a History of Interpersonal Violence

et al. 2020

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Background: Childhood trauma is a risk factor for psychosis as well for violent behavior and offending later in life. Childhood trauma comprises subdomains of abuse and neglect that may be differently related to later violence among patients with schizophrenia. The aim of this study was to map the subdomains of childhood trauma associated with violent offending in schizophrenia. Methods: Information on childhood trauma from predominantly male patients with a DSM-IV diagnosis of schizophrenia and a history of violent offending (interpersonal violence) (SCZ-V, n = 19), schizophrenia patients without a history of violence (SCZ-NV, n = 34), and healthy controls (HC, n = 66) was obtained with the Childhood Trauma Questionnaire (CTQ). Differences between groups in total maltreatment scores and the five subdomains including physical, emotional, and sexual abuse, as well as physical and emotional neglect were analyzed. Results: SCZ-V had the highest median CTQ scores for all sub-domains. SCZ-V reported significantly higher total CTQ scores than SCZ-NV and HC. SCZ-V had significantly higher scores than HC on all subdomains, and significantly higher than SCZ-NV on physical and emotional neglect. SCZ-NV had higher scores on all domains except sexual abuse compared to HC. Conclusion: SCZ-V patients had higher exposure to childhood trauma than SCZ-NV, and both schizophrenia groups had higher exposure than HC. The results suggest that childhood physical and emotional neglect may be of specific importance to later violence in schizophrenia.

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“…Other aspects associated with CT in schizophrenia include inflammatory biomarkers, 17 , 18 body-mass index, 19 telomere length, 19 hair cortisol concentration, 20 suicide, 21 , 22 violence, 23 insight, 24 quality of life, 25 social cognition, 26 and social functioning. 27 , 28 …”

Section: Introductionmentioning

confidence: 99%

Childhood trauma is associated with age at onset of symptoms, functioning, and cognition in patients with schizophrenia

De-Nardin¹,

Muratori²,

Ribeiro³

et al. 2021

Trends Psychiatry Psychother

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Introduction Childhood trauma (CT) is known to be a vulnerability factor for schizophrenia, but the specific impacts of different trauma subtypes on the prognosis of these patients remains unclear. Objective To assess the relationships between the occurrence of overall CT and its subtypes with factors with known prognostic impact on schizophrenia, such as age at onset of symptoms, global functioning, and cognitive impairment in a sample of Brazilian patients. Methods One hundred and five stable patients diagnosed with schizophrenia according to DSM-5 criteria were evaluated using the Independent Living Skills Survey (ILSS; self-report global functioning), Schizophrenia Cognition Rating Scale (SCoRS; subjective cognitive impairment), and Childhood Trauma Questionnaire scales (CTQ; perceived overall CT, emotional neglect, physical neglect, physical abuse, and emotional and sexual abuse). Statistical analysis was performed with multivariate linear regression. Results After controlling for educational level and age, subjective cognitive impairment was directly correlated with overall perceived CT occurrence, emotional abuse, and sexual abuse. Self-report global functioning was inversely correlated with perceived overall CT occurrence, emotional abuse, and sexual abuse. Emotional abuse and physical abuse were also inversely correlated with age at onset of symptoms. Conclusions CT can be related to more severe prognoses in schizophrenia, impacting on early onset of symptoms, lower global functioning, and greater cognitive impairment. Subtypes of trauma can be associated with different prognostic risks.

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Relationship between childhood trauma and level of insight in schizophrenia: A path-analysis in the national FACE-SZ dataset

Cited by 10 publications

References 67 publications

The effect of childhood trauma on age of onset in patients with schizophrenia

The effect of childhood trauma on age of onset in patients with schizophrenia

Childhood Trauma in Persons With Schizophrenia and a History of Interpersonal Violence

Childhood trauma is associated with age at onset of symptoms, functioning, and cognition in patients with schizophrenia

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