Relationship between Childhood Adversities, Emotion Dysregulation and Cognitive Processes in Bipolar Disorder and Recurrent Depressive Disorder

Yenilmez, Dicle; Atagün, Murat İlhan; Altun, İlkay Keleş; Tunç, Serhat; Uzgel, Mine; Altınbaş, Kürşat; Cesur, Gizem; Oral, Elif

doi:10.5080/u23415

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…In our study, it was observed that individuals both in the BD and MDD groups had significantly more difficulties in emotion regulation than the healthy controls. These results are consistent with previous findings (24,25). Studies are reporting that depression is a differentiation in emotion processing due to dysregulation of negative affect (26).…”

Section: Discussionsupporting

confidence: 93%

Emotion Dysregulation Affects Functionality in Major Depressive Disorder

Altun

2023

Acibadem Univ Saglik Bilim Derg

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Purpose: Mood disorders are recurrent chronic mental illnesses known to affect functionality. In this study, it was aimed to compare coping strategies and emotion regulation difficulties in depression and bipolar disorder and observe the effects of coping strategies and emotion regulation on functionality. Methods: 31 patients with bipolar disorder (BD), 29 with major depressive disorder (MDD), and 27 healthy controls (HC) were included in the study. Participants completed the Coping Strategies Inventory (COPE), Bipolar Disorder Functioning Questionnaire (BDFQ), Difficulties in Emotion Regulation Scale (DERS), Hamilton Depression Scale (HAM-D), and Young Mania Rating Scale (YMRS). Results: In the BD group, a positive significant correlation was found between COPE-M and DERS scores, and a negative significant correlation was found between COPE-M and BDFQ. In the MDD group, a positive significant correlation was found between COPE-A and BDFQ scores, and a negative significant correlation was found between DERS and BDFQ. BDFQ was statistically significantly predicted positively by COPE-A and negatively by DERS. Conclusion: It was thought that emotion dysregulation may predispose to depressive symptomatology and negatively affect clinical course and functionality. Addressing emotion regulation difficulties and increasing the use of adaptive coping strategies in therapeutic interventions contribute to the improvement of functionality as well as clinical improvement.

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Section: Discussionsupporting

confidence: 93%

Emotion Dysregulation Affects Functionality in Major Depressive Disorder

Altun

2023

Acibadem Univ Saglik Bilim Derg

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“…In studies comparing BD and MDD, the following comparisons became significant after the leave-one-out sensitivity analysis: (i) ‘ reflective pondering ’ subscale of the RRS, by removing the study (Aslan & Baldwin, 2021 ), (ii) ‘ putting into perspective ’ subscale of the CERQ, by removing the study (Wolkenstein, Zwick, Hautzinger, & Joormann, 2014 ), and (iii) ‘ goals ’ subscale of the DERS, by removing the study (Oymak Yenilmez et al, 2021 ), all passing from a small to a small-to-moderate effect size; (iv) ‘ awareness ’ subscale of the DERS, by removing the study (Musket, Hansen, Welker, Gilbert, & Gruber, 2021 ), passing from a small-to-moderate to a moderate effect size. On the contrary, by removing the studies ([Becerra et al, 2013 ], [Becerra, Bassett, & Harms, 2016 ], or [Weintraub, Van de Loo, Gitlin, & Miklowitz, 2017 ]) in the comparison relative to the ‘ clarity ’ subscale of the DERS, the overall effect became nonsignificant with an effect size comparable in magnitude.…”

Section: Resultsmentioning

confidence: 99%

“…When the prediction intervals are the same as the confidence interval, the p-value is the same. In the two cases where the significant prediction intervals are different from the confidence intervals, their p-value is ≤ 0.01. comparisons related to each mentioned subscale): (i) in the 'putting into perspective' subscale of the CERQ, subsets including the study (Wolkenstein et al, 2014) presented higher heterogeneity and lower effect size; (ii) in the 'positive refocusing' subscale of the CERQ, subsets including the study (Ariana Kia & Hasani, 2014) presented higher heterogeneity and effect size; (iii) in the 'refocus on planning' subscale of the CERQ, subsets including the study (Kjaerstad et al, 2016) presented higher heterogeneity and effect size; (iv) in the 'goals' subscale of the DERS, subsets including the study (Oymak Yenilmez et al, 2021) presented higher heterogeneity and opposite effect size; (v) in the 'non acceptance' subscale of the DERS, subsets including the study (Oymak Yenilmez et al, 2021) presented higher heterogeneity and opposite effect size; and (vi) in the 'awareness' subscale of the DERS, subsets including the study (Musket et al, 2021) presented higher heterogeneity and lower effects size. By inspecting the GOSH plots in the studies comparing BD and BPD and exploring differences in the total DERS score, subsets including the study (Das, Calhoun, & Malhi, 2014) presented higher heterogeneity and effect size.…”

Section: Sensitivity Analysesmentioning

confidence: 99%

“…Whether these differences are characteristics of BD or are due to a common psychopathological burden shared by many psychiatric disorders requires further investigation. Indeed, studies focusing on differences in ED between BD and MDD reported mixed results, and higher levels of overall ED were described in both the former (Oymak Yenilmez et al, 2021 ) and the latter (Becerra et al, 2013 ). As ED appears to be a transdiagnostic dimension and a potential target for personalized interventions, it is important to define the extent to which certain features are specific to BD or shared with other psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

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Emotion dysregulation in bipolar disorder compared to other mental illnesses: a systematic review and meta-analysis

De Prisco,

Oliva,

Fico

et al. 2023

Psychol. Med.

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People with bipolar disorder (BD) often present emotion dysregulation (ED), a pattern of emotional expression interfering with goal-directed behavior. ED is a transdiagnostic construct, and it is unclear whether it manifests itself similarly in other conditions, such as major depressive disorder (MDD) or borderline personality disorder (BPD), or has specific features in BD. The present systematic review and meta-analysis explored ED and adopted emotion regulation (ER) strategies in BD compared with other psychiatric conditions. PubMed/MEDLINE, EMBASE, Scopus, and PsycINFO databases were systematically searched from inception to April 28th, 2022. Studies implementing validated instruments assessing ED or ER strategies in BD and other psychiatric disorders were reviewed, and meta-analyses were conducted. Twenty-nine studies yielding multiple comparisons were included. BD was compared to MDD in 20 studies (n = 2451), to BPD in six studies (n = 1001), to attention deficit hyperactivity disorder in three studies (n = 232), to anxiety disorders in two studies (n = 320), to schizophrenia in one study (n = 223), and to post-traumatic stress disorder in one study (n = 31). BD patients did not differ from MDD patients in adopting most adaptive and maladaptive ER strategies. However, small-to-moderate differences in positive rumination and risk-taking behaviors were observed. In contrast, patients with BPD presented an overall higher degree of ED and more maladaptive ER strategies. There were insufficient data for a meta-analytic comparison with other psychiatric disorders. The present report further supports the idea that ED is a transdiagnostic construct spanning a continuum across different psychiatric disorders, outlining specific clinical features that could represent potential therapeutic targets.

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“… 32 In addition, studies have shown that childhood trauma can predict worse cognitive function in people with depressive disorders and bipolar disorder. 33 …”

Section: Discussionmentioning

confidence: 99%

Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume

Wang¹,

Yin²,

Feng³

et al. 2022

jpn

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Background: A line of evidence has shown that childhood trauma and patterns of H-shaped sulci in the orbitofrontal cortex (OFC) are associated with cognitive deficits in patients with schizophrenia. Studies have also suggested that childhood trauma is associated with OFC volumetrics. This study investigated the interrelationship between childhood trauma, OFC H-shaped sulci volume and cognitive function in patients with first-episode schizophrenia. We hypothesized that OFC H-shaped sulci volume would mediate the relationship between childhood trauma and cognitive function in patients with first-episode schizophrenia. Methods: We recruited patients with first-episode schizophrenia ( n = 63) and healthy controls ( n = 48), and quantified OFC H-shaped sulci volumes with 3.0 T high-resolution MRI. We assessed cognitive function and childhood trauma experiences using the MATRICS Consensus Cognitive Battery (MCCB) and the Childhood Trauma Questionnaire (CTQ). Results: Patients with first-episode schizophrenia had smaller left OFC H-shaped sulci volumes, more severe childhood trauma experiences and worse cognitive function than healthy controls. CTQ total score and emotional and physical neglect subscores were negatively correlated with left OFC H-shaped sulci volume. CTQ total score and emotional neglect and sexual abuse subscores were negatively correlated with cognitive function in patients with first-episode schizophrenia. Interestingly, the CTQ total score and physical neglect subscore were positively correlated with cognitive function in healthy controls. Left OFC H-shaped sulci volume played a mediating role in CTQ emotional neglect subscore, CTQ total score and MCCB composite score. Limitations: The small sample size and retrospective design need to be considered. Conclusion: Childhood trauma might contribute to cognitive deficits in patients with first-episode schizophrenia by affecting left OFC H-shaped sulci volume. This finding can help in the design of strategies to improve cognitive function in patients with first-episode schizophrenia.

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Relationship between Childhood Adversities, Emotion Dysregulation and Cognitive Processes in Bipolar Disorder and Recurrent Depressive Disorder

Cited by 4 publications

References 9 publications

Emotion Dysregulation Affects Functionality in Major Depressive Disorder

Emotion Dysregulation Affects Functionality in Major Depressive Disorder

Emotion dysregulation in bipolar disorder compared to other mental illnesses: a systematic review and meta-analysis

Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume

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