Relationship between chemical structure and anticonvulsive activity in 4,4′-(α, ω-alkylenedioxy)diphenylsuccinimides

27‐ to 39‐Membered Pyridine Macrocycles

“…Whereas pyridine 8 is known in the literature, [11] benzyl alcohols 14 have to be synthesized from 4-hydroxybenzoic ester (9) or 4-hydroxybenzyl alcohol (12) and suitable alkenyl derivatives 10 or 13. In principle, the alkylation can be carried out by using Williamson ether formation or by the Mitsunobu reaction.…”

“…The residue was recrystallized. See also: 6a, [12] 6b, [6] 6c, [13] 6d. [14] General Procedure B for Reduction of 6 to 7: To a solution of 1,ω-bis(4-formylphenoxy)alkane (6, 1 equiv.)…”

Structure‐Activity Relationship Studies of 1‐Substituted 3‐Dodecanoylindole‐2‐carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2‐Mediated Arachidonic Acid Release in Intact Platelets

“…Therefore, we synthesized analogues of 4, in which the ethoxy group located between the indole and the benzoic acid part of the molecule was replaced by propoxy (21), butoxy (22), pentoxy (23), and octyloxy (24) moieties. Extending the alkoxy spacer from 3 to 9 atoms did not seriously change the activity.…”

“…The solution of 4-(2-bromoethoxy)benzaldehyde [22] (573 mg, 2.5 mmol), diethyl malonate (561 mg, 3.5 mmol) and piperidine (10 drops) in toluene (25 mL) was refluxed at a water separator for 2 h. After cooling, the mixture was diluted with water and extracted with ether. The organic phase was dried over Na 2 SO 4 and the solvent was evaporated to dryness.…”