Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease

Abstract

BackgroundChemerin is a novel adipokine that is associated with inflammation and adipogenesis. However, it remains unclear whether chemerin is involved in patients with cardiovascular disease. We investigated whether the serum chemerin levels of Korean patients with coronary artery disease correlated with specific cardiometabolic parameters.MethodsIn total, 131 patients, all of whom had coronary artery stenosis exceeding 50%, participated in this study. Their serum chemerin levels and cardiometabolic parameters were measured. The serum chemerin levels of two groups of patients were compared; those with one stenotic vessel (n=68) and those with multiple stenotic vessels, including left main coronary artery disease (n=63).ResultsSerum chemerin levels correlated positively with the degree of coronary artery stenosis and fasting glucose, triglyceride, total cholesterol, low density lipoprotein cholesterol, and high sensitive C-reactive protein levels. The group with multiple stenotic vessels, including left main disease, had higher chemerin levels than the group with one stenotic vessel (t=-2.129, P=0.035). Multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease (odds ratio, 1.018; confidence interval, 0.997 to 1.040; P=0.091).ConclusionSerum chemerin levels have a significant correlation with several cardiometabolic risk factors and the degree of coronary artery stenosis in Korean patients with coronary artery disease. However, multiple binary logistic regression showed chemerin was not an independent risk factor of multiple vessel disease. Additional investigations are necessary to fully elucidate the role of chemerin in cardiovascular disease.

Chemerin as an independent predictor of cardiovascular event risk

“…In this study, positive correlations were reported between serum chemerin levels and fasting glucose, triglycerides, total cholesterol, and High-sensitivity C-reactive protein (HsCRP) [Hah et al 2011]. A correlation between circulating chemerin levels and CAD severity were found in recent case-control studies.…”

“…Also, Dong and colleagues have found higher levels of chemerin in MetS patients with CAD in comparison with MetS patients without CAD [Dong et al 2011] (Table 2). Although significantly high serum chemerin levels were found in CAD, it is not clearly known if this increased level represents a predictor for CAD or is a result of atherosclerotic plaque morphology [Lehrke et al 2009;Hah et al 2011]. …”

The Adipokine Chemerin Induces Apoptosis in Cardiomyocytes

“…Chemerin has indeed been proposed as a predictive marker of cardiovascular risk [27,28], and previous works have demonstrated that circulating chemerin concentrations correlate with several cardiometabolic parameters and with the severity of coronary artery disease [29][30][31]. Moreover, chemerin and CMKLR1 genes are both expressed by cells of the cardiovascular system, in which their levels have been shown to be positively correlated with the severity of cardiac pathologies such as atherosclerosis [32].…”

Chemical Pathology of Chemerin and Its Link to Obesity and Type 2 Diabetes Mellitus: A Review

“…In recent times, the adipose tissue is increasingly being recognized as an active endocrine organ [6,7]. This is so, as many molecules such as vaspin, omentin, adiponectin and a host of other Ekpe E. E. and Ekpe V. E.: Chemical Pathology of Chemerin and Its Link to Obesity and Type 2 Diabetes Mellitus: A Review molecules are derived from the adipocytes [8,9].…”