Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury

Reid, Susan M; Ditchfield, Michael; Bracken, Jenny; Reddihough, Dinah

doi:10.1016/j.ridd.2015.07.030

Cited by 20 publications

(23 citation statements)

References 38 publications

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“…This could mean that these connections, although not shown as affected in all CP subjects, could be injured in the most severe cases, which would have a larger brain injury. This would fit with qualitative MRI studies in which the extent of brain lesion has been strongly associated with motor impairment [Arnfield et al, ; Reid et al, ]. Second, we observe a greater number of connections to the frontal lobe, specifically prefrontal areas, the left temporal lobe and the occipital lobe.…”

Section: Discussionsupporting

confidence: 86%

Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function

et al. 2017

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Dyskinetic cerebral palsy (CP) has long been associated with basal ganglia and thalamus lesions. Recent evidence further points at white matter (WM) damage. This study aims to identify altered WM pathways in dyskinetic CP from a standardized, connectome-based approach, and to assess structure-function relationship in WM pathways for clinical outcomes. Individual connectome maps of 25 subjects with dyskinetic CP and 24 healthy controls were obtained combining a structural parcellation scheme with whole-brain deterministic tractography. Graph theoretical metrics and the network-based statistic were applied to compare groups and to correlate WM state with motor and cognitive performance. Results showed a widespread reduction of WM volume in CP subjects compared to controls and a more localized decrease in degree (number of links per node) and fractional anisotropy (FA), comprising parieto-occipital regions and the hippocampus. However, supramarginal gyrus showed a significantly higher degree. At the network level, CP subjects showed a bilateral pathway with reduced FA, comprising sensorimotor, intraparietal and fronto-parietal connections. Gross and fine motor functions correlated with FA in a pathway comprising the sensorimotor system, but gross motor also correlated with prefrontal, temporal and occipital connections. Intelligence correlated with FA in a network with fronto-striatal and parieto-frontal connections, and visuoperception was related to right occipital connections. These findings demonstrate a disruption in structural brain connectivity in dyskinetic CP, revealing general involvement of posterior brain regions with relative preservation of prefrontal areas. We identified pathways in which WM integrity is related to clinical features, including but not limited to the sensorimotor system. Hum Brain Mapp 38:4594-4612, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 86%

Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function

et al. 2017

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“…14e16 Different neuroimaging and physiological techniques have been implemented in attempts to understand the phenomenon of neuroplasticity and its implications for intervention. 14,17,18 Interpreting neuroplastic adaptations during infant and child development is confounded by variations in sample selection (natural and therapeutic environmental influences on development), tolerance of children to different procedures, and most likely also the choice of the techniques and methodologies employed. For example, Reid et al 17 recently reported on the challenges of interpreting taskfocused functional magnetic resonance imaging (fMRI).…”

Section: Introductionmentioning

confidence: 99%

Understanding the relationship between brain and upper limb function in children with unilateral motor impairments: A multimodal approach

Weinstein

Green

Rudisch

et al. 2018

European Journal of Paediatric Neurology

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The current results demonstrate benefits from the use of different modalities when studying upper-limb function in children with CP; not least to accommodate to the variations in tolerance and feasibility of implementation of the differing methods. These exposed multiple individual brain-reorganization patterns corresponding to different functional motor abilities. Additional research is warranted to understand the transactional influences of early brain injury, neuroplasticity and developmental and environmental factors on hand function in order to develop targeted interventions.

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“…These findings were used by the authors to create a new WMI severity classification for children with CP that could provide valuable predictors of future function to families. [1]…”

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confidence: 99%

MRI and Motor Outcomes in Children with Cerebral Palsy

Gaebler-Spira

McCormick

2015

Pediatr Neurol Briefs

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Relationship between characteristics on magnetic resonance imaging and motor outcomes in children with cerebral palsy and white matter injury

Cited by 20 publications

References 38 publications

Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function

Whole-brain structural connectivity in dyskinetic cerebral palsy and its association with motor and cognitive function

Understanding the relationship between brain and upper limb function in children with unilateral motor impairments: A multimodal approach

MRI and Motor Outcomes in Children with Cerebral Palsy

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