Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment

Jiménez, Miguel Valle; Martos, Rosario; Morales, Rosario; Valle, Rosario; Cañete, María Dolores; Urbano, Maria M.; Bermudo, Francisco Martín; Cañete, Ramón

doi:10.1159/000351597

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…In total, 68 studies reported metabolic measures and details of these are listed in Table , alongside the outcome(s) of interest from each study. While various glucose measures were reported, we focused on fasting‐glucose measurements for this article (56 studies), as fasting glucose is used clinically to identify prediabetes and diabetes.…”

Section: Resultsmentioning

confidence: 99%

Change in obesity‐related metabolic abnormalities associated with body mass index improvement through life‐style intervention: A meta‐regression

et al. 2019

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The reduction in body mass index standard deviation score (BMI-SDS) associated with improvement in biomarkers relating to metabolic health in obese children is unknown.We aimed to establish the change in BMI-SDS associated with improved inflammation, liver function, and insulin resistance to inform clinical guidelines for pediatric weight management interventions and to assess the efficacy of future trials. A large-scale systematic review was conducted to identify relevant studies. Studies of children with a diagnosis of obesity according to defined BMI thresholds, participating in lifestyle interventions to reduce obesity, were included. Studies must have reported baseline (pre-) and postintervention (or change of) BMI-SDS and either fasting glucose, homeostatic model of insulin resistance (HOMA-IR), alanine aminotransferase (ALT), C-reactive protein (CRP), or interleukin-6 (IL-6). A series of meta-regressions were conducted to establish links between BMI-SDS change scores and change in metabolic markers of health. Sixty-eight articles were identified. From the meta-regression analyses, across all study subsets, greater mean falls in all four parameters, (HOMA-IR, Glucose, ALT, and CRP) were observed with greater mean loss of BMI-SDS, but the trends were only statistically significant for HOMA-IR and CRP (P = .003; P = .021). However, we could not find minimum changes in BMI-SDS that would ensure a fall in these outcomes. At this time, we are unable to recommend a definitive value of BMI-SDS reduction needed to improve the markers of metabolic health. Future trials should aim to report additional indices of derived BMI values, which may better reflect changes in actual adiposity. K E Y W O R D SBMI-SDS, insulin resistance, metabolic health, meta-regression, obesity

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Section: Resultsmentioning

confidence: 99%

Change in obesity‐related metabolic abnormalities associated with body mass index improvement through life‐style intervention: A meta‐regression

et al. 2019

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“…Because of the expansion of adipose tissue and development of insulin resistance [6], inflammatory markers and cytokines are released and affect other tissues, such as the liver and skeletal muscle [7]. In obese children, lower levels of plasma adiponectin [8], as well as higher levels of leptin [9,10], C-reactive protein (CRP), tumour necrosis factor alpha (TNF-α), soluble intercellular adhesion molecule (sICAM) [11] and plasminogen activator inhibitor-1 (PAI-1) [8,10], have been observed. We hypothesise that the use of a continuous MetS score better predicts the risks of inflammation, endothelial damage, and CVD compared with the use of the classic MetS definition.…”

Section: Introductionmentioning

confidence: 99%

A Continuous Metabolic Syndrome Score Is Associated with Specific Biomarkers of Inflammation and CVD Risk in Prepubertal Children

Olza

Aguilera

Gil-Campos³

et al. 2015

Ann Nutr Metab

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Background/Aims: We aimed to evaluate the use of a continuous metabolic syndrome (MetS) score and to assess the associations of this score with risk biomarkers of inflammation, endothelial damage and cardiovascular disease (CVD) in prepubertal children. Methods: A total of 677 prepubertal children (295 obese, 146 overweight, and 236 normal-weight) were recruited. MetS traits, markers of inflammation, endothelial damage and CVD risk were measured, and a continuous MetS score was calculated, consisting of the sum/5 of the standardised scores of the MetS components. Results: The continuous MetS score was significantly associated with active plasminogen activator inhibitor-1 (r = 0.406, p < 0.001), adiponectin (r = -0.212, p < 0.001), resistin (r = 0.263, p < 0.001), C-reactive protein (r = 0.254, p < 0.001), tumour necrosis factor alpha (r = 0.120, p = 0.003), myeloperoxidase (r = 0.188, p < 0.001) and sE-selectin (r = 0.278, p < 0.001). Children in the normal-weight, overweight and obese groups with MetS totalled 0 (0%), 1 (0.7%) and 24 (8.7%), respectively, whereas the at-risk children identified using the continuous MetS score in each group totalled 2 (0.85%), 17 (11.6%) and 167 (56.6%), respectively. Conclusions: The association of the continuous MetS score with specific risk biomarkers of inflammation, endothelial damage and CVD supports its use in the early identification of children at increased risk of metabolic dysfunction.

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“…The mean value of three tests was recorded. Normal levels were 4.73 ± 0.69 ng/mL 14 . Serum glucose was measured by enzymatic assay, and values between 60 and 100 mg/dL were considered normal according to the AAP 15 .…”

Section: Methodsmentioning

confidence: 96%

Carotid intima-media thickness and its correlation with anthropometric and clinical variables in pediatric patients with obesity: An exploratory study

Alba-Rojas¹,

Rodríguez-de-Ita²,

Yañez-Sánchez³

et al. 2019

RMU

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Aim: Mexico is currently ranked first in childhood obesity. Measurement of carotid intima-media thickness (cIMT) is an important diagnostic method to identify patients at risk of or already having frank atherosclerosis. The aim of this study was to determine if there was a correlation between cIMT and anthropometric and clinical variables in pediatric patients with obesity. Methods: Anthropometric and clinical variables were collected from 28 pediatric patients with obesity between 10 and 18 years old who underwent measurement of cIMT. cIMT was measured using a Doppler ultrasound with a 7 MHz transducer. All measurements were made with the same Philips HD (Mode B) ultrasound by the same pediatric cardiologist. Statistical analysis was performed using the Spearman correlation coefficient and linear regression. Results: There was a significant correlation between the cIMT and both body mass index (BMI) and triceps skinfold thickness, but not with leptin, fasting glucose, or cholesterol levels. cIMT was ≥ 0.40 mm in 24 (85%) patients. Pre-hypertension was found in 16 (57%) and hypertension in 4 (14%). Cholesterol levels > 200 mg/dL were found in 6 (21%). cIMT was positively correlated with weight (r s = 0.412, p = 0.030), BMI (coefficient r s of 0.452 and p = 0.016), and triceps skinfold (coefficient r s of 0.396 and p= 0.037). Conclusions: Anthropometric measurements, including BMI and triceps skinfold thickness, should be used in the evaluation of the cardiovascular risk of the pediatric population with obesity.

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Relationship between Changes in Plasma Leptin Concentrations and Plasminogen Activator Inhibitor-1 in Obese Prepubertal Children after Nine Months of Treatment

Cited by 6 publications

References 34 publications

Change in obesity‐related metabolic abnormalities associated with body mass index improvement through life‐style intervention: A meta‐regression

Change in obesity‐related metabolic abnormalities associated with body mass index improvement through life‐style intervention: A meta‐regression

A Continuous Metabolic Syndrome Score Is Associated with Specific Biomarkers of Inflammation and CVD Risk in Prepubertal Children

Carotid intima-media thickness and its correlation with anthropometric and clinical variables in pediatric patients with obesity: An exploratory study

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