Relationship between changes in dynamic hyperinflation and cardiovascular parameters during exercise in patients with COPD

Lukácsovits, József; Máthé, Csaba; Losonczy, György; Varga, János

doi:10.1183/13993003.congress-2019.pa1633

Cited by 1 publication

(3 citation statements)

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“…The patients were comfortably seated on the cardio-pulmonary exercise test device, and ECG monitoring, a blood pressure cuff, and a pulse oximeter sensor were used. The face mask in a perfectly fit position to face of the patients was placed [12]. The flow sensor of the respiratory mechanical unit was attached to the face mask and the finger cuff of the finometer was placed on the patient's right middle finger.…”

Section: Exercise Protocolmentioning

confidence: 99%

“…The exercise was ended at the maximal exercise tolerance of the patients. Each load level lasted for 2 minutes, and respiratory mechanics data were recorded during the last minute [12].…”

Section: Plos Onementioning

confidence: 99%

“…An IC manoeuvres were performed during each level of load to detect the presence of dynamic hyperinflation. The presence of dynamic hyperinflation was defined by a 5% and at least 100 ml decrease of IC at maximal load compared to rest [12].…”

Section: Plos Onementioning

confidence: 99%

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Cardiovascular effects of exercise induced dynamic hyperinflation in COPD patients—Dynamically hyperinflated and non-hyperinflated subgroups

2023

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Introduction An increase in respiratory rate and expiratory flow limitation can facilitate dynamic hyperinflation (DH), which may cause an element of the intrathoracic pressure in connection with the worsening of venous return, with negative effect on stroke volume (SV) and cardiac output (CO). It has been unclassified, whether poor circulatory adaptation to exercise can be attributed to DH or poor cardio-vascular performance itself in COPD. Only a subset of COPD patients exhibit dynamic hyperinflation during exercise. Patients and methods We designed a study to show how lung mechanical and cardiovascular parameters change in hyperinflated and non-hyperinflated COPD patients during exercise with a new experimental set-up. Thirty-three COPD patients with similar severity of COPD and left ventricular performance (20 men, 13 women, mean±SD age: 65,36±6,95 years) participated. We measured the cardiovascular parameters with a non-invasive device (Finometer-pro) including the left ventricular ejection time index (LVETi) and estimated the change of DH with inspiratory capacity (IC) manoeuvres during exercise. Results Twenty-one subjects exhibited DH (DH group) and 12 did not (non-DH group). The measurement results were given in mean ± SD and difference between the values measured during maximal load and rest also (ΔX = Xmax.load—Xrest). ΔSV and ΔCO were significantly higher in non-DH vs. DH patients (ΔSV: non-DH 9,7 ± 13,22 ml vs. DH -3,6 ± 14,34 ml, p = 0.0142; ΔCO: non-DH 2,26 ± 1,46 l/min vs. DH 0,88 ± 1,35 l/min, p = 0.0024). LVETi was not different between the two groups. Calculated oxygen delivery (DO2) during maximal load was significantly higher in non-DH group. Conclusion We concluded that worse cardiovascular adaptation to exercise of COPD patients can be associated with exercise-induced DH in a similar cardiovascular aged COPD group.

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Section: Exercise Protocolmentioning

confidence: 99%

“…The exercise was ended at the maximal exercise tolerance of the patients. Each load level lasted for 2 minutes, and respiratory mechanics data were recorded during the last minute [12].…”

Section: Plos Onementioning

confidence: 99%