Relationship Between Changes in Dietary Sucrose and High Density Lipoprotein Cholesterol

Archer, Sujata L.; Liu, Kiang; Dyer, Alan R.; Ruth, Karen; Jacobs, David R.; Horn, Linda Van; Hilner, Joan E.; Savage, Peter J.

doi:10.1016/s1047-2797(98)00007-6

Cited by 26 publications

(17 citation statements)

References 24 publications

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“…8,9 Data from the Coronary Artery Risk Development In young Adults (CARDIA) study show a consistent inverse association between increased dietary sucrose intake and HDL cholesterol concentrations, in both cross-sectional and longitudinal analyses in blacks and whites, in both men and women, and after adjustment for other covariates. 10 A diet high in sucrose (ie, Ͼ20% of energy) is associated with an elevation of plasma triglyceride concentrations. 11,12 This increase is due to both increased hepatic secretion and impaired clearance of very-low-density lipoprotein.…”

Section: Dietary Sugar and Plasma Lipoproteinsmentioning

confidence: 99%

Sugar and Cardiovascular Disease

Howard¹,

Wylie‐Rosett²

2002

Circulation

169

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Section: Dietary Sugar and Plasma Lipoproteinsmentioning

confidence: 99%

Sugar and Cardiovascular Disease

Howard¹,

Wylie‐Rosett²

2002

Circulation

169

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“…While inverse associations between intake of simple carbohydrates and measures of glycaemia and insulin resistance were observed in four of the larger cross-sectional studies (Keen et al 1979;Feskens & Kromhout, 1990;Buyken et al 2000;Williams et al 2000), five other cross-sectional (Mooy et al 1995;Boeing et al 2000;Rosell et al 2003;Yang et al 2003) and longitudinal (Marshall et al 1997) studies revealed no association. Aweak positive association between simple carbohydrate intake and fasting insulin levels was reported in the 'Coronary Artery Risk Development in Young Adults'study of young black and white Americans (Manolio et al 1991;Archer et al 1998). Similarly, in a study by Sevak et al (1994), which had the advantage of a 7 d weighed intake, total carbohydrate and sucrose intake was positively correlated with insulin resistance but only for postprandial and not fasting insulin measures (Sevak et al 1994).…”

Section: Epidemiological Studies Of Dietary Sugars Intakementioning

confidence: 83%

“…Similarly, in a study by Sevak et al (1994), which had the advantage of a 7 d weighed intake, total carbohydrate and sucrose intake was positively correlated with insulin resistance but only for postprandial and not fasting insulin measures (Sevak et al 1994). Interestingly, these latter studies that demonstrated a positive relationship between dietary sugars and insulin resistance involved South Asian adults in London and black American children (Manolio et al 1991;Archer et al 1998). Thus, when considering these studies, the possible influence of genetic factors, which may predispose to insulin resistance, should not be overlooked as illustrated by the impact of 'thrifty' insulin resistance genes in South Asian (Lindquist et al 2000) and Westernised Native American Pima Indian populations (Weyer et al 1999).…”

Section: Epidemiological Studies Of Dietary Sugars Intakementioning

confidence: 99%

Determining the relationship between dietary carbohydrate intake and insulin resistance

McClenaghan

2005

Nutr. Res. Rev.

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Insulin resistance underlies type 2 diabetes, CVD and the metabolic syndrome, driven by changes in diet, lifestyle, energy over-consumption and obesity. Nutritional recommendations for insulin resistance remain an area of controversy, particularly the quantity and types of dietary carbohydrate. The present review gives an overview of insulin resistance, its relationship to impaired insulin secretion and the metabolic syndrome, research methodologies used to measure insulin action and the epidemiological and intervention studies on the relationship between dietary carbohydrate and insulin resistance. Epidemiological studies provide little evidence to suggest that total dietary carbohydrate predicts risk of type 2 diabetes, and high-carbohydrate, high-fibre diets with low-glycaemic index (GI) may even contribute to diabetes prevention. Despite inherent limitations associated with techniques used to measure insulin resistance and dietary assessment, most intervention studies reveal an increase in glucose tolerance or insulin sensitivity with highcarbohydrate, low-fat diets in non-diabetic and diabetic individuals. When energy is restricted the source or reduced content of carbohydrate does not appear to be as important as fat for body weight. Thus, low energy intake is key to weight loss and augmentation of insulin sensitivity. Given this, widespread adoption of popular low-carbohydrate high-fat diets highlights the necessity to evaluate dietary interventions regarding safety and metabolic effects. While current evidence supports FAO/WHO recommendations to maintain a highcarbohydrate diet with low-GI foods, the relationships between carbohydrate and insulin sensitivity remains an important research area. Emerging technologies should further enhance understanding of gene -diet interactions in insulin resistance, providing useful information for future nutrition policy decisions.

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“…This disaccharide may increase the serum TG concentration and lower the serum HDL (Høstmark and Blom 1985;Archer et al 1998). Dhingra et al (2007) found a positive association between soft drink intake and serum TG, and a negative relationship between soft drink intake and HDL.…”

Section: Possible Explanations For the Findingsmentioning

confidence: 96%

Cola intake and serum lipids in the Oslo Health Study

Høstmark

Tomten

2009

Appl. Physiol. Nutr. Metab.

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Soft drinks can be a major source of sucrose, which may influence serum lipid concentration. We have examined the association between intake frequency of various types of soft drinks and the concentration of serum triglycerides (TG) and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol in the cross-sectional Oslo Health Study. A total of 14 188 subjects of the altogether 18 770 participants of the study had data on intake frequency of colas and non-colas, with or without sugar. The population sample consisted of both sexes and 3 age groups: group1 (30 years of age), group 2 (40 and 45 years of age), and group 3 (59-60 years of age). In both sexes, HDL decreased and TG increased significantly (p < 0.001) with increasing intake frequency of colas. In contrast, no consistent associations were found between the reported intake of non-cola soft drinks and the serum lipids. We found no significant differences related to the reported presence or absence of sugar in the soft drinks. In multiple linear regression analyses, the colas vs. serum lipid associations prevailed (p < 0.001) after including 13 possible confounders: sex; age group; time since last meal; physical activity; intake of alcohol, coffee, cheese, fruit and (or) berries, and fatty fish; smoking; length of education; use of cholesterol-lowering drugs; and intake of non-colas. Thus, the self-reported intake frequency of colas, but not other soft drinks, was negatively associated with serum HDL, and positively associated with TG and LDL.Key words: HDL cholesterol, LDL cholesterol, triglycerides, serum, cola, carbonated soft drinks, men, women, cross-sectional study.Résumé : Les boissons gazeuses représentent probablement une des plus importantes sources de sucrose pouvant modifier la concentration sérique des lipides. Cet article présente la relation entre la fréquence de la consommation de diverses boissons et la concentration sérique des triglycérides (TG), de cholestérol HDL et de cholestérol LDL dans l'Enquête transversale sur la santé d'Oslo. Des 18 770 participants, 14 188 sujets fournissent des données concernant la fréquence de consommation de boissons à base ou non de cola, avec ou sans sucre. On retrouve dans l'échantillon trois groupes d'âge des deux genres : groupe 1, 30 ans, groupe 2, 40 et 45 ans, groupe 3, 59-60 ans. Chez les femmes et les hommes, la concentration de cholestérol HDL diminue significativement et celle des TG augmente significativement (p < 0,001) avec l'augmentation de la consommation de colas. En revanche, on n'observe pas de relation entre la consommation rapportée de boissons sans cola et la concentration sérique de lipides. On n'observe aucune différence significative en ce qui concerne la présence ou l'absence rapportée de sucres dans les boissons gazeuses. Les analyses de régression multiple ré-vèlent la relation (p < 0,001) entre la présence de cola et la concentration sérique de lipides même après l'inclusion de variables parasites : genre, groupe d'âge, moment depuis le dernier repa...

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Relationship Between Changes in Dietary Sucrose and High Density Lipoprotein Cholesterol

Cited by 26 publications

References 24 publications

Sugar and Cardiovascular Disease

Sugar and Cardiovascular Disease

Determining the relationship between dietary carbohydrate intake and insulin resistance

Cola intake and serum lipids in the Oslo Health Study

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