Relationship Between Cerebrospinal Fluid and Blood Dynamics in Healthy Volunteers and Patients with Communicating Hydrocephalus

Balédent, Olivier; Gondry-Jouet, Catherine; Meyer, Marc-Étienne; Marco, Giovanni de; Gars, D. Le; Henry–Feugeas, Marie-Cécile; Idy-Peretti, I.

doi:10.1097/01.rli.0000100892.87214.49

Cited by 166 publications

(182 citation statements)

References 28 publications

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“…5 However, the principal driving forces of CSF pulsation and the transmission mechanism of the force from the blood vessels or brain parenchyma are not fully understood. Evaluation of normal CSF circulation in terms of peak velocity, flow rate, and flow velocity waveform in conjunction with evaluation of spatial blood flow may provide a useful knowledge base for diagnosing patients with disorders of CSF dynamics, such as hydrocephalus, 6,7 Chiari I malformation, 8,9 and arachnoid cysts.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

et al. 2015

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Purpose: We compared the depiction of pulsatile CSF motion obtained by 4-dimensional phase-contrast velocity mapping (4D-VM) with that by time-spatial labeling inversion pulse (time-SLIP) technique in the presence of membrane structures.Materials and Methods: We compared the 2 techniques using a flow phantom comprising tubes with and without a thin rubber membrane and applied the techniques to 6 healthy volunteers and 2 patients to analyze CSF dynamics surrounding thin membrane structures, such as the Liliequist membrane (LM), or the wall of an arachnoid cyst.Results: Phantom images exhibited propagation of the flow and pressure gradient beyond the membrane in the tube. In contrast, fluid labeled by the time-SLIP technique showed little displacement from the blockage of spin travelling by the membrane. A similar phenomenon was observed around the LM in healthy volunteers and the arachnoid cyst wall in a patient.Conclusion: Four-dimensional phase-contrast velocity mapping permitted visualization of the propagation of CSF pulsation through the intracranial membranous structures. This suggests that 4D-VM and the time-SLIP technique provide different information on flow and that both techniques are useful for classifying the pathophysiological status of CSF and elucidating the propagation pathway of CSF pulsation in the cranium.

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Section: Introductionmentioning

confidence: 99%

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

et al. 2015

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“…If so, then corresponding secondary abnormalities in the flow of CSF through the cerebral aqueduct (earlier onset and reduced duration of the systolic CSF flow peak) should be observable by MRI. In previous studies, phase-contrast (PC) MRI measurement of blood and CSF flow was used to investigate the mechanical properties of brain parenchyma (21,22) and to detect variations in flow due to communicating hydrocephalus (23,24). If such changes are detectable in patients with MVA, they could provide a valuable quantitative biomarker of the severity of MVA, which would be of particular use in the development and testing of novel therapeutic agents that target the cerebral vasculature.…”

mentioning

confidence: 99%

Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment‐resistant late‐life depression: A potential biomarker of microvascular angiopathy

Naish

Baldwin

Patankar

et al. 2006

Magnetic Resonance in Med

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“…For example, Greitz 15 found, along with an increased aqueductal flow rate, a corresponding decreased flow rate through the craniocervical junction. Balédent et al, 12 in a larger study, found no such changes. To use stroke volume to diagnose hyperdynamic CSF, a measurement that some investigators have advocated for diagnosing shunt-responsive NPH, 19 one must first determine a baseline stroke volume in healthy elderly patients.…”

Section: Quantitative Measurements From Pcmentioning

confidence: 77%

“…One such study revealed a shorter systolic flow period of the temporal waveform for patients with communicating hydrocephalus compared with healthy controls. 12 PC measurements of CSF flow have also been used to study patients with Chiari I malformation. In these studies, the CSF flow at the craniocervical junction has been shown to exhibit changes in flow patterns, including local flow jets and bidirectional flow.…”

Section: Quantitative Measurements From Pcmentioning

confidence: 99%

Current and Emerging MR Imaging Techniques for the Diagnosis and Management of CSF Flow Disorders: A Review of Phase-Contrast and Time–Spatial Labeling Inversion Pulse

Yamada

Tsuchiya

Bradley

et al. 2014

AJNR Am J Neuroradiol

118

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SUMMARY:This article provides an overview of phase-contrast and time-spatial labeling inversion pulse MR imaging techniques to assess CSF movement in the CNS under normal and pathophysiologic situations. Phase-contrast can quantitatively measure stroke volume in selected regions, notably the aqueduct of Sylvius, synchronized to the heartbeat. Judicious fine-tuning of the technique is needed to achieve maximal temporal resolution, and it has limited visualization of CSF motion in many CNS regions. Phase-contrast is frequently used to evaluate those patients with suspected normal pressure hydrocephalus and a Chiari I malformation. Correlation with successful treatment outcome has been problematic. Time-spatial labeling inversion pulse, with a high signal-to-noise ratio, assesses linear and turbulent motion of CSF anywhere in the CNS. Time-spatial labeling inversion pulse can qualitatively visualize whether CSF flows between 2 compartments and determine whether there is flow through the aqueduct of Sylvius or a new surgically created stoma. Cine images reveal CSF linear and turbulent flow patterns. ABBREVIATIONS:CSP ϭ cavum septi pellucidi; NPH ϭ normal pressure hydrocephalus; PC ϭ phase-contrast; Time-SLIP ϭ time-spatial labeling inversion pulse;

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Relationship Between Cerebrospinal Fluid and Blood Dynamics in Healthy Volunteers and Patients with Communicating Hydrocephalus

Abstract: Venous vessel compression and/or changes in intracranial subarachnoid CSF flow produce an increase in ventricular CSF flush that compensates for vascular brain expansion in patients with CH.

Cited by 166 publications

References 28 publications

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment‐resistant late‐life depression: A potential biomarker of microvascular angiopathy

Current and Emerging MR Imaging Techniques for the Diagnosis and Management of CSF Flow Disorders: A Review of Phase-Contrast and Time–Spatial Labeling Inversion Pulse

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