Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis

Sargazi, Saman; Abghari, Armin Zahedi; Sarani, Hosna; Sheervalilou, Roghayeh; Mirinejad, Shekoufeh; Eskandari, Ebrahim

doi:10.1007/s12010-021-03613-w

Cited by 7 publications

(7 citation statements)

References 70 publications

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“…As a key protease, CASP8 participates in the transmission of exogenous apoptosis signals in mammals, and CASP9 plays a crucial role in the mitochondria-mediated endogenous apoptosis pathway[ 27 ]. CASP3 plays a central role as a key protease in apoptosis and is also known as the “death protease”, and the cascade reaction of apoptosis continues after the action of this enzyme[ 28 ]. Immune factors, including helper T cells, regulatory T cells, cytokines and autoantibodies, play an important role in the pathogenesis and progression of IBD[ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

Ji¹,

Dai²,

Wen³

et al. 2022

WJCC

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BACKGROUND Inflammatory bowel disease (IBD) is a complex chronic IBD that is closely associated with risk factors such as environment, diet, medications and lifestyle that may influence the host microbiome or immune response to antigens. At present, with the increasing incidence of IBD worldwide, it is of great significance to further study the pathogenesis of IBD and seek new therapeutic targets. Traditional Chinese medicine (TCM) treatment of diseases is characterized by multiple approaches and multiple targets and has a long history of clinical application in China. The mechanism underlying the effect of zedoary turmeric-trisomes on inducing mucosal healing in IBD is not clear. AIM To explore the effective components and potential mechanism of zedoary turmeric-trisomes in the treatment of IBD with intestinal fibrosis using network pharmacology and molecular docking techniques. METHODS The chemical constituents and targets of Rhizoma zedoary and Rhizoma sanarum were screened using the TCMSP database. The GeneCards database was searched to identify targets associated with intestinal fibrosis in IBD. The intersection of chemical component targets and disease targets was obtained using the Venny 2.1 online analysis platform, and the common targets were imported into the STRING 11.0 database to construct a protein interaction regulatory network. A “zedoary turmeric-trisomes-chemical composition-target-disease” network diagram was subsequently constructed using Cytoscape 3.7.2 software, and the topological properties of the network were analyzed using the “Network Analysis” plug-in. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of the common targets were performed using the DAVID 6.8 database to elucidate the mechanism of zedoary turmeric-trisomes in the treatment of IBD. Subsequently, molecular docking of the compounds and targets with the highest intermediate values in the “zedoary turmeric-trisomes-chemical composition-target-disease” network was performed using Sybyl-x 2.1.1 software. RESULTS A total of 5 chemical components with 60 targets were identified, as well as 3153 targets related to IBD and 44 common targets. The protein-protein interaction network showed that the core therapeutic targets included JUN, MAPK14, CASP3, AR, and PTGS2. The GO enrichment analysis identified 759 items, and the KEGG enrichment analysis yielded 52 items, including the cancer pathway, neuroactive ligand-receptor interaction, hepatitis B, and the calcium signaling pathway, reflecting the complex biological processes of the multicomponent, multitarget and multipathway treatment of diseases with zedoary turmeric-trisomes. Molecular docking showed that the compound bonded with the target through hydrogen bond interactions and exhibited good docking activity. CONCLUSION This study identified the potential m...

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Section: Discussionmentioning

confidence: 99%

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

Ji¹,

Dai²,

Wen³

et al. 2022

WJCC

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“…Sargazi's experiments demonstrated that CASP9 rs4645981 and rs1052571 polymorphisms are associated with overall cancer risk (Sargazi et al, 2021). What's more, miR-182-5p inhibition can reduce the viability of MCF-7 (human breast cancer cell line) cells because of apoptosis induction, probably through the upregulation of CASP9 (Sharifi and Moridnia, 2017).…”

Section: Samanmentioning

confidence: 99%

The signature of pyroptosis-related gene prognostic and immune microenvironment in adrenocortical carcinoma

Gao

Wang²,

Yang³

et al. 2023

Front. Mol. Biosci.

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Adrenocortical carcinoma (ACC) has a low incidence but a poor prognosis. And ACC has complex clinical manifestations and limited treatment. Pyroptosis has a dual character and has both positive and negative effects on cancer. However, the role of pyroptosis-related genes (PRGs) in ACC and the impact on ACC progression remains unelucidated. This study performed systematic bioinformatics analysis and basic experimental validation to enable the establishment of prognostic models and demonstrate levels of immune infiltration. Pearson’s correlation analysis was used to assess the association of PRGs with tumor immune infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), and immune checkpoints. There 4 PRGs were upregulated, and 25 PRGs were downregulated in ACC. At the same time, we analyzed and reviewed the genetic mutation variation landscape of PRGs. Functional enrichment analysis was also performed to clarify the function of PRGs. Pyroptosis, the inflammatory response, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway are the functions and pathways mainly involved and exerted effects by these 33 PRGs. The results of the prognosis analysis revealed high expression of CASP3, CASP9, GSDMB, GSDMD, NLRC4, PRKACA, and SCAF11 caused a poor survival rate for ACC patients. The above seven PRGs were screened by the optimal λ value of LASSO Cox analysis, and the five selected genes (CASP3, CASP9, GSDMB, GSDMD, NLRC4) were involved in constructing a prognostic PRGs model which enables the overall survival in ACC patients can be predicted with moderate to high accuracy. Prognostic PRGs, especially CASP9, which is the independent factor of ACC prognosis, may be closely correlated with immune-cell infiltration, tumor mutation burden, microsatellite instability, and immune checkpoints. Quantitative Real-Time PCR (qRT-PCR), Western blot and immunohistochemical were performed to validate the mRNA expression levels of CASP9 in adjacent normal tissues and ACC tissues. According to the result of immune checkpoints analysis, NLRC4 and GSDMB may be identified as potential therapeutic targets. In conclusion, we established a prognostic model of PRG characteristics in ACC and analyzed the relationship between PRGs and immune infiltration. Through our study, it may be helpful to find the mechanism of pyroptosis in ACC.

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“…Taken together, according to the meta-analysis study, multiple SNPs are already associated with various kinds of cancer. 29 The association between the lncRNA HOTAIR rs1899663 and rs2366152 and CRC has not been studied in the Iranian population yet. As a result, our case-control study sought to assess the association between the lncRNA HOTAIR rs2366152 and rs1899663 polymorphisms and CRC susceptibility in Iranian population.…”

Section: Introductionmentioning

confidence: 99%

“…Sharma Saha et al 28 have shown the C allele of rs2366152 is prevalent among cervical cancer cases that lead to low HOTAIR expression. Taken together, according to the meta‐analysis study, multiple SNPs are already associated with various kinds of cancer 29 …”

Section: Introductionmentioning

confidence: 99%

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Association of HOTAIR rs2366152 and rs1899663 polymorphisms with colorectal cancer susceptibility in Iranian population: A case–control study

Eivazi,

Mirfakhraie,

Nazemalhosseini Mojarad

et al. 2023

Clinical Laboratory Analysis

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Background Despite the fact that numerous studies have investigated the association between genetic polymorphisms and colorectal cancer (CRC), more research is required to comprehend the molecular mechanisms of CRC. In the present study, we investigated the association between lncRNA HOTAIR rs2366152 and rs1899663 polymorphisms with CRC susceptibility in the Iranian population. Methods This case–control study consisting of 187 CRC patients and 200 healthy samples. The tetra‐amplification refractory mutation system‐polymerase chain reaction (Tetra‐ARMS‐PCR) technique was used for the genotyping of rs2366152 and rs1899663 polymorphisms. Results The findings showed that the AG genotype of the rs2366152 polymorphism has a protective effect on CRC susceptibility (OR = 0.60, 95% CI: 0.38–0.94, p‐value = 0.023). Furthermore, rs2366152 polymorphism associated with CRC risk in an over dominant inheritance model (p‐value = 0.0089). According to the outcomes of the rs1899663 polymorphism, the GT genotype had protective effects on CRC risk (OR = 0.55, 95% CI: 0.35–0.86, p‐value = 0.008). Moreover, statistical analysis has shown that the rs1899663 polymorphism was associated with CRC risk in dominant (p‐value = 0.013) and overdominant (p‐value = 0.0086) inheritance models in the Iranian population. Conclusion This study confirmed that HOTAIR rs2366152 and rs1899663 polymorphisms associated with CRC risk in different inheritance models. It is indeed necessary to do additional research to verify our findings.

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Relationship Between CASP9 and CASP10 Gene Polymorphisms and Cancer Susceptibility: Evidence from an Updated Meta-analysis

Cited by 7 publications

References 70 publications

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

Network pharmacology and molecular docking reveal zedoary turmeric-trisomes in Inflammatory bowel disease with intestinal fibrosis

The signature of pyroptosis-related gene prognostic and immune microenvironment in adrenocortical carcinoma

Association of HOTAIR rs2366152 and rs1899663 polymorphisms with colorectal cancer susceptibility in Iranian population: A case–control study

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