Relationship Between CarotidIntima-Media Thickness and Silent Cerebral Infarction in Japanese Subjects With Type 2 Diabetes

Abstract

OBJECTIVEWe examined the relationship between intima-media thickness of common carotid artery (CCA-IMT) and silent cerebral infarction (SCI) with the magnetic resonance imaging (MRI) study in Japanese subjects with type 2 diabetes.RESEARCH DESIGN AND METHODSThe brain MRI study and the carotid ultrasonography were performed in a total of 217 consecutive Japanese subjects with type 2 diabetes. Various risk factors for SCI were examined using multiple logistic analyses.RESULTSThe SCI was found in 60.4% of the diabetic subjects. In the diabetic subjects, age, systolic blood pressure (SBP), pulse wave velocity, and CCA-IMT were significantly higher in the subjects with SCI than in those without it. Multiple logistic analyses indicated that age, SBP, and CCA-IMT were significant and independent risk factors of SCI in the diabetic subjects.CONCLUSIONSCCA-IMT, but not pulse wave velocity, was independently associated with SCI in Japanese subjects with type 2 diabetes.

Association between Silent Brain Infarct and Arterial Stiffness Indicated by Brachial-ankle Pulse Wave Velocity

“…Increased CCAIMT is a surrogate marker for atherosclerosis and SBI, and is a risk for stroke (29,30). Although CCAIMT was not significantly associated with SBI in the present study, the combination of baPWV!17.49 m/s and CCAIMT!1.1 mm strongly indicated the presence of SBI.…”

“…In our study, because SBI required a diameter!3 mm, état cribIé was excluded. Nomura et al reported that CCAIMT, but not baPWV (by 1 cm/s) was independently associated with SBI in patients with diabetes mellitus (30). However, change the unit of pulse wave velocity (PWV) from cm/s to m/s might be better to identify the relationship of PWV with outcomes and to simplify determination of the cutoff values of PWV (4,27).…”

Duplex color doppler evaluation of carotid atherosclerosis in patient with silent cerebral infarction detected by MRI

“…[3][4][5][12][13][14][15]21 age, hypertension and plaque score strongly and independently correlated with the occurrence of SCI of brain, compatible with results of other studies. 22,23,24 Conclusion Silent cerebral infarction (SCI) detected incidentally by MRI is considered the preliminary stage of accidental stroke and assumed to be secondary to atherosclerotic vascular disease (ASVD). Investigating its clinicopathology may elucidate the underlying mechanism of stroke onset and help to prevent this disabling disease.…”

Chitotriosidase Enzyme Activity and miRNA-146a expression and their value as potential Biomarkers of subclinical Atherosclerosis in type 2 Diabetes Mellitus

“…In addition, they can directly stimulate or inhibit target gene transcription by directly binding to promoter regions, RNAactivation phenomena. miR-146a is involved in modulation of the inflammatory pathways in T2DM [6] Measurement of the carotid intima-media thickness (CIMT) has been recognized as a powerful method for identifying subclinical atherosclerosis, and increased thickness of the intima-media complex reflects local generalized atherosclerosis [7] .The objective of this study was to evaluate respective values of miRNA-146a and CHIT1andtheir association with CIMT, being a valid marker of atherosclerosis in T2DM patients.…”