Relationship Between Cardiovascular Risk as Predicted by Established Risk Scores Versus Plaque Progression as Measured by Serial Intravascular Ultrasound in Left Main Coronary Arteries

Birgelen, Clemens von; Hartmann, Marc; Mintz, Gary S.; Houwelingen, K. Gert van; Deppermann, Nadine; Schmermund, Axel; Böse, Dirk; Eggebrecht, Holger; Neumann, Till; Gössl, Mario; Wieneke, Heinrich; Erbel, Raimund

doi:10.1161/01.cir.0000142048.94084.ca

Cited by 137 publications

(86 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study of 107 patients with angiographically insignificant coronary atherosclerosis, left main coronary artery disease detected by IVUS was significantly associated with future coronary events 63 . IVUS studies have shown that the rate of plaque growth in the left main coronary artery correlates with traditional risk factors 64,65 . Patients at greatest risk of cardiovascular events, as determined by the PROCAM, SCORE, and Framingham CVD algorithms, exhibited significantly greater plaque progression between baseline and follow-up (median 14 months).…”

Section: Intravascular Ultrasoundmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

SummaryCAD remains a major global cause of morbidity and mortality. Comprehensive drug development programs of novel pharmacological treatment strategies frequently utilize traditional mortality/morbidity endpoints studies and additional surrogate endpoints trials. This parallel approach allows an assessment of efficacy several years in advance of the availability of data from clinical endpoint trials. Several atherosclerosis imaging markers have been introduced into these drug-development strategies, including angiography, carotid ultrasound, IVUS, MRI, and CT. This review will discuss the current status of atherosclerosis imaging as an endpoint in progression/regression trials, with an emphasis on evidence-based data. In addition to a discussion of the results of individual imaging modalities, the emerging data comparing different modalities and approaches are presented.

show abstract

Section: Intravascular Ultrasoundmentioning

confidence: 99%

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Schoenhagen¹,

Tuzcu²

2008

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…To date, quantitative studies of human coronary atherosclerosis in patients with diabetes have provided conflicting information [2][3][4][5]. Also, while individuals with impaired fasting glucose (IFG) tolerance have an increased cardiovascular risk [6], the severity and progression of coronary atherosclerosis in this group have not been compared with that in patients with and without diabetes.…”

Section: Introductionmentioning

confidence: 99%

Glycaemic status influences the nature and severity of coronary artery disease

et al. 2010

View full text Add to dashboard Cite

Aims/hypothesis We sought to understand the relationships between glycaemic status and both severity and progression of coronary artery disease (CAD), the leading cause of death in diabetes. Methods Baseline fasting blood glucose (FBG) and HbA 1c (%) were measured in 426 patients with known or suspected stable CAD, who underwent coronary artery intravascular ultrasound (IVUS) at baseline and after a mean follow-up period of 664 days (range 257 to 961). The patients were categorised as normoglycaemic (n=226, 53%), or as having impaired fasting glucose (n=118, 28%) or diabetes (n=82, 19%). Results The maximum percentage coronary atheroma area at baseline was greater in diabetic patients (73.33±8.86%) than in those with normoglycaemia (69.08±10.43%; p=0.001) and impaired fasting glucose (69.32±9.59%; p=0.0031). In averaged IVUS measurements of the 30-mm target segment (n=332 participants), change in percentage atheroma area during follow-up was also greater in the diabetes (1.86± 3.90%) than in other groups (0.28±3.32% and 0.56±2.96%, p=0.0047 global). FBG correlated with maximum percentage atheroma area at baseline (r=0.17; p=0.0003). HbA 1c also correlated with maximum percentage atheroma area at baseline (r=0.26; p=0.0001) and with change in maximum plaque area (r=0.16; p=0.016). A similar pattern of results occurred with plaque volume. The relationships between diabetes or HbA 1c and both IVUS measurements of plaque burden and remodelling persisted after adjustment. Conclusions/interpretation Fasting blood glucose, HbA 1c and the presence of diabetes are associated with the severity and progression of coronary atherosclerosis. These observations support the hypothesis that better glycaemic control may favourably influence CAD in patients with abnormal glucose tolerance or diabetes.

show abstract

“…In the absence of a validated risk score for secondary prevention, established primary-event risk scores have already been used to assess the relations between predicted cardiovascular risk and (1) the extent of plaque progression as assessed with serial intravascular ultrasound [29], and (2) the extent of coronary calcifications in patients with a first MI [30]. Notably, in the latter study by Pohle et al, which also investigated patients with a first MI, the estimated 10-year event risk as calculated by the Framingham Risk Score (14.3 ± 4.4%) was similar to that of our study (14.1 ± 5.8% ((i.e.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Framingham Risk Score and Left Ventricular Remodeling after Successful Primary Percutaneous Coronary Intervention in Patients with First Myocardial Infarction and Single Vessel Disease

Olimulder¹

2013

J Clin Exp Cardiolog

View full text Add to dashboard Cite

Relationship Between Cardiovascular Risk as Predicted by Established Risk Scores Versus Plaque Progression as Measured by Serial Intravascular Ultrasound in Left Main Coronary Arteries

Cited by 137 publications

References 23 publications

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Métodos por imagem da aterosclerose em estudos de progressão/regressão: marcador substituto ou janela direta para o processo patológico da aterosclerose?

Glycaemic status influences the nature and severity of coronary artery disease

Relationship between Framingham Risk Score and Left Ventricular Remodeling after Successful Primary Percutaneous Coronary Intervention in Patients with First Myocardial Infarction and Single Vessel Disease

Contact Info

Product

Resources

About