Relationship between cardiopulmonary mortality and cancer risk and quantitative exposure to polycyclic aromatic hydrocarbons, fluorides, and dust in two prebake aluminum smelters

Friesen, Melissa C.; Benke, Geza; Monaco, Anthony Del; Dennekamp, Martine; Fritschi, Lin; Klerk, Nicholas de; Hoving, Jan L.; MacFarlane, Ewan; Sim, Malcolm Ross

doi:10.1007/s10552-009-9329-8

Cited by 32 publications

(13 citation statements)

References 35 publications

(65 reference statements)

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“…Epidemiological findings support an association between the exposure of B[a]P or PAHs and the incidence of lung cancer, colon cancer, and skin cancer (Friesen et al 2009; Gunter et al 2007; Tang et al 1995). B[a]P does not cause cancers until it is metabolized to toxic metabolites by cytochrome P450 enzymes (Rivedal and Sanner 1981; Rubin 2001).…”

Section: Discussionmentioning

confidence: 95%

Effects of Benzo[ a ]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF- κ B Signaling

Li²,

Huang³

et al. 2015

Environ Health Perspect

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BackgroundBenzo[a]pyrene (B[a]P) is a common environmental and foodborne pollutant. Although the carcinogenicity of high-dose B[a]P has been extensively reported, the effects of long-term B[a]P exposure at lower environmental doses on cancer development are less understood.ObjectivesWe investigated the impact of B[a]P on human hepatocellular carcinoma (HCC) progression at various levels of exposure and identified a potential intervention target.MethodsWe used a model based on human HCC cells exposed to various concentrations of B[a]P (i.e., 0.01, 1, or 100 nM) for 1 month to examine the effects of B[a]P on cell growth, migration, invasion, and angiogenicity. A bioluminescent murine model was established to assess tumor metastasis in vivo.ResultsChronic B[a]P exposure did not alter HCC cell growth but promoted cell migration and invasion both in vitro and in vivo. There was an negative association between B[a]P exposure and the survival of tumor-bearing mice. In addition, B[a]P-treated HCC cells recruited vascular endothelial cells and promoted tumor angiogenesis, possibly through elevating vascular endothelial growth factor secretion. Furthermore, the NF-κB pathway may be an adverse outcome pathway associated with the cumulative effects of B[a]P on HCC metastasis.ConclusionsThese findings a) indicate that B[a]P has effects on HCC progression; b) identify a possible adverse outcome pathway; and c) contribute to a better understanding of the adverse effects of chronic exposure of B[a]P to human health.CitationBa Q, Li J, Huang C, Qiu H, Li J, Chu R, Zhang W, Xie D, Wu Y, Wang H. 2015. Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling. Environ Health Perspect 123:246–254; http://dx.doi.org/10.1289/ehp.1408524

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Section: Discussionmentioning

confidence: 95%

Effects of Benzo[ a ]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF- κ B Signaling

Li²,

Huang³

et al. 2015

Environ Health Perspect

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“…The smoking-adjusted relationship between mortality and cancer incidence in these same two prebake plants and benzene-soluble fraction (called benzene-soluble materials [BSM] in other studies), B(a)P, fluoride, and inhalable dust showed monotonic relationships between respiratory cancer and cumulative inhalable dust, cumulative fluoride exposure and cumulative B(a)P exposure, none statistically significant 38. They also reported a monotonic nonstatistically significant trend for stomach cancer, but bladder cancer was not associated with either B(a)P or benzene-soluble fraction.…”

Section: World Experiencementioning

confidence: 99%

Cancer Risks in Aluminum Reduction Plant Workers

Gibbs

2014

Journal of Occupational &Amp; Environmental Medicine

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Objective and Methods:This review examines epidemiological evidence relating to cancers in the primary aluminum industry where most of what is known relates to Söderberg operations or to mixed Söderberg/prebake operations.Results and Conclusions:Increased lung and bladder cancer risks have been reported in Söderberg workers from several countries, but not in all. After adjustment for smoking, these cancer risks still increase with cumulative exposure to benzo(a)pyrene, used as an index of coal tar pitch volatiles exposure. Limited evidence has been gathered in several cohorts for an increased risk of tumors at other sites, including stomach, pancreas, rectum/rectosigmoid junction, larynx, buccal cavity/pharynx, kidney, brain/nervous system, prostate, and lymphatic/hematopoietic tissues (in particular non-Hodgkin lymphoma, Hodgkin disease, and leukemia). Nevertheless, for most of these tumor sites, the relationship with specific exposures has not been demonstrated clearly and further follow-up of workers is warranted.

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“…PM 2.5 ) pollution that results from aluminum smelting. Similar results were found among aluminum workers in Australia with respect to cancer mortality from exposure to aluminum smelter benzene-compound pollution (Friesen et al, 2009; for other health issues see Noth et al, 2104; for relative health risk estimates for aluminum smelter workers see Wang et al, 2013). Costello et al (2014) found elevated rates of cancer and heart disease respectively among aluminum smelter workers in the automobile industry.…”

Section: Health Effects For Humans Animals and Plantsmentioning

confidence: 66%

Green Criminology and Social Justice: A Reexamination of the Lynemouth Plant Closing and the Political Economic Causes of Environmental and Social Injustice

Lynch

2015

Critical Sociology

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Pamela Ann Davies argues that the closure of the Lynemouth, UK, aluminum smelter generated adverse social justice impacts and was caused by the adoption of green state policies. She employs that argument to critique green criminology for promoting adverse social justice impacts. Here, we reanalyze the Lynemouth plant closure. First, this reanalysis illustrates the various social and environmental forms of injustice the plant generated, especially its adverse human, nonhuman and ecological health consequences. Second, the closure is reassessed from a political economic perspective that places the plant closure within the context of global capitalist plant closures in the aluminum industry. That review notes that plant closures and deindustrialization in developed economies are now a common occurrence driven by economic concerns, not environmental policies. We point out that social injustice as well as ecological destruction are often created by the normal operation of capitalism, and that those consequences should not be overlooked.

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Relationship between cardiopulmonary mortality and cancer risk and quantitative exposure to polycyclic aromatic hydrocarbons, fluorides, and dust in two prebake aluminum smelters

Cited by 32 publications

References 35 publications

Effects of Benzo[ a ]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF- κ B Signaling

Effects of Benzo[ a ]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF- κ B Signaling

Cancer Risks in Aluminum Reduction Plant Workers

Green Criminology and Social Justice: A Reexamination of the Lynemouth Plant Closing and the Political Economic Causes of Environmental and Social Injustice

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