Relationship between cardio-ankle vascular index (CAVI) and coronary artery calcification (CAC) in patients with type 2 diabetes mellitus

Abstract

Early detection of atherosclerosis is important for patients with type 2 diabetes mellitus because cardiovascular disease (CVD) is a main cause of death in these people. In this study, we investigated the relationship between an arterial stiffness parameter called cardio-ankle vascular index (CAVI) and coronary artery calcification (CAC). We performed a cross-sectional study in 371 type 2 diabetic patients with clinical suspicion of coronary heart disease (CHD). We evaluated the relationships between CAVI and CAC score determined by multislice computed tomography as well as major cardiovascular risk factors, including age, body mass index, hemoglobinA1c and the Framingham CHD risk score. CAVI was correlated with age (r = 0.301, p < 0.0001), uric acid (r = 0.236, p < 0.0001), estimated glomerular filtration rate (r = -0.145, p = 0.0166), CHD risk score (r = 0.327, p < 0.0001) and log (CAC + 1) (r = 0.303, p < 0.0001). The area under the receiver operating characteristic curve for CAVI was higher than that of CHD risk score in predicting CAC >0, CAC >100, CAC >400, or CAC >1000. CAVI is positively correlated with CAC, and is considered to be a useful method to detect CAC.

Coronary Artery Calcium Score Compared with Cardio-Ankle Vascular Index in the Prediction of Cardiovascular Events in Asymptomatic Patients with Type 2 Diabetes

“…The study result suggested that coronary artery calcification was an independent predictor of mortality in diabetes independent of diabetes duration and control and conventional cardiovascular risk factors. In another cross-sectional study with 371 patients with type 2 diabetes, CAVI was also correlated with age and log (CACS 1) 29) but not fasting plasma glucose and hemoglobin A1c. Our findings were consistent with these studies.…”

“…CAVI is easy to measure, unaffected by blood pressure, and superior in reproducibility compared with pulse wave velocity. Several reports have shown that CAVI is associated with atherosclerotic disease 23,[25][26][27][28] , which is also considered to be a useful method to detect coronary artery calcification 29) . CAVI may be more cost effective compared with CAC score.…”

“…CAVI is an arterial stiffness parameter [21][22][23][24] , which is easy to measure, unaffected by blood pressure, and superior in reproducibility compared with pulse wave velocity. Several reports have shown that CAVI is associated with atherosclerotic disease 23,[25][26][27][28] , which is also considered to be a useful method to detect coronary artery calcification 29) . This study compares CAC score with CAVI in the prediction of cardiovascular events in asymptomatic patients with type 2 diabetes.…”

Cardiac-Ankle Vessel Index and Short Term Results of Coronary Bypass Grafting in Coronary Heart Disease

“…Действительно, при изучении СЛСИ у больных ИБС достаточно убедительно показана его связь с рас-пространенностью коронарного атеросклероза [3,10,11]. Так, у больных сахарным диабетом 2-го типа СЛСИ позитивно коррелировал с кальциевым индек-сом коронарных артерий, определяемым при мульти-спиральной компьютерной томографии (r=0,303, p<0,0001) [10].…”

“…Так, у больных сахарным диабетом 2-го типа СЛСИ позитивно коррелировал с кальциевым индек-сом коронарных артерий, определяемым при мульти-спиральной компьютерной томографии (r=0,303, p<0,0001) [10]. Также есть свидетельства о наличии связи между СЛСИ и распространенностью [11] и выраженностью коронарного атеросклероза [6,9,12,13].…”