Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Pizzol, Damiano; Demurtas, Jacopo; Stubbs, Brendon; Soysal, Pınar; Mason, Corina; Işık, Ahmet Turan; Solmi, Marco; Smıth, Lee; Veronese, Nicola

doi:10.1177/1557988319892464

Cited by 43 publications

(18 citation statements)

References 40 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent meta-analysis including 3395 men demonstrated a higher prevalence of ED in cannabis users (up to four times) compared to controls. 26 However, the overall low quality of the published studies on this topic may preclude the consideration of cannabis use being a strong risk factor for ED in the general population. 27 Our results showed that among current SoA users, 77.3% of them were cannabis consumers.…”

Section: Discussionmentioning

confidence: 99%

Substances of abuse consumption among patients seeking medical help for uro-andrological purposes

Salonia

Belladelli

Boeri

et al. 2021

Asian Journal of Andrology

View full text Add to dashboard Cite

originally used as an anesthetic agent in the 1880s, but since the 1970s, it has been considered a recreational drug. Cocaine users were found to have increased risk of impaired sperm concentration 13 and low testosterone levels 14 as compared to nonusers. Similarly, prolonged cocaine use has been consistently associated with low sexual desire and erection difficulties in middle-age men. 15 Opioids are commonly prescribed in pain management, but their recreational use and abuse is well known worldwide. As for their uro-andrological side effects, men reporting heroin addiction have a lower weekly sexual intercourse rate and show decreased masturbatory activity compared to nonusers. 16 Furthermore, previous reports have also highlighted the negative impact of opioid use in terms of semen parameters. 2,17 A recent Iranian study showed that opium-addicted men presented with a higher rate of lower sperm concentration, lower antioxidant activity, and a higher sperm DNA fragmentation index compared to nonopium users. 17 Furthermore, erectile dysfunction (ED) was also found to be highly prevalent among male patients treated with methadone maintenance therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Substances of abuse consumption among patients seeking medical help for uro-andrological purposes

Salonia

Belladelli

Boeri

et al. 2021

Asian Journal of Andrology

View full text Add to dashboard Cite

show abstract

“…A recent meta-analysis examining the relationship between cannabis use and erectile dysfunction found that cannabis users were almost four times as likely to suffer from erectile dysfunction compared to controls (odds ratio 3.83, p=0.02). 19 This meta-analysis included 5 studies involving over 3,300 subjects. In comparison the present study included over 7,000 subjects and found that rates of erectile dysfunction, as determined by a SHIM score ≤21, were increased in cannabis non-users.…”

Section: Cuaj -Original Researchmentioning

confidence: 99%

The impact of cannabis use on male sexual function: A 10-year, single-center experience

Shiff

Blankstein

Hussaen

et al. 2021

CUAJ

View full text Add to dashboard Cite

Introduction: Despite increasing consumption rates in much of the world, the impact of cannabis use on various components of male sexual function remain poorly established. The purpose of this study was to further evaluate the relationship between cannabis use and reproductive and sexual function using a large patient cohort from a single academic andrology clinic. Methods: This is a historical cohort study from a single academic center andrology clinic. Patients from 2008–2017 were included. Intake questionnaires provided baseline demographic information, as well as data regarding substance use and various sexual function parameters. Subjects were categorized as cannabis users or non-users. Cannabis users and non-users were compared using descriptive statistics and Chi-squared tests, and regression analyses were performed to test for association. Results: A total of 7809 males were included in the study; 993 (12.7%) were cannabis users and 6816 (87.3%) were non-users. Cannabis users had a higher mean Sexual Health Inventory for Men (SHIM) score (21.94.4 vs. 21.24.8, p<0.001) and mean serum total testosterone (13.412.0 nmol/L vs. 12.611.8 nmol/L, p=0.04) than non-users, although they also had a higher rate of positive Androgen Deficiency in the Aging Male (ADAM) scores (52% vs. 46%, p<0.001). Cannabis users also reported higher sexual frequency compared to non-users (8.8 events/month vs. 7.8 events/month, p<0.05). On multivariate analysis, cannabis use was not associated with SHIM score or serum testosterone concentration. Cannabis use was associated with positive ADAM scores. Conclusions: Cannabis use was not associated with clinically significant deleterious effects on male sexual parameters in this cohort.

show abstract

“…It could be speculated that low levels of sexual activity during the pandemic may be partly caused by an increase in population levels of sexual dysfunction. Erectile dysfunction (ED) is the most common sexual health issue in men, and it can be caused by organic, hormonal, and/or psychological factors [6]. In turn, ED is associated with a substantial range of mental, physical and psychologically adverse outcomes, including anxiety, low mood and quality of life [6].…”

Section: Introductionmentioning

confidence: 99%

Social environmental impact of COVID-19 and erectile dysfunction: an explorative review

Pizzol¹,

Shin

Trott

et al. 2021

J Endocrinol Invest

Self Cite

View full text Add to dashboard Cite

Background To date, no attempt has been made to collate literature on the relationship between the social environmental impact of COVID-19 and erectile dysfunction. The aim of this explorative review was to assess and compare the prevalence of erectile dysfunction (ED) in male healthcare workers and males during the COVID-19 pandemic. Methods A systematic review of major databases from inception to February 2021 was conducted. Prevalence data were extracted, and a random-effects meta-analysis was undertaken. Outcomes The pooled prevalence of ED amongst healthcare workers working in COVID-19 specific environments, and non-healthcare during the COVID-19 pandemic. Results Of 52 initial studies, six were included for the final analysis. The pooled prevalence of ED in healthcare workers working in a COVID-19 environment was 63.6% (95% CI 20.3-92.3%), and in non-healthcare workers during the COVID-19 pandemic was 31.9% (95% CI 19.5-47.6%). ConclusionThe prevalence of ED in healthcare workers working in COVID-19 environments was higher than representative samples and is of concern. Sexual health (and by extension, overall health), should be a priority when considering ways to care for this population. Considering the social environmental impact of COVID-19 on sexual health and in particular on ED, it is important to provide adequate psychological support systems and to promote quality of life with particular attention to sexual health.

show abstract

Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

Cited by 43 publications

References 40 publications

Substances of abuse consumption among patients seeking medical help for uro-andrological purposes

Substances of abuse consumption among patients seeking medical help for uro-andrological purposes

The impact of cannabis use on male sexual function: A 10-year, single-center experience

Social environmental impact of COVID-19 and erectile dysfunction: an explorative review

Contact Info

Product

Resources

About