Relationship between cannabinoids content and composition of fatty acids in hempseed oils

Petrović, Marinko; Debeljak, Željko; Kezić, Nataša; Džidara, Petra

doi:10.1016/j.foodchem.2014.08.039

Cited by 71 publications

(48 citation statements)

References 19 publications

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“…Regarding hemp products, a wide range of solvents that is compatible with cannabinoids, which includes methanol, acetonitrile, isopropanol, and hexane, even with different mixing ratios. [23][24][25] However, our study has shown that the better extraction yield of cannabinoids appears in solvent 60% isopropanol and 100% methanol, which might explain the similar polarities between the solvents and the analytes. Figure 2 shows the HPLC-MS/MS chromatogram of the proposed HPLC-MS/MS method, which was applied to determine the cannabinoids in the hemp nut samples.…”

Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

“…Pellegrini et al [24] reported 6 hemp food products from Italy including beer, pastilles, liqueur, seeds, scented grass, and oil with a THC content ranging from 0.01 to 0.35 μg/g, a CBD content ranging from 0.01 to 0.09 μg/g, and a CBN content ranging from 0.01 to 0.16 μg/g. Petrovic et al [25] reported 11 hemp seed oils from Croatia with a THC content ranging from 3.0 to 69.5 μg/g, a CBD content ranging from 4.2 to 235.7 μg/g, and a CBN content ranging from 1.9 to 8.4 μg/g.…”

Section: Quantitative Determination Of Hemp Nut Productsmentioning

confidence: 99%

“…It allows rapid classifications at an early stage of growth without determining the chemotype after maturity; moreover, the false positive rates of the method were less than 2%. Petrović et al [25] revealed the relationship of cannabinoids content and composition of fatty acids in hemp seed oils by using PCA. A negative correlation has been found between (THC + CBN)/CBD ratios and the levels of γ-linolenic and stearidonic acid, i.e., the industrial hemp may elicit a greater benefit because of the higher levels of those fatty acids.…”

Section: Cbd-to-thc Ratio Of Hemp Nut Productsmentioning

confidence: 99%

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Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Chang

Tung

Tsai

et al. 2016

Drug Testing and Analysis

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Hemp nuts are mature cannabis seeds obtained after shelling and that are commonly used in traditional Chinese medicine for treating functional constipation. In this work, we screened hemp nut products, classified them, and verified the legality of consuming them. A total of 18 products were purchased from Taiwan, China, and Canada. Validated high-performance liquid chromatography with tandem mass spectrometry methods were developed for analyzing the cannabinoid (i.e., Δ -tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol) content of the products and the concentration of urinary 11-nor-9-carboxy-THC. Chemometric techniques, namely hierarchical clustering analysis (HCA) and principal component analysis (PCA), were applied for rapidly classifying 11 concentrated powder products in Taiwan. A pilot human study comprising single and multiple administrations of a product with 1.5 µg/g of THC was conducted to examine the urinary 11-nor-9-carboxy-THC concentration. Through optimization of 3 full factorial design, using 60% isopropanol as the extraction solvent exhibited the highest yield of cannabinoids and was applied as the optimal condition in further analysis. The results of HCA and PCA on quality evaluation were in good agreement; however, the tested products possessed distinct CBD-to-THC ratios which ranged widely from 0.1:1 to 46.8:1. Particularly, the products with CBD-to-THC ratios higher than 1:1 were the majority in Taiwan. Our data suggested that all the tested hemp nut products met the Taiwan restriction criterion of 10 µg/g of THC. We propose a usual consumption amount of hemp nut products in Taiwan would unlikely to violate the cut-off point of 15 ng/mL of urinary 11-nor-9-carboxy-THC. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 99%

Section: Quantitative Determination Of Hemp Nut Productsmentioning

confidence: 99%

Section: Cbd-to-thc Ratio Of Hemp Nut Productsmentioning

confidence: 99%

See 2 more Smart Citations

Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Chang

Tung

Tsai

et al. 2016

Drug Testing and Analysis

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“…Previous studies showed that about 800 mg/kg tocopherol can be found in the pressed hempseed oil which is a significant amount (Oomah, Busson, Godfrey, & Drover, 2002). Other bioactive components were found in hempseed oil such as β-carotene, polyphenols, and chlorophylls (Liang, Appukuttan Aachary, & Thiyam-Holländer, 2015;Petrović, Debeljak, Kezić, & Džidara, 2015;Teh & Birch, 2013).…”

Section: Introductionmentioning

confidence: 99%

Investigation on the extraction yield, quality, and thermal properties of hempseed oil during ultrasound‐assisted extraction: A comparative study

Rezvankhah

Emam‐Djomeh

Safari

et al. 2018

J Food Process Preserv

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The efficiency of ultrasound‐assisted extraction (UAE) was evaluated for hempseed oil extraction using response surface methodology (RSM), and the obtained optimum point was 91 W and 10 min. In which, the extraction yield was obtained 33.61% w/w which was lower than Soxhlet extraction (37.93% w/w), whereas the process time was shorter than Soxhlet method (10 min vs. 8 hr). Extracted oil by UAE showed better oxidation stability and stronger antioxidant activity. TOTOX values were 2.95 and 16.49 and IC50 values were calculated as 29.54 and 32.47 mg/ml, for UAE and SE, respectively. Tocopherol, fatty acid composition, and thermal behavior of oils were analyzed by HPLC, GC, and DSC, respectively. Results showed that UAE can effectively extract oil‐soluble components such as tocopherols with less deterioration effect. Fatty acid profiles did not show a remarkable difference but DSC indicated that partial difference in fatty acid composition and possibly triglycerides occurred in different thermal attributes. Practical applications Plant seed oils such as hempseed oil due to having a high amount of polyunsaturated fatty acids (PUFAs) can be applied in many application fields considering food enrichments and capsules including PUFAs which are too necessary for human bodies. So, oil extraction of such these sources is so highlighted and critical due to being sensitive to oxidation conditions. Novel extraction procedures are so promising caused by their shortened process time and presenting high‐quality products with high extraction efficiency comparable with Soxhlet extraction. UAE is a method based on bubble cavitation which improves oil extraction. It reduces extraction time by considering the high quality of extracted oil due to its high antioxidant activity capacity. In a recent study, ultrasound‐extracted oil compared with Soxhlet which exhibited that the process time was significantly reduced with presenting better oil oxidative stability and acceptable antioxidant activity resulted from high tocopherol extraction and the eventually better remaining of bioactive components due to lower deterioration effects of UAE. Additionally, the determined fatty acid compositions did not show the highlighted difference. The results by differential scanning calorimetry indicated that not only fatty acid compositions can alter the thermograph peaks but also crystal structures possibly affected the associated attributes.

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Comparative Biological Activities Determination of Aqueous Extracts of Hempseed Oil and Hempseed Protein Isolate Production Coproducts

Dia

Wang

Yang

et al. 2019

J Americ Oil Chem Soc

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Relationship between cannabinoids content and composition of fatty acids in hempseed oils

Cited by 71 publications

References 19 publications

Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Determination of cannabinoids in hemp nut products in Taiwan by HPLC‐MS/MS coupled with chemometric analysis: quality evaluation and a pilot human study

Investigation on the extraction yield, quality, and thermal properties of hempseed oil during ultrasound‐assisted extraction: A comparative study

Comparative Biological Activities Determination of Aqueous Extracts of Hempseed Oil and Hempseed Protein Isolate Production Coproducts

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