Relationship between cancer stem cell-related SNPs and survival outcomes in patients with primary lung cancer

Abstract

Background Cancer stem cells may be the source of cancer-causing mutant cells and are closely related to the prognosis of cancer. Our study aimed to investigate the potential association between single-nucleotide polymorphisms (SNPs) of cancer stem cell-related genes and the prognosis of lung cancer patients. Methods The SNP loci were genotyped by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF–MS), and the overall survival of subjects was analyzed by log-rank test after stratifying and adjusting their demographic data, clinical data, and genotypes. The correlation between survival time and quality of life of lung cancer under codominant, dominant, recessive, and additive genetic models was analyzed by the Cox regression model. The association between SNP polymorphism and the prognosis of lung cancer was analyzed by Stata16.0 software, and their heterogeneity was tested. Interaction analysis was performed using R software (version 4.2.0). Results Stratified analysis unveiled that rs3740535 had recessive AA genotype and additive GG genotype; Rs3130932 dominant GT + GG genotype, additive TT genotype; Rs13409 additive TT genotype; Rs6815391 recessive CC genotype and additional TT genotype were associated with increased risk of lung cancer death. Rs3130932 recessive GG genotype was associated with a reduced risk of lung cancer death. Conclusion Rs3740535, rs3130932, rs13409, and rs6815391 are associated with the overall survival of lung cancer patients and may be valuable for the prognosis of lung cancer patients.

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

“…Cancer stem cells (CSCs) are a population of cells with the ability to differentiation, proliferation, and self-refinement, which play an important role in tumor progression ( Chiba et al, 2007 ), inflammation ( Zhao et al, 2023 ), drug resistance ( Choi et al, 2020 ), and prognosis ( Xu et al, 2023 ). Abnormal mechanistic signals in TME can affect the proliferation, differentiation, stemness, and other biological behaviors of CSCs ( Shen et al, 2021 ; Nguyen Ho-Bouldoires et al, 2022 ).…”