Relationship Between Cancer of Stomach and the ABO Blood Groups

Abstract

It was shown by Stocks (1950) Legon (1951Legon ( , 1952 in attempts to correlate the geographical variations in the mortality from gastric cancer with variations in the organic content of the soil.It occurred to one of us that there might be a correlation between the high northern incidence of cancer of the stomach and the genetic differences which are reflected in the ABO blood groups, the frequency of blood group 0 being greater, that of A less, in northern than in southern populations, B and AB being similar in all geographical areas in England and Scotland.Previous published work on the association of the ABO blood groups with cancer has been on very small series of cases without adequate controls. The results have been diverse and without statistical significance (Alexander, 1921 ; Johannsen, 1925;Goldfeder and Fershing, 1937). MethodA collection was made of cases of cancer of the stomach from a number of hospitals in England and Scotland, and the distribution of the ABO blood groups in patients with stomach cancer from each hospital was compared with the distribution of ABO blood groups in an equal number of patients chosen at random from the same hospital. The criterion of diagnosis has in most cases been a histological

ABO and Rh Blood Groups and Risk of Colorectal Adenocarcinoma

“…Possible associations between ABO blood group and the risk of some epithelial malignancies, including pancreatic cancer and gastric cancer have been reported previously (Aird et al, 1953;Amundadottir et al, 2009;Wolpin et al, 2009;Greer et al, 2010;Iodice et al, 2010). Aird et al (1953) reported a relationship between gastric cancer and ABO blood groups in the 1950s.…”

“…Aird et al (1953) reported a relationship between gastric cancer and ABO blood groups in the 1950s. The frequency of blood group A was greater and O was lower in patient with gastric cancer than normal population.…”

“…ABO blood group genes are mapped at the chromosome 9, in which the genetic alteration is common in many cancers (Hosoi, 2008). The correlations of ABO blood groups and Rh either with benign or malignant diseases have been observed for a long time In 1953 Aird et al reported such a relationship with stomach cancer (Aird et al, 1953). Recently a significant association between ABO blood groups and cancer of the pancreas was reported (Wolpin et al, 2009;Greer et al, 2010;Iodice et al, 2010).…”

Relationships between Skin Cancers and Blood Groups - Link between Non-melanomas and ABO/Rh Factors

“…Therefore, it has been reported that genetic changes on the chromosome 9 may have an effect on the release of ABO blood group antigens. Several studies have shown that changes in the ABO/Lewis blood group antigens may be associated with the malignant transformation for some tumors (Aird et al, 1953;Jordan and Lynch, 1983;Rolfe et al, 2002;Adamian, 2005;Tursen et al, 2005;El Hajj et al, 2007;Hosoi, 2008;Edgren et al, 2010;Iodice et al, 2010).…”

“…In 1953, Aird et al (1953) first reported such a relationship between A blood group and gastric cancer. Subsequent studies confirmed that the incidence of gastric cancer was higher (nearly 20%) in individuals with A blood group.…”