Relationship Between Breast Milk Feeding and Atopic Dermatitis in Children

Nakamura, Yosikazu; Oki, Izumi; Tanihara, Shinichi; Ojima, Toshiyuki; Ito, Yoshinobu; Iwama, Masato; Tabata, Yoshiki; Katsuyama, Kazuaki; Sasai, Yasunori; Nakagawa, Masashi; Matsushita, Akihiro; Hosaka, Koji; Sato, Junko; Hidaka, Yoshio; Uda, Hidenori; Nakamata, Kazuyuki; Yanagawa, Hiroshi

doi:10.2188/jea.10.74

Cited by 7 publications

(5 citation statements)

References 11 publications

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“…The 42 records for eczema comprised 24 records from cohort studies , 17 from cross‐sectional studies and one case–control . There were 26 studies from high‐income countries and 14 from middle‐/low‐income countries.…”

Section: Resultsmentioning

confidence: 99%

Breastfeeding and asthma and allergies: a systematic review and meta‐analysis

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Breastfeeding and asthma and allergies: a systematic review and meta‐analysis

et al. 2015

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“…Of these, 109 publications reached an NOS score indicating high quality, whereas the rest obtained an NOS score of at least 5. 24,31,34,35,39,40,44,[66][67][68][69][70][71][72][73]144,152 Quantitative analysis A meta-analysis of 66 studies (38,505 patients with AD and 203,146 reference individuals) showed that those with a parental history of atopic disease had significantly increased odds of AD (OR, 1.81; 95% CI, 1.65-1.99) (Table I). No significant changes were observed when only high-quality studies were included, or when studies were stratified by geographic area or study size (Table II).…”

Section: Resultsmentioning

confidence: 99%

“…43,184 Limited data examined how other atopic-related diseases such as urticaria, conjunctivitis, and food allergy in parents influenced the risk of AD in offspring. 41,55,70,99 Three birth cohorts investigated the association between maternal symptoms of atopic disease during pregnancy and AD in offspring. A German study found a positive association with symptoms of any atopic disease (adjusted OR, 1.74; 95% CI, 1.00-3.02; P 5 .045), 150 a Canadian study with symptoms of asthma, 171 while an American study found this only for symptoms of AD (RR, 1.70; 95% CI, 1.10-2.60; P 5 .033) and asthma (RR, 1.80; 95% CI, 1.20-2.70; P 5 .015), but not allergic rhinitis (RR, 1.27; 95% CI, 0.91-1.80; P 5 .155).…”

Section: Qualitative Analysismentioning

confidence: 99%

How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis

Ravn

Halling

Berkowitz

et al. 2020

Journal of Allergy and Clinical Immunology

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Background: Parental history of atopic disease is a wellestablished risk factor for the development of atopic dermatitis (AD), but several aspects of this association remain unclear. Objective: We sought to determine the association of parental history of atopic disease with AD in offspring. Methods: We searched PubMed and EMBASE through June 2018 for relevant records and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pooled odds ratios (ORs) with 95% CI were calculated using random-effects models. Results: A total of 163 records covering 149 unique studies were included. Of these, 119 studies were included in the metaanalysis. Individuals with parental history of atopic disease had increased odds of AD (OR, 1.81; 95% CI, 1.65-1.99). Parental asthma (OR, 1.56; 95% CI, 1.18-2.05) and allergic rhinitis (OR, 1.68; 95% CI, 1.34-2.11) had a smaller effect than AD (OR, 3.30; 95% CI, 2.46-4.42). The effect of maternal and paternal history was comparable for all atopic diseases. An increase in odds was observed when comparing the effect of having 1 (OR, 1.30; 95% CI, 1.15-1.47) or 2 atopic parents (OR, 2.08; 95% CI, 1.83-2.36), as well as having a parent with 1 (OR, 1.49; 95% CI, 1.28-1.74) or more atopic diseases (OR, 2.32; 95% CI, 1.92-2.81). Conclusions: This study provides evidence-based risk estimates that may guide physicians who counsel parents with a history of atopic disease about their children's risk of AD. This information is of particular importance for future efforts toward establishing prophylactic interventions for AD on a general population level.

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“…The exclusion of non‐English literature may result in language bias. Of the 10 non‐English publications excluded, four were original studies, 59–62 and all suggested no protective effects of breastfeeding on AD. If these four articles were included into the meta‐analysis, the overall effect estimate would be further attenuated toward the null, which would not alter our conclusions.…”

Section: Discussionmentioning

confidence: 99%