Relationship between brachycephalic airway syndrome and gastrointestinal signs in three breeds of dog

Kaye, B. M.; Rutherford, Lynda; Perridge, D. J.; Haar, Gert ter

doi:10.1111/jsap.12914

Cited by 32 publications

(65 citation statements)

References 21 publications

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“…We did not intend to investigate the management of brachycephalic dogs with BOAS in this study, but dogs of such breeds were significantly more likely to receive omeprazole and maropitant in the Surgery ward for the stated reasons of decreasing the rate and/or consequences of regurgitation and GOR under anaesthesia. Both problems are common in brachycephalic dogs 34,35 , though the prevalence of intra-operative GOR did not differ between brachycephalic and control dogs in a previous study 36 . Regurgitation in brachycephalic dogs is attributed principally to excessive negative pressure in the thorax 37 , but it is unclear whether affected dogs also experience nausea.…”

Section: Discussionmentioning

confidence: 62%

“…Regurgitation in brachycephalic dogs is attributed principally to excessive negative pressure in the thorax 37 , but it is unclear whether affected dogs also experience nausea. Interestingly, owners reported ptyalism, which is often taken as a sign of nausea, to be much less common in such dogs than regurgitation 34 . Additionally, in our experience, brachycephalic dogs with regurgitation rarely have a decreased appetite, which might be expected if they were experiencing nausea.…”

Section: Discussionmentioning

confidence: 99%

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Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

McCormack

Olley

Glanemann

et al. 2020

Sci Rep

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The proton pump inhibitor omeprazole is administered to dogs with gastroduodenal ulceration or oesophagitis, whereas the neurokinin-1 receptor antagonist maropitant citrate is licensed as an antiemetic drug. In people, omeprazole is overprescribed in hospitals, increasing the risk of adverse effects and imposing unnecessary costs in healthcare. To investigate the use of omeprazole and maropitant in our veterinary specialist hospital, we conducted a prospective observational study in its Medicine and Surgery wards, recording patient data and obtaining contemporaneous information from clinicians about their reasons for administering either drug. In doing so, we find omeprazole and maropitant are administered to a large proportion of dogs, including to many of those with no presenting signs suggestive of gastrointestinal disease. We find prescribing clinicians consider both drugs safe but often underestimate their financial cost. We find the stated reasons and objective predictors of administration of both drugs vary according to clinical setting but that these modalities yield concordant results. Reviewing the manner of administration and stated indications for use of both drugs, we find omeprazole is often administered outside dosing recommendations, and both drugs are frequently administered for aims that are unlikely to be achieved when considering their known biological effects in dogs. In conclusion, our work reveals probable overprescribing of omeprazole and maropitant citrate in hospitalised dogs, highlighting a need for initiatives to decrease inappropriate prescribing.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

McCormack

Olley

Glanemann

et al. 2020

Sci Rep

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“…Consistent with available data, snoring, inspiratory efforts, and exercise intolerance were the most common presenting clinical signs, followed by syncope . Moreover, 76.7% of dogs with respiratory problems also had gastrointestinal clinical signs, specially vomiting and regurgitation . Although it is not frequently described, SDB may be consequence of BAOS .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of metabolic profile and C‐reactive protein concentrations in brachycephalic dogs with upper airway obstructive syndrome

Gianella

Caccamo

Bellino

et al. 2019

Veterinary Internal Medicne

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Background Brachycephalic dogs have abnormal breathing patterns similar to those in humans with obstructive sleep apnea syndrome. Obstructive sleep apnea syndrome is associated with dyslipidemia, hyperglycemia, and insulin resistance. Despite the fact that anatomic and functional alterations are well described in brachycephalic dogs, little is known about the consequences of upper airway obstruction on systemic inflammatory response and metabolic profile. Objectives To describe history, clinical presentation, and anatomic abnormalities; to evaluate systemic inflammatory response and metabolic profile; and to identify possible associations among clinical signs, anatomic abnormalities, inflammatory response, and metabolic profile in brachycephalic dogs with airway obstruction. Animals Thirty purebred brachycephalic dogs with brachycephalic airway obstructive syndrome (BAOS). Methods Prospective study. The following information was recorded and studied: respiratory and digestive signs, airway and digestive endoscopic anomalies, presence or absence of tracheal hypoplasia, histologic evaluation of gastrointestinal tract biopsy specimens, serum concentrations of C‐reactive protein (CRP), fructosamine, insulin, glucose, triglyceride, cholesterol, and plasma concentrations of lipoprotein classes. Results A high proportion of dogs (76.7%) had gastrointestinal signs. Esophageal deviation, atony of the cardia of the stomach, and distal esophagitis were the most common endoscopic anomalies detected. Twenty‐six (86.6%) dogs had different degrees of laryngeal collapse. Gastrointestinal histologic evaluation identified mostly chronic inflammation. Glucose, fructosamine, triglycerides, cholesterol, CRP, pre‐beta, beta lipoproteins, and chylomicrons were increased to a variable extent. Significant associations among clinical signs, anatomic abnormalities, CRP, and metabolic profile were not found. Conclusion and Clinical Importance Despite the presence of inflammation and some mild metabolic derangements, the clinicopathological variables evaluated did not offer valuable information in dogs with BAOS.

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“…The formation of granulation tissue with inflammatory infiltrate on histopathology has been suggested to occur in brachycephalic dogs as a sequelae to repetitive micro-trauma secondary to airway collapse and negative upper airway pressures in a study of French bulldogs (Sarran et al 2018). French bulldogs have a high prevalence of regurgitation and vomiting (Kaye et al 2018) and it was suggested that gastro-oesophageal reflux could be a contributing factor as in humans, although this has not specifically investigated in dogs. In contrast, only one French bulldog with an inflammatory lesion (granulation tissue with neutrophilic inflammation) was identified in this study.…”

Section: Discussionmentioning

confidence: 99%

Infiltrative laryngeal disease in dogs

Dixon

Tivers²,

Packham

et al. 2020

J of Small Animal Practice

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Objectives To describe the clinical features and outcome of neoplastic and inflammatory infiltrative laryngeal disease in dogs. Materials and Methods Medical records at a single referral centre were retrospectively reviewed for dogs diagnosed with infiltrative laryngeal disease by CT or laryngoscopy. Results Fifteen dogs were included, with a median age of 6 years (range 1‐14 years). Thirteen dogs were diagnosed with inflammatory disease including granulation tissue (n = 4) and neutrophilic (n = 2), septic neutrophilic (n = 2), eosinophilic (n = 1) lymphocytic/plasmacytic (n = 1) and mixed/unclassified (n = 3) inflammation. One dog was diagnosed with large cell lymphoma and one dog was diagnosed with mast cell tumour. Twelve dogs survived to discharge. Follow‐up was available for 10 dogs diagnosed with inflammatory disease. Four had fully recovered (7, 10, 23 and 32 months) and one dog developed acute leukaemia and was euthanased at 2 months. Five dogs had recurrence of clinical signs at 1, 1, 5, 17 and 26 months. The dog with lymphoma was euthanased at 8 months and the dog with mast cell tumour died at 5 months. Clinical Significance In this cohort, infiltrative inflammatory lesions of the larynx were more common than neoplastic infiltration. For dogs that survived to discharge, outcome was fair although relapse was common.

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Relationship between brachycephalic airway syndrome and gastrointestinal signs in three breeds of dog

Abstract: The prevalence of gastrointestinal signs in dogs presenting with brachycephalic airway syndrome and improvement in these clinical signs following corrective surgery may vary between breeds.

Cited by 32 publications

References 21 publications

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

Evaluation of metabolic profile and C‐reactive protein concentrations in brachycephalic dogs with upper airway obstructive syndrome

Infiltrative laryngeal disease in dogs

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